机构

• 上海药物研究所 [4]
• 新疆理化技术研究所 [1]
• 大连化学物理研究所 [1]
• 海洋研究所 [1]

采集方式

• OAI收割 [7]

内容类型

• 期刊论文 [7]

发表日期

• 2021 [1]
• 2018 [1]
• 2015 [1]
• 2013 [2]
• 2012 [1]
• 2003 [1]
• 更多

学科主题

• Chemistry [1]
• Pharmacolo... [1]

筛选

浏览/检索结果: 共7条，第1-7条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20 作者:  Zhang, Rui;  Li, Heng;  Zhang, Xianglei;  Li, Jian;  Su, Haixia   |  收藏  |  浏览/下载：48/0  |  提交时间：2021/05/24 PDE4 inhibitors  Tetrahydroisoquinoline  Antipsoriasis   Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5) 期刊论文  OAI收割 ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636 作者:  Ni, Wei;  Wang, Huan;  Li, Xiaokang;  Zheng, Xinyu;  Wang, Manjiong   |  收藏  |  浏览/下载：62/0  |  提交时间：2019/01/08 Multifunctional agents  AChE inhibitors  PDE5 inhibitors  Alzheimer's disease   preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel 期刊论文  OAI收割 actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1528 作者:  Gao Zhiwei;  Zhu Yunting;  Yu Mingming;  Zan Bin;  Liu Jia   |  收藏  |  浏览/下载：21/0  |  提交时间：2020/07/01 HUMAN DRUG CLEARANCE  PHOSPHODIESTERASE-5 INHIBITORS  CLINICAL PHARMACOKINETICS  ERECTILE DYSFUNCTION  TISSUE DISTRIBUTION  ORAL PHARMACOKINETICS  RECEPTOR ANTAGONIST  DIVERSE COMPOUNDS  IN-VIVO  ABSORPTION  TPN729MA  PDE5 inhibitor  erectile dysfunction  pharmacokinetics  human PK prediction  physiologically based pharmacokinetic model   Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947 作者:  Gong, Xudong;  Wang, Guan;  Ren, Jing;  Liu, Zheng;  Wang, Zhen   |  收藏  |  浏览/下载：21/0  |  提交时间：2019/01/08 PDE5 inhibitors  5-Bromopyrimidin-4(3H)-ones   Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947 作者:  Gong Xudong;  Wang Guan;  Ren Jing;  Liu Zheng;  Wang Zhen 收藏  |  浏览/下载：50/0  |  提交时间：2013/11/07 PDE5 inhibitors  5-Bromopyrimidin-4(3H)-ones   Exploring the structure determinants of pyrazinone derivatives as PDE5 3HC8 inhibitors: An in silico analysis 期刊论文  OAI收割 journal of molecular graphics & modelling, 2012, 卷号: 38, 页码: 112-122 作者:  Li, Yan;  Wu, Wenzhao;  Ren, Hong;  Wang, Jinghui;  Zhang, Shuwei 收藏  |  浏览/下载：31/0  |  提交时间：2015/11/13 PDE5  Pyrazinone-based inhibitors  3D-QSAR  Molecular docking  Molecular dynamics   Evidence for the involvement of cyclic AMP in the metamorphosis of bay scallop, Argopecten irradians (Lamarck) larvae 期刊论文  OAI收割 JOURNAL OF SHELLFISH RESEARCH, 2003, 卷号: 22, 期号: 2, 页码: 403-408 作者:  Zhang, T;  Yang, HS;  Que, HY;  Zhang, GF;  Liu, SL 收藏  |  浏览/下载：22/0  |  提交时间：2015/07/20 cAMP  metamorphosis  Argopecten irradians  catecholamines  L-DOPA  PDE inhibitors