中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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(2R,6R)-hydroxynorketamine alleviates PTSD-like endophenotypes by regulating the PI3K/AKT signaling pathway in rats
期刊论文
OAI收割
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2024, 卷号: 245, 页码: 16
作者:
Liu, Lifen
;
Li, Rui
;
Wu, Lanxia
;
Guan, Yubo
;
Miao, Miao
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2024/11/18
Post-traumatic stress disorder
Negative emotions
PI3K/AKT signaling pathway
(2R
6R)-HNK
Mass balance, metabolism, and pharmacokinetics of [
14
C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin's lymphoma, in healthy Chinese volunteers
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13
作者:
Zhao, Chun-Yang
;
Zhang, Li-Jun
;
Sun, Chan
;
Yu, Cheng-Yin
;
Wang, Jian
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/01/06
amdizalisib
PI3K delta kinase
metabolism
mass balance
metabolite identification
pharmacokinetics
safety
Berberine attenuates 5-fluorouracil-induced intestinal mucosal injury by modulating the gut microbiota without compromising its anti-tumor efficacy
期刊论文
OAI收割
HELIYON, 2024, 卷号: 10
作者:
Wu, Changhong
;
Yang, Jie
;
Ye, Chenxiao
;
Wu, Hui
;
Shu, Wenxi
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/11/22
5-Fluorouracil
Berberine
Intestinal mucositis
PI3K/AKT/mTOR pathway
Intestinal flora
LPS exacerbates TRPV4-mediated itch through the intracellular TLR4-PI3K signalling
期刊论文
OAI收割
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2024, 卷号: 28, 期号: 13, 页码: 9
作者:
Hao, Yanping
;
Wu, Liyan
;
Wang, Yuhui
;
Shan, Dongmei
;
Liu, Yifei
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/08/22
itch sensitization
LPS
PI3K
TLR4
TRPV4
Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathway
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13
作者:
Meng, Qian
;
Zhu, Hongwen
;
Li, Yuanyuan
;
Peng, Xiaotian
;
Wang, Tianming
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/05/07
Yinchenzhufu decoction
proteomics
cholestasis
liver fibrosis
PDGFR beta/PI3K/AKT
Inulin-like polysaccharide ABWW may impede CCl
4
induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway
in vitro
&
in vivo
期刊论文
OAI收割
CARBOHYDRATE POLYMERS, 2024, 卷号: 326, 页码: 15
作者:
Dai, Xiaolan
;
Du, Zhenyun
;
Jin, Can
;
Tang, Bixi
;
Chen, Xia
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2024/02/19
Fructan
Hepatic fibrosis
Hepatic stellate cells
FAK/PI3K/AKT
Quantitative relationships of
FAM50B
and
PTCHD3
methylation with reduced intelligence quotients in school aged children exposed to lead: Evidence from epidemiological and
in
vitro
studies
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 卷号: 907, 页码: 12
作者:
Wan, Cong
;
Ma, Huimin
;
Liu, Jiahong
;
Liu, Fei
;
Liu, Jing
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/09/14
DNA methylation biomarker
Intelligence quotient
Health risk assessment
FAM50B
PTCHD3
PI3K-AKT
Cryptotanshinone regulates gut microbiota and PI3K-AKT pathway in rats to alleviate CUMS induced depressive symptoms
期刊论文
OAI收割
BIOMEDICINE & PHARMACOTHERAPY, 2023, 卷号: 169, 页码: 11
作者:
Bian, Li-hua
;
Wang, Si-qi
;
Li, Wen-jing
;
Li, Jie
;
Yin, Yi
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/01/18
Depression
Cryptotanshinone
16 S rDNA
Transcriptomics
PI3K-AKT pathway
TPN10475 alleviates concanavalin A-induced autoimmune hepatitis by limiting T cell development and function through inhibition of PI3K-AKT pathway
期刊论文
OAI收割
INTERNATIONAL IMMUNOPHARMACOLOGY, 2023, 卷号: 125, 页码: 13
作者:
Wang, Chun
;
Han, Mengyao
;
Li, Xinhang
;
Lv, Jie
;
Zhuang, Wei
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/01/16
AIH
T cell
Pro-inflammatory
IFN-gamma
PI3K-AKT
Development of PI3Kγ selective inhibitors: the strategies and application
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 10
作者:
Gu, Dong-Yan
;
Zhang, Meng-Meng
;
Li, Jia
;
Zhou, Yu-Bo
;
Sheng, Rong
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/12/08
PI3K
PI3K gamma inhibitors
isoform selectivity
drug development
rational drug design