中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [8]
昆明植物研究所 [1]
过程工程研究所 [1]
合肥物质科学研究院 [1]
植物研究所 [1]
采集方式
OAI收割 [12]
内容类型
期刊论文 [12]
发表日期
2022 [1]
2021 [1]
2019 [1]
2018 [1]
2017 [2]
2014 [2]
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学科主题
Biology [1]
Biophysics [1]
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Natural products for infectious microbes and diseases: an overview of sources, compounds, and chemical diversities
期刊论文
OAI收割
SCIENCE CHINA-LIFE SCIENCES, 2022, 卷号: 65, 期号: 6, 页码: 1123-1145
作者:
Luo, Lu
;
Yang, Jun
;
Wang, Cheng
;
Wu, Jie
;
Li, Yafang
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/03/07
natural product
infectious pathogen
drug discovery
drug development
in silico analysis
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15
作者:
Yu, Qing
;
Sun, Yi
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/03/15
anti-cancer drug
cullin-RING E3 ligases
natural product
high-throughput screen
neddylation
small-molecule inhibitors
A Strategy to Assess Quality Consistency of Drug Products
期刊论文
OAI收割
FRONTIERS IN CHEMISTRY, 2019, 卷号: 7, 页码: 7
作者:
Qi, Shu Y.
;
Yao, Shang C.
;
Yin, Li H.
;
Hu, Chang Q.
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/06/14
quality consistency
critical quality attribute
quality standard
process variation
assessment strategy
drug product
Oligosaccharides from depolymerized fucosylated glycosaminoglycan: Structures and minimum size for intrinsic factor Xase complex inhibition
期刊论文
OAI收割
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 36, 页码: 14089-14099
作者:
Yin, Ronghua
;
Zhou, Lutan
;
Gao, Na
;
Li, Zi
;
Zhao, Longyan
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2018/10/07
Natural Product
Carbohydrate Chemistry
Carbohydrate Structure
Chemical Modification
Drug Discovery
Oligosaccharide
Thrombosis
Advances in the study of berberine and its derivatives: a focus on anti-inflammatory and anti-tumor effects in the digestive system
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 2, 页码: 157-167
作者:
Zou, Kun
;
Li, Zhao
;
Zhang, Yong
;
Zhang, Hao-yue
;
Li, Bo
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/01/08
berberine
natural product
anti-inflammatory drug
anticancer drug
digestive system
structure-activity relationship
advancesinthestudyofberberineanditsderivativesafocusonantiinflammatoryandantitumoreffectsinthedigestivesystem
期刊论文
OAI收割
actapharmacologicasinica, 2017, 卷号: 38, 期号: 2, 页码: 157
作者:
Zou Kun
;
Li Zhao
;
Zhang Yong
;
Zhang Haoyue
;
Li Bo
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
berberine
natural product
anti-inflammatory drug
anticancer drug
digestive system
structure-activity relationship
Main points and inspirations of guidance for bioequivalence studies of oral solid products in European and American countries
期刊论文
OAI收割
Chinese Journal New Drugs, 2014, 卷号: 23, 期号: 13, 页码: 1501-1505
作者:
Zhang Yifan
;
Zhong Dafang
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
solid oral product
bioequivalence study
guidance
reference product
highly variable drug products
Discovery of a novel inhibitor of NAD(P)~+-dependent malic enzyme (ME2) by high-throughput screening
期刊论文
OAI收割
Acta Pharmacologica Sinica, 2014, 卷号: 35, 期号: 5, 页码: 674
作者:
Wen Yi
;
Xu Lei
;
Chen Fanglei
;
Gao Jing
;
Li Jingya
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/07/01
THERMAL SHIFT ASSAYS
STATISTICAL PARAMETER
QUALITY-CONTROL
DRUG DISCOVERY
RNAI SCREENS
PROGRESSION
MECHANISM
HIT
ATP
malic enzyme
ME2
inhibitor
natural product
NPD389
high-throughput screening
structure-activity relationship
enzyme kinetics
thermal shift assay
Microtubule-Binding Natural Products for Cancer Therapy
期刊论文
OAI收割
PLANTA MEDICA, 2010, 卷号: 76, 期号: 11, 页码: 1037-1043
作者:
Yue, Qing-Xi
;
Liu, Xuan
;
Guo, De-An
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
natural product
microtubule-binding agent
cancer
antiangiogenisis
drug resistance
marine sources
Drug discovery based on classic natural products
期刊论文
OAI收割
Acta Pharmaceutica Sinica, 2009, 卷号: 44, 期号: 1, 页码: 11-18
作者:
HU Li-hong
;
XU Ji-qing
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
drug discovery
classic natural product
molecular mechanism of action
structure-activity relationship study
resource study