机构

• 上海药物研究所 [4]

采集方式

• OAI收割 [4]

内容类型

• 期刊论文 [4]

发表日期

• 2025 [2]
• 2023 [1]
• 2015 [1]

学科主题

筛选

浏览/检索结果: 共4条，第1-4条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择发表日期升序发表日期降序题名升序题名降序提交时间升序提交时间降序作者升序作者降序 Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Patients With Mild or Moderate Hepatic Impairment Versus Participants With Normal Hepatic Function: A Phase I Study 期刊论文  OAI收割 CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 7 作者:  Zhou, Jing;  Zhang, Hong   |  收藏  |  浏览/下载：10/0  |  提交时间：2025/06/23 hepatic impairment  pharmacokinetics  phosphodiesterase-5 inhibitor  TPN171   A Phase I Study to Evaluate the Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Adults with Renal Impairment 期刊论文  OAI收割 CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 8 作者:  Fu, Ping;  Song, Yi;  Hu, Chao;  Yong, Xiaolan;  Yu, Yang   |  收藏  |  浏览/下载：8/0  |  提交时间：2025/06/23 pharmacokinetics  phosphodiesterase 5 inhibitor  renal impairment  safety  TPN171   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：47/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel 期刊论文  OAI收割 actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1528 作者:  Gao Zhiwei;  Zhu Yunting;  Yu Mingming;  Zan Bin;  Liu Jia   |  收藏  |  浏览/下载：26/0  |  提交时间：2020/07/01 HUMAN DRUG CLEARANCE  PHOSPHODIESTERASE-5 INHIBITORS  CLINICAL PHARMACOKINETICS  ERECTILE DYSFUNCTION  TISSUE DISTRIBUTION  ORAL PHARMACOKINETICS  RECEPTOR ANTAGONIST  DIVERSE COMPOUNDS  IN-VIVO  ABSORPTION  TPN729MA  PDE5 inhibitor  erectile dysfunction  pharmacokinetics  human PK prediction  physiologically based pharmacokinetic model