机构

• 上海药物研究所 [5]
• 合肥物质科学研究院 [2]
• 过程工程研究所 [1]
• 海洋研究所 [1]

采集方式

• OAI收割 [9]

内容类型

• 期刊论文 [9]

发表日期

• 2024 [3]
• 2022 [2]
• 2021 [1]
• 2020 [2]
• 2018 [1]

学科主题

筛选

浏览/检索结果: 共9条，第1-9条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery and optimization of 3-(indolin-5-yloxy)pyridin-2-amine derivatives as potent necroptosis inhibitors 期刊论文  OAI收割 ARCHIV DER PHARMAZIE, 2024, 页码: 21 作者:  Lan, Yaohan;  Ji, Yinchun;  Peng, Xia;  Duan, Wenhu;  Geng, Meiyu   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/08/22 autoimmune disease  necroptosis inhibitor  pharmacokinetic profile  receptor interacting protein kinase 1 (RIPK1)  structural optimization   Paralichthys olivaceus MLKL-mediated necroptosis is activated by RIPK1/3 and involved in anti-microbial immunity 期刊论文  OAI收割 FRONTIERS IN IMMUNOLOGY, 2024, 卷号: 15, 页码: 11 作者:  Hao, Kangwei;  Xu, Hang;  Jiang, Shuai;  Sun, Li   |  收藏  |  浏览/下载：34/0  |  提交时间：2024/04/07 Paralichthys olivaceus  necroptosis  RIPK1  RIPK3  MLKL  immune defense   Structure-based development of potent and selective type-II kinase inhibitors of RIPK1 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 1, 页码: 319-334 作者:  Qin, Ying;  Li, Dekang;  Qi, Chunting;  Xiang, Huaijiang;  Meng, Huyan   |  收藏  |  浏览/下载：23/0  |  提交时间：2024/03/06 RIPK1  Necroptosis  Type-II kinase inhibitors  Rational design  Lead optimization  Structure-activity relationship  Anti-inflammation  Preclinical drug discovery   Repurposing of the FGFR inhibitor AZD4547 as a potent inhibitor of necroptosis by selectively targeting RIPK1 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022 作者:  Wang, Zuo-wei;  Zou, Feng-ming;  Wang, Ao-li;  Yang, Jing;  Jin, Rui   |  收藏  |  浏览/下载：42/0  |  提交时间：2022/12/22 AZD4547  RIPK1  inhibitors  SIRS model  anti-necroptosis   The pathogenesis of organ fibrosis: Focus on necroptosis 期刊论文  OAI收割 BRITISH JOURNAL OF PHARMACOLOGY, 2022 作者:  Hao, Min;  Han, Xin;  Yao, Zhouhui;  Zhang, Han;  Zhao, Mengting   |  收藏  |  浏览/下载：56/0  |  提交时间：2022/12/22 liver fibrosis  lung fibrosis  MLKL  necroptosis  RIPK1  3  tissue fibrosis   Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis 期刊论文  OAI收割 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6 作者:  Yang, Xiangbo;  Lu, Huimin;  Xie, Hang;  Zhang, Binbin;  Nie, Tianqing   |  收藏  |  浏览/下载：42/0  |  提交时间：2022/01/18 Binding studies  Drug discovery  Necroptosis  RIPK1 inhibitors  Sepsis   A Conditionally Releasable "Do not Eat Me" CD47 Signal Facilitates Microglia-Targeted Drug Delivery for the Treatment of Alzheimer's Disease 期刊论文  OAI收割 ADVANCED FUNCTIONAL MATERIALS, 2020, 页码: 10 作者:  Zhang, Lun;  Liu, Xiao-ge;  Liu, Dong-qun;  Yu, Xiao-lin;  Zhang, Ling-xiao   |  收藏  |  浏览/下载：42/0  |  提交时间：2020/06/15 Alzheimer's Disease  Brain Delivery  Cd47  Microglia  Ripk1   RIPK1 inhibitor ameliorates colitis by directly maintaining intestinal barrier homeostasis and regulating following IECs-immuno crosstalk 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 172, 页码: 16 作者:  Lu, Huimin;  Li, Heng;  Fan, Chen;  Qi, Qing;  Yan, Yuxi   |  收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01 RIPK1 inhibitor  Colitis  Barrier homeostasis  IECs-immunocytes crosstalk  Necroptosis  NF-kappa B   Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 卷号: 115, 期号: 9, 页码: E2001-E2009 作者:  Meng, Huyan;  Liu, Zhen;  Li, Xingyan;  Wang, Huibing;  Jin, Taijie   |  收藏  |  浏览/下载：51/0  |  提交时间：2019/01/08 RIPK1  death domain  dimerization  necroptosis  RIPK1-dependent apoptosis