机构

• 上海药物研究所 [8]
• 昆明植物研究所 [3]
• 长春应用化学研究所 [3]
• 上海神经科学研究所 [2]
• 中国科学院大学 [2]
• 金属研究所 [1]
• 更多

采集方式

• OAI收割 [23]
• iSwitch采集 [2]

内容类型

• 期刊论文 [25]

发表日期

• 2024 [2]
• 2023 [1]
• 2021 [2]
• 2020 [1]
• 2018 [3]
• 2017 [1]
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学科主题

• Biochemist... [1]
• Biochemist... [1]
• Chemistry [1]
• Developmen... [1]
• Life Scien... [1]
• Plant Scie... [1]
• 更多

筛选

浏览/检索结果: 共25条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Interaction-Based Inductive Bias in Graph Neural Networks: Enhancing Protein-Ligand Binding Affinity Predictions From 3D Structures 期刊论文  OAI收割 IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE, 2024, 卷号: 46, 期号: 12, 页码: 8191-8208 作者:  Yang, Ziduo;  Zhong, Weihe;  Lv, Qiujie;  Dong, Tiejun;  Chen, Guanxing   |  收藏  |  浏览/下载：17/0  |  提交时间：2025/01/14 Proteins  Programmable logic arrays  Three-dimensional displays  Predictive models  Graph neural networks  Data models  Convolution  Protein-ligand binding affinity  graph neural networks  inductive bias  drug-target interaction  structure-based virtual screening   Target Identification and Mechanistic Characterization of Indole Terpenoid Mimics: Proper Spindle Microtubule Assembly Is Essential for Cdh1-Mediated Proteolysis of CENP-A 期刊论文  OAI收割 ADVANCED SCIENCE, 2024, 页码: 14 作者:  Peng, Yan;  Zhang, Yumeng;  Fang, Ruan;  Jiang, Hao;  Lan, Gongcai   |  收藏  |  浏览/下载：38/0  |  提交时间：2024/07/12 Cdh1  CENP-A regulation  colchicine-binding site inhibitor  indole terpenoid  target identification   Structural insights into the interaction of three Y- shaped ligands with PI3Kα 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 34, 页码: 9 作者:  Zhou, Qingtong;  Liu, Xiao;  Neri, Dario;  Li, Wenxin;  Favalli, Nicholas   |  收藏  |  浏览/下载：33/0  |  提交时间：2023/12/08 phosphoinositide 3-kinase  drug target  ligand  binding pocket  chemical scaffold   Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis 期刊论文  OAI收割 PHARMACOLOGICAL RESEARCH, 2021, 卷号: 166, 页码: 105527 作者:  Zhou,Lutan;  Yin,Ronghua;  Gao,Na;  Sun,Huifang;  Chen,Dingyuan   |  收藏  |  浏览/下载：57/0  |  提交时间：2022/04/02 Oligosaccharides  Heparanase  Angiogenesis  Metastasis  FIBROBLAST-GROWTH-FACTOR  TUMOR-GROWTH  SULFATE PROTEOGLYCANS  MAMMALIAN HEPARANASE  COMBINATION  MECHANISMS  DISCOVERY  BINDING  TARGET  PI-88   Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963 作者:  Liu,Jiangxin;  Wu,Xing-De;  Li,Wenyan;  Yuan,Zaifeng;  Yang,Kun   |  收藏  |  浏览/下载：36/0  |  提交时间：2022/04/02 Pseudolaric acid A  Hsp90 inhibitor  Apoptosis  NMR  Structure-activity relationship  Photoaffinity-based probe  Protein-ligand interaction  MOLECULAR CHAPERONE  PROTEIN  TARGET  CANCER  KINASE  NMR  IDENTIFICATION  SELECTIVITY  BINDING  DESIGN   Identification of the target genes of AqAPETALA3-3 (AqAP3-3) in Aquilegia coerulea (Ranunculaceae) helps understand the molecular bases of the conserved and nonconserved features of petals 期刊论文  OAI收割 NEW PHYTOLOGIST, 2020, 卷号: 227, 期号: 4, 页码: 1235-1248 作者:  Jiang, Yongchao;  Wang, Meimei;  Zhang, Rui;  Xie, Jinghe;  Duan, Xiaoshan   |  收藏  |  浏览/下载：29/0  |  提交时间：2022/03/01 Aquilegia  binding sites  ChIP-seq  floral organ identity genes  petals  target genes   Pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity 期刊论文  OAI收割 JOURNAL OF FOOD AND DRUG ANALYSIS, 2018, 卷号: 26, 期号: 3, 页码: 965-972 作者:  Ma, Jiang;  Xia, Qingsu;  Fu, Peter P.;  Lin, Ge   |  收藏  |  浏览/下载：60/0  |  提交时间：2019/01/08 Pyrrolizidine alkaloids  Pyrrole-protein adducts  Covalent binding  Target protein  Mechanism-based biomarker  Clinical diagnosis   A novel class of microRNA-recognition elements that function only within open reading frames 期刊论文  OAI收割 NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2018, 卷号: 25, 期号: 11, 页码: 1019-+ 作者:  Zhang, Kai;  Cai, Zhiqiang;  Zhou, Jie;  Cao, Ran;  Chen, Zonggui   |  收藏  |  浏览/下载：61/0  |  提交时间：2019/04/28 Mediated Translational Repression  Messenger-rna Degradation  Human-cells  Mammalian Micrornas  Genomic Features  Binding Protein  Let-7 Microrna  Noncoding Rna  Coding Region  Target Sites   modifiedcitruspectininhibitedbladdertumorgrowththroughdownregulationofgalectin3 期刊论文  OAI收割 actapharmacologicasinica, 2018, 卷号: 39, 期号: 12, 页码: 1885 作者:  Fang Tian;  Liu Dandan;  Ning Heming;  Liu Dan;  Sun Jingya   |  收藏  |  浏览/下载：33/0  |  提交时间：2020/07/01 CANCER CELLS  APOPTOSIS  EXPRESSION  BINDING  PHOSPHORYLATION  PROGRESSION  STATISTICS  TARGET  AKT  modified citrus pectin  urinary bladder cancer  galectin-3  xenograft  cell survival   Discovery of a novel small inhibitor RJ19 targeting to human Hsp90 期刊论文  OAI收割 NUCLEAR SCIENCE AND TECHNIQUES, 2017, 卷号: 28, 期号: 10 作者:  Cao HuiLing;  Lyu KaiKai;  Liu Bin;  Li Jian;  He JianHua   |  收藏  |  浏览/下载：19/0  |  提交时间：2021/02/26 ATP HYDROLYSIS  PROTEIN  CHAPERONE  IDENTIFICATION  BINDING  DESIGN  Heat shock protein 90  Drug target  Inhibitor  X-ray diffraction  Complex crystal structure