中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [27]
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(2R,6R)-hydroxynorketamine alleviates PTSD-like endophenotypes by regulating the PI3K/AKT signaling pathway in rats
期刊论文
OAI收割
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2024, 卷号: 245, 页码: 16
作者:
Liu, Lifen
;
Li, Rui
;
Wu, Lanxia
;
Guan, Yubo
;
Miao, Miao
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/11/18
Post-traumatic stress disorder
Negative emotions
PI3K/AKT signaling pathway
(2R
6R)-HNK
Berberine attenuates 5-fluorouracil-induced intestinal mucosal injury by modulating the gut microbiota without compromising its anti-tumor efficacy
期刊论文
OAI收割
HELIYON, 2024, 卷号: 10
作者:
Wu, Changhong
;
Yang, Jie
;
Ye, Chenxiao
;
Wu, Hui
;
Shu, Wenxi
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/11/22
5-Fluorouracil
Berberine
Intestinal mucositis
PI3K/AKT/mTOR pathway
Intestinal flora
Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathway
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13
作者:
Meng, Qian
;
Zhu, Hongwen
;
Li, Yuanyuan
;
Peng, Xiaotian
;
Wang, Tianming
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/05/07
Yinchenzhufu decoction
proteomics
cholestasis
liver fibrosis
PDGFR beta/PI3K/AKT
Inulin-like polysaccharide ABWW may impede CCl
4
induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway
in vitro
&
in vivo
期刊论文
OAI收割
CARBOHYDRATE POLYMERS, 2024, 卷号: 326, 页码: 15
作者:
Dai, Xiaolan
;
Du, Zhenyun
;
Jin, Can
;
Tang, Bixi
;
Chen, Xia
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2024/02/19
Fructan
Hepatic fibrosis
Hepatic stellate cells
FAK/PI3K/AKT
Acetaldehyde induces similar cytotoxic and genotoxic risks in BEAS-2B cells and HHSteCs: involvement of differential regulation of MAPK/ERK and PI3K/AKT pathways
期刊论文
OAI收割
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2023, 卷号: 30
作者:
Zhang, Jingni
;
Wang, Hongjuan
;
Chen, Huan
;
Liu, Yong
;
Wang, An
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/11/17
Acetaldehyde
Cytotoxicity
Genotoxicity
BEAS-2B cells
HHSteCs
MAPK/ERK
PI3K/AKT
Root-Extracted lignanamides from Limonium gmelinii (Willd.) Kuntze with a potential PTP1B inhibitory activity by regulating PI3K/AKT signaling pathway
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 132, 页码: 9
作者:
Tuohongerbieke, Amanguli
;
Liu, Liu
;
Li, Jun
;
Xin, Xuelei
;
Aisa, Haji Akber
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/10/17
Limonium gmelinii (Willd
) Kuntze
Plumbaginaceae
Lignanamides
Protein tyrosine phosphatase 1B inhibitors
PI3K
AKT Signaling Pathway
二苯乙烯类化合物对胰岛素抵抗HepG2细胞糖脂代谢紊乱的改善作用
期刊论文
OAI收割
中国药理学通报, 2023, 卷号: 39, 期号: 09, 页码: 1746-1754
作者:
马宏婷
;
铁芳芳
;
王瑞楠
;
胡娜
;
王洪伦
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/12/01
二苯乙烯类化合物
HepG2
胰岛素抵抗
糖脂代谢
PPARγ
PI3K/Akt/mTOR1
High throughput-screening of native herbal compounds identifies taccaoside A as a cytotoxic compound that mediates RAS signaling in cancer stem cells
期刊论文
OAI收割
PHYTOMEDICINE, 2023, 卷号: 108, 页码: 154492
作者:
Yang,Dong
;
Dai,Zhi
;
Zhu,Peifeng
;
Wang,Gan
;
Sun,Bin
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/07/17
Natural product
Furostanol saponin
Taccaoside A
Cancer stem cell
RAS
STEROIDAL SAPONINS
NATURAL-PRODUCTS
PI3K/AKT
PROLIFERATION
MAINTENANCE
STATISTICS
MAPK/ERK
Multi-omics analysis reveals the pathogenesis of db/db mice diabetic kidney disease and the treatment mechanisms of multi-bioactive compounds combination from Salvia miltiorrhiza
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 16
作者:
Xu, Zhuo
;
Xiang, Xiang
;
Su, Shulan
;
Zhu, Yue
;
Yan, Hui
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2022/12/13
multi-bioactive compounds combination
diabetic kidney disease
multi-omics
Salvia miltiorrhiza
PI3K/Akt/FoxO signaling pathways
Nrf2-mediated liver protection by 18 beta-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K/Akt/GSK3 beta pathway
期刊论文
OAI收割
PHYTOMEDICINE, 2022, 卷号: 102, 页码: 12
作者:
Wang, Zhangting
;
Ma, Jiang
;
He, Yisheng
;
Miu, Kai-Kei
;
Yao, Sheng
  |  
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2022/08/30
Pyrrolizidine alkaloids
Herb-induced liver injury
18 beta-glycyrrhetinic acid
Liquorice
Nuclear factor erythroid-2-related factor 2
PI3K/Akt/GSK3 beta