中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [8]
昆明植物研究所 [1]
过程工程研究所 [1]
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OAI收割 [10]
内容类型
期刊论文 [10]
发表日期
2025 [1]
2024 [3]
2023 [1]
2022 [1]
2014 [1]
2012 [1]
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学科主题
Biochemist... [1]
Chemistry [1]
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Design, synthesis and biological evaluation of Alisol B derivatives for potential treatment of non-alcoholic steatohepatitis
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 155, 页码: 15
作者:
Yu, Nai-Rong
;
Huang, Suling
;
Deng, Zhen-Tao
;
Wang, Jiayue
;
Shen, Yu
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/04/01
Non-alcoholic steatohepatitis (NASH)
Alisol B
Structural modification
Structure-activity relationship
HFD+CCl4-induced NASH mice model
Cytotoxic diterpenoids from
Croton
kongensis
inhibiting tumor proliferation and migration
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 152, 页码: 15
作者:
Zhu, Qiong
;
Li, Ying
;
Wang, Chenglei
;
Yu, Jinhai
;
Yue, Jianmin
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/10/21
Croton kongensis
ent-Kauranes
Structural elucidation
Structure-activity relationship
Anticancer mechanism
Intriguing steroid glycosides for cancer therapy by suppressing the DNA damage response and mTOR/S6K signaling pathways
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 151, 页码: 14
作者:
An, Pei-Pei
;
Huang, Hui
;
Ru, Su-Jie
;
Gao, Yuan
;
Ren, Yu-Hao
  |  
收藏
  |  
浏览/下载:91/0
  |  
提交时间:2024/09/26
Strophanthus divaricatus
Steroid glycosides
Structural elucidation
Structure-activity relationship
Anticancer mechanism
A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 107, 页码: 19
作者:
Wang, Xiaoyan
;
Yun, Ying
;
Chen, Lili
;
Guo, Shimeng
;
Niu, Buying
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/07/12
Diabetes
GLP-1 receptor
Agonist
Structural optimization
Water molecule replacement
Structure activity relationship
Docking simulation
Structurally modified Cyclovirobuxine-D Buxus alkaloids as effective analgesic agents through Cav3.2 T-Type calcium channel inhibition
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 135, 页码: 106493
作者:
Munikishore,Rachakunta
;
Liu,Rui
;
Zhang,Shuqun
;
Zhao,Qin-Shi
;
Nian,Yin
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/07/22
Buxus alkaloid
Structural modification
T -type calcium channel
Analgesic activity
Docking analysis
Structure -activity relationship study
BUXOZINE-C
SEMPERVIRENS
RING
CONSTITUTION
Design, synthesis and structural-activity relationship studies of phanginin A derivatives for regulating SIK1-cAMP/CREB signaling to suppress hepatic gluconeogenesis
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 232, 页码: 14
作者:
Wu, Xing-De
;
Huang, Suling
;
Shi, Yu
;
Shen, Yu
;
Tu, Wen-Chao
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2022/08/16
Hepatic gluconeogenesis
Type 2 diabetes
Phanginin A derivatives
SIK1
Structural-activity relationship
Design,synthesis and antiproliferative activity of 3-hydroxy-4-quinolone compounds
期刊论文
OAI收割
Journal of China Pharmaceutical University, 2014, 卷号: 45, 期号: 3, 页码: 286-292
作者:
Wang Fenghua
;
Wang Kai
;
Shen Jianhua
;
Chen Kaixian
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
3-hydroxy-4-quinolone
combination
synthesis
antiproliferative activity
structural-activity relationship
Discovery of structurally diverse and bioactive compounds from plant resources in China
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2012, 卷号: 33, 期号: 9, 页码: 1147-1158
作者:
Yang, Sheng-ping
;
Yue, Jian-min
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
natural products
plant resources
traditional Chinese medicine
bioactive compounds
structural modification
structure-activity relationship
Ring A-seco triterpenoids with antibacterial activity from Dysoxylum hainanense
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 卷号: 21, 期号: 1, 页码: 125-129
作者:
He, Xiu-Feng
;
Wang, Xiao-Ning
;
Yin, Sheng
;
Dong, Lei
;
Yue, Jian-Min
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Dysoxylum hainanense
Triterpenoids
Structural elucidation
Antibacterial activity
Structure-activity relationship
STRUCTURAL FRAME MODEL WITH NUMERICAL REPRESENTATION OF 2D MOLECULAR INFORMATION AND ITS APPLICATION
期刊论文
OAI收割
ACTA PHYSICO-CHIMICA SINICA, 1993, 卷号: 9, 期号: 1, 页码: 41-49
作者:
Zhou Jiaju
;
Xu Zhihong
;
Yan Xinjian
;
Sun Dunming
;
Cao Lingxiao
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2014/03/14
Structure-Activity Relationship
Processing of structural information
Herbicides
Sulfonylurea