中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [82]
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OAI收割 [82]
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期刊论文 [79]
项目 [2]
学位论文 [1]
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2023 [10]
2022 [4]
2021 [2]
2020 [7]
2019 [6]
2018 [4]
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专题:上海药物研究所
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A novel pterostilbene compound DCZ0825 induces macrophage M1 differentiation and Th1 polarization to exert anti-myeloma and immunomodulatory
期刊论文
OAI收割
INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 卷号: 127, 页码: 14
作者:
Zhang, Hui
;
Hu, Ke
;
Lu, Yumeng
;
Xu, Zhijian
;
Chen, Gege
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/25
Multiple myeloma
M1 macrophages
Th1 cells
Immunomodulatory
From bench to bedside: current development and emerging trend of KRAS-targeted therapy
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18
作者:
Chen, Yi
;
Liu, Qiu-pei
;
Xie, Hua
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/01/16
KRAS mutation
KRAS(G12C) inhibitor
Pan-KRAS inhibitor
SHP2 allosteric inhibitor
SOS1 inhibitor
combination therapy
High-throughput design of energetic molecules
期刊论文
OAI收割
JOURNAL OF MATERIALS CHEMISTRY A, 2023, 卷号: 11, 期号: 45, 页码: 25031-25044
作者:
Liu, Jian
;
Zhao, Shicao
;
Duan, Bowen
;
He, Xudong
;
Yang, Chunming
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/19
Enantioselective Assembly of α, β-Diamine Acid Derivatives via Three-Component Reaction of α-H Diazoacetates with Sulfonamides and Imines
期刊论文
OAI收割
ADVANCED SYNTHESIS & CATALYSIS, 2023, 页码: 8
作者:
Sha, Hongkai
;
Xie, Xiongda
;
Zhang, Dan
;
Hu, Wenhao
;
Kang, Zhenghui
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/03/13
asymmetric three-component reaction
alpha, beta-diamine acid
metal carbenes
ammonium ylide
alpha-H diazoacetates
Support for this research from the National Natural Science Foundation of China (21901262, 92056201), Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery (2019B030301005), Natural Science Foundation of Guangdong Province, China (No. 2[21901262]
项目
OAI收割
项目编号: 21901262, 资助机构: Support for this research from the National Natural Science Foundation of China (21901262, 92056201), Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery (2019B030301005), Natural Science Foundation of Guangdong Province, China (No. 2, 2023-
-
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/13
Support for this research from the National Natural Science Foundation of China (21901262, 92056201), Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery (2019B030301005), Natural Science Foundation of Guangdong Province, China (No. 2[92056201]
项目
OAI收割
项目编号: 92056201, 资助机构: Support for this research from the National Natural Science Foundation of China (21901262, 92056201), Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery (2019B030301005), Natural Science Foundation of Guangdong Province, China (No. 2, 2023-
-
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/03/13
C-terminal modification and functionalization of proteins via a self-cleavage tag triggered by a small molecule
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 13
作者:
Zeng, Yue
;
Shi, Wei
;
Liu, Zhi
;
Xu, Hao
;
Liu, Liya
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/02/19
Structural insights into the interaction of three Y- shaped ligands with PI3Kα
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 34, 页码: 9
作者:
Zhou, Qingtong
;
Liu, Xiao
;
Neri, Dario
;
Li, Wenxin
;
Favalli, Nicholas
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/12/08
phosphoinositide 3-kinase
drug target
ligand
binding pocket
chemical scaffold
Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 9
作者:
Li, Hua-ying
;
Chen, Yi-li
;
Deng, Xiang-nan
;
Li, Huan-huan
;
Tan, Jie
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2023/10/17
cancer immunotherapy
B7-H3
PD-L1
bispecific antibodies
VHH
antibody-dependent cell-mediated cytotoxicity (ADCC)
Peptide-functionalized therapeutic nanoplatform for treatment orthotopic triple negative breast cancer and bone metastasis
期刊论文
OAI收割
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2023, 卷号: 50, 页码: 102669
作者:
Li, Daifeng
;
Ma, Shengnan
;
Xu, Denghui
;
Meng, Xiaocao
;
Lei, Ningjing
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/03/27
Triple-negative breast cancer
Epidermal growth factor receptor
Peptide-functionalized therapy
Peptide self-assembly
Nanoplatform