中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [14]
上海生物化学与细胞生... [9]
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期刊论文 [25]
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2024 [1]
2020 [1]
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Synthesis and biological evaluation of multimodal monoaminergic arylpiperazine derivatives with potential antidepressant profile
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 275, 页码: 16
作者:
Zheng, Jiefang
;
Zhou, Liping
;
Gong, Xudong
;
Yang, Feipu
;
Cheng, Jiaxin
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/08/22
Triple reuptake inhibitors
5-HT 1A R agonists
Antidepressants
Multimodal serotonergic compounds
Factor analysis of electroacupuncture and selective serotonin reuptake inhibitors for major depressive disorder: an 8-week controlled clinical trial
期刊论文
OAI收割
ACUPUNCTURE IN MEDICINE, 2020, 卷号: 38, 期号: 1, 页码: 45-52
作者:
Yang, Xinjing
;
Gong, Weijun
;
Ma, Xuehong
;
Wang, Sihan
;
Wang, Xueqin
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2020/03/30
electroacupuncture
major depressive disorder
Hamilton depression rating scale
anxiety
somatisation
selective serotonin reuptake inhibitors
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:
Liu, Wenwen
;
Wang, Huan
;
Li, Xiaokang
;
Xu, Yixiang
;
Zhang, Jian
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2019/01/08
Depression
Cognitive impairment
Multitarget-directed ligand
5-HT1A agonist
5-HT reuptake inhibition
ChE inhibition
Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721
作者:
Li, Xiaokang
;
Wang, Huan
;
Xu, Yixiang
;
Liu, Wenwen
;
Gong, Qi
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2019/01/08
Alzheimer's disease
depression
multitarget-directed ligand
ChE inhibition
5-HT1A agonist
5-HT reuptake inhibition
Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2012, 卷号: 54, 页码: 123-136
作者:
Zheng, Yong-Yong
;
Guo, Lin
;
Zhen, Xue-Chu
;
Li, Jian-Qi
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Arylalkanol-piperidine derivatives
Triple reuptake inhibitor
Antidepressant
Design,synthesis and bioactivity of aryl piperazine benzo[b]oxazine derivatives
期刊论文
OAI收割
Acta Pharmaceutica Sinica, 2012, 卷号: 47, 期号: 6, 页码: 755-763
作者:
Zheng Yongyong
;
Xie Peng
;
Zhang Jin
;
Li Jianqi
;
Guo Lin
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
5-HT_(1A)
aryl piperazine benzo [b] oxazine derivatives
pharmacophore model
5-HT reuptake
5-HT_(1A)
Fluoxetine inhibited extracellular matrix of pulmonary artery and inflammation of lungs in monocrotaline-treated rats
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2011, 卷号: 32, 期号: 2, 页码: 217-222
作者:
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/02/02
SMOOTH-MUSCLE-CELLS
SEROTONIN TRANSPORTER
HYPERTENSION
METALLOPROTEINASES
COLLAGENASE
EXPRESSION
PROTECTS
extracellular matrix
inflammation
pulmonary arterial hypertension
selective serotonin reuptake inhibitor
Classification of 5-HT_(1A) receptor agonists and antagonists using GA-SVM method
期刊论文
OAI收割
Acta Pharmacologica Sinica, 2011, 卷号: 32, 期号: 11, 页码: 1424
作者:
Zhu Xuelian
;
Cai Haiyan
;
Xu Zhijian
;
Wang Yong
;
Wang Heyao
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
VIVO PHARMACOLOGICAL EVALUATION
SEROTONIN TRANSPORTER AFFINITY
IN-VITRO
DUAL 5-HT1A
REUPTAKE INHIBITORS
LIGANDS
POTENT
DERIVATIVES
DISCOVERY
ANALOGS
5-HT1A receptor
support vector machine
genetic algorithm
agonist
antagonists
Design,synthesis and monoamine reuptake inhibitors activities of 4-aminopiperidine derivatives
期刊论文
OAI收割
Chinese Journal of Medicinal Chemistry, 2010, 卷号: 20, 期号: 6, 页码: 476-483
作者:
Zheng Yongyong
;
Yu Leiping
;
Guo Lin
;
Li Jianqi
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
4-aminopiperidine
monoamine reuptake inhibitor
synthesis
A novel compound N-1, N-5-(Z)-N-10-(E)-tri-p-coumaroylspermidine isolated from Carthamus tinctorius L. and acting by serotonin transporter inhibition
期刊论文
OAI收割
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2009, 卷号: 19, 期号: 10, 页码: 749-758
作者:
Zhao, Gang
;
Gai, Yue
;
Chu, Wen-Jing
;
Qin, Guo-Wei
;
Guo, Li-He
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Safflower
N-1,N-5-(Z)-N-10-(E)-tri-p-coumaroylspermidine
Serotonin transporter
Reuptake
Inhibitor