机构

• 上海药物研究所 [5]
• 昆明植物研究所 [1]
• 上海生物化学与细胞生... [1]

采集方式

• OAI收割 [7]

内容类型

• 期刊论文 [7]

发表日期

• 2025 [2]
• 2023 [2]
• 2017 [1]
• 2015 [1]
• 2014 [1]

学科主题

• Hematology... [1]

筛选

浏览/检索结果: 共7条，第1-7条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Patients With Mild or Moderate Hepatic Impairment Versus Participants With Normal Hepatic Function: A Phase I Study 期刊论文  OAI收割 CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 7 作者:  Zhou, Jing;  Zhang, Hong;  Ding, Yanhua;  Wang, Zhen;  Wang, Yu   |  收藏  |  浏览/下载：4/0  |  提交时间：2025/06/23 hepatic impairment  pharmacokinetics  phosphodiesterase-5 inhibitor  TPN171   A Phase I Study to Evaluate the Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Adults with Renal Impairment 期刊论文  OAI收割 CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 8 作者:  Fu, Ping;  Song, Yi;  Hu, Chao;  Yong, Xiaolan;  Yu, Yang   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/06/23 pharmacokinetics  phosphodiesterase 5 inhibitor  renal impairment  safety  TPN171   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：44/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Discovery of 2-(Methylcarbonylamino) thiazole as PDE4 inhibitors via virtual screening and biological evaluation 期刊论文  OAI收割 JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 124, 页码: 108567 作者:  Ma,Rui;  Song,Na;  Wang,Lveli;  Gu,Xi;  Xiong,Feng   |  收藏  |  浏览/下载：14/0  |  提交时间：2024/07/22 PHOSPHODIESTERASE-4 INHIBITOR  ACCURATE DOCKING  APREMILAST  EFFICACY  INSIGHTS  DISEASE  ASTHMA  POTENT  GLIDE   Design and optimization of purine derivatives as in vivo active PDE10A inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 13, 页码: 3315-3329 作者:  Chen, Liu;  Chen, Danqi;  Tang, Le;  Ren, Jing;  Chen, Jiaojiao   |  收藏  |  浏览/下载：50/0  |  提交时间：2019/01/08 Phosphodiesterase  PDE10A  Purine  Inhibitor  Anti-psychotic   preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel 期刊论文  OAI收割 actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1528 作者:  Gao Zhiwei;  Zhu Yunting;  Yu Mingming;  Zan Bin;  Liu Jia   |  收藏  |  浏览/下载：24/0  |  提交时间：2020/07/01 HUMAN DRUG CLEARANCE  PHOSPHODIESTERASE-5 INHIBITORS  CLINICAL PHARMACOKINETICS  ERECTILE DYSFUNCTION  TISSUE DISTRIBUTION  ORAL PHARMACOKINETICS  RECEPTOR ANTAGONIST  DIVERSE COMPOUNDS  IN-VIVO  ABSORPTION  TPN729MA  PDE5 inhibitor  erectile dysfunction  pharmacokinetics  human PK prediction  physiologically based pharmacokinetic model   Salvianolic acid B inhibits platelets as a P2Y(12) antagonist and PDE inhibitor: Evidence from clinic to laboratory 期刊论文  OAI收割 THROMBOSIS RESEARCH, 2014, 卷号: 134, 期号: 4, 页码: 866-876 作者:  Liu, L;  Li, J;  Zhang, Y;  Zhang, SH;  Ye, JQ 收藏  |  浏览/下载：57/0  |  提交时间：2015/07/22 acute coronary syndrome  antiplatelet  P2Y(12) receptor antagonist  phosphodiesterase inhibitor  salvianolate