机构

• 上海药物研究所 [7]
• 大连化学物理研究所 [2]

采集方式

• OAI收割 [8]
• iSwitch采集 [1]

内容类型

• 期刊论文 [9]

发表日期

• 2023 [1]
• 2022 [1]
• 2021 [3]
• 2020 [2]
• 2019 [2]

学科主题

筛选

浏览/检索结果: 共9条，第1-9条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：32/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Targeting PDE4 as a promising therapeutic strategy in chronic ulcerative colitis through modulating mucosal homeostasis 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 1, 页码: 228-245 作者:  Li, Heng;  Zhang, Yao;  Liu, Moting;  Fan, Chen;  Feng, Chunlan   |  收藏  |  浏览/下载：35/0  |  提交时间：2022/06/15 Ulcerative colitis  Mucosal homeostasis  Gut microbiota  Epithelial barrier  PDE4   Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation 期刊论文  OAI收割 JOURNAL OF ADVANCED RESEARCH, 2021, 卷号: 33, 页码: 241-251 作者:  Li, Heng;  Zhang, Xianglei;  Xiang, Caigui;  Feng, Chunlan;  Fan, Chen   |  收藏  |  浏览/下载：121/0  |  提交时间：2021/11/04 PDE4  Arctigenin  Psoriasis  Inflammation   Inhibition of PDE4 by apremilast attenuates skin fibrosis through directly suppressing activation of M1 and T cells 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11 作者:  Lu, Qiu-kai;  Fan, Chen;  Xiang, Cai-gui;  Wu, Bing;  Lu, Hui-min   |  收藏  |  浏览/下载：68/0  |  提交时间：2021/06/11 PDE4  apremilast  skin fibrosis  macrophages   Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 20 作者:  Zhang, Rui;  Li, Heng;  Zhang, Xianglei;  Li, Jian;  Su, Haixia   |  收藏  |  浏览/下载：45/0  |  提交时间：2021/05/24 PDE4 inhibitors  Tetrahydroisoquinoline  Antipsoriasis   DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15 作者:  Li, Heng;  Li, Jian;  Zhang, Xianglei;  Feng, Chunlan;  Fan, Chen   |  收藏  |  浏览/下载：66/0  |  提交时间：2020/12/24 DC591017  PDE4  Inflammation  Macrophages  Dendritic cells  Psoriasis   DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15 作者:  Li, Heng;  Li, Jian;  Zhang, Xianglei;  Feng, Chunlan;  Fan, Chen   |  收藏  |  浏览/下载：36/0  |  提交时间：2020/12/24 DC591017  PDE4  Inflammation  Macrophages  Dendritic cells  Psoriasis   Rolipram, a PDE4 Inhibitor, Enhances the Inotropic Effect of Rat Heart by Activating SERCA2a 期刊论文  OAI收割 FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 12 作者:  Huang, Huili;  Xie, Ming;  Gao, Li;  Zhang, Wenhui;  Zhu, Xiaojia   |  收藏  |  浏览/下载：63/0  |  提交时间：2019/06/20 PDE4  rolipram  P-V loop  Ca2+ transient  SERCA2a   Rolipram, a pde4 inhibitor, enhances the inotropic effect of rat heart by activating serca2a 期刊论文  iSwitch采集 Frontiers in pharmacology, 2019, 卷号: 10, 页码: 12 作者:  Huang, Huili;  Xie, Ming;  Gao, Li;  Zhang, Wenhui;  Zhu, Xiaojia 收藏  |  浏览/下载：112/0  |  提交时间：2019/05/08 Pde4  Rolipram  P-v loop  Ca2+ transient  Serca2a