机构

• 上海药物研究所 [10]
• 西双版纳热带植物园 [1]
• 中国科学院大学 [1]

采集方式

• OAI收割 [11]
• iSwitch采集 [1]

内容类型

• 期刊论文 [12]

发表日期

• 2023 [2]
• 2022 [1]
• 2021 [1]
• 2019 [2]
• 2018 [3]
• 2013 [1]
• 更多

学科主题

• Chemistry [1]
• Pharmacolo... [1]
• Plant Scie... [1]

筛选

浏览/检索结果: 共12条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：18/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 18, 页码: 11 作者:  Xu, Haiyu;  Li, Shufen;  Liu, Jiayuan;  Cheng, Jinlong;  Kang, Liping   |  收藏  |  浏览/下载：19/0  |  提交时间：2023/10/17 COVID-19  traditional Chinese medicine  TCMT-NDRD  antivirus  anti-inflammation   Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 1, 页码: 228-245 作者:  Li, Heng;  Zhang, Yao;  Liu, Moting;  Fan, Chen;  Feng, Chunlan   |  收藏  |  浏览/下载：19/0  |  提交时间：2022/06/15 Ulcerative colitis  Mucosal homeostasis  Gut microbiota  Epithelial barrier  PDE4   Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20 作者:  Zhang, Rui;  Li, Heng;  Zhang, Xianglei;  Li, Jian;  Su, Haixia   |  收藏  |  浏览/下载：31/0  |  提交时间：2021/05/24 PDE4 inhibitors  Tetrahydroisoquinoline  Antipsoriasis   Inhibition of phosphodiesterase-4 attenuates murine ulcerative colitis through interference with mucosal immunity 期刊论文  OAI收割 BRITISH JOURNAL OF PHARMACOLOGY, 2019, 卷号: 176, 期号: 13, 页码: 2209-2226 作者:  Li, Heng;  Fan, Chen;  Feng, Chunlan;  Wu, Yanwei;  Lu, Huimin   |  收藏  |  浏览/下载：32/0  |  提交时间：2020/07/01 Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 11, 页码: 5579-5593 作者:  Zhang, Xianglei;  Dong, Guangyu;  Li, Heng;  Chen, Wuyan;  Li, Jian   |  收藏  |  浏览/下载：24/0  |  提交时间：2020/07/01 Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases 期刊论文  OAI收割 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Li, Heng;  Zuo, Jianping;  Tang, Wei   |  收藏  |  浏览/下载：55/0  |  提交时间：2019/01/08 phosphodiesterase-4  psoriasis  atopic dermatitis  inflammatory airway diseases  inflammatory bowel  disease  roflumilast  apremilast  crisaborole   Linderane Suppresses Hepatic Gluconeogenesis by Inhibiting the cAMP/PKA/CREB Pathway Through Indirect Activation of PDE 3 via ERK/STAT3 期刊论文  OAI收割 FRONTIERS IN PHARMACOLOGY, 2018, 卷号: 9 作者:  Xie, Wei;  Ye, Yangliang;  Feng, Ying;  Xu, Tifei;  Huang, Suling   |  收藏  |  浏览/下载：41/0  |  提交时间：2019/01/08 cAMP  gluconeogenesis  linderane  phosphodiesterase  type 2 diabetes   A new selaginellin derivative and a new triarylbenzophenone analog from the whole plant of Selaginella pulvinata 期刊论文  OAI收割 JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2018, 卷号: 20, 期号: 12, 页码: 1123-1128 作者:  Liu, Xin;  Tang, Gui-Hua;  Weng, Han-Zhuang;  Zhang, Jun-Sheng;  Xu, You-Kai   |  收藏  |  浏览/下载：41/0  |  提交时间：2019/04/22 Phosphodiesterase-4 Inhibitors  Natural Pigment  Tamariscina   The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA 期刊论文  OAI收割 JOURNAL OF SEXUAL MEDICINE, 2013, 卷号: 10, 期号: 11, 页码: 2790-2797 作者:  Wang, Zhen;  Zhu, Difeng;  Yang, Xiaochun;  Li, Jianfeng;  Jiang, Xiangrui   |  收藏  |  浏览/下载：24/0  |  提交时间：2019/01/08 Erectile Dysfunction  Phosphodiesterase 5 Inhibitors  Pharmacology  Cyclic Guanosine Monophosphate  Selectivity and Potency