中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [44]
心理研究所 [3]
昆明动物研究所 [3]
中国科学院大学 [2]
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Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20
作者:
Yang, Wenjiao
;
Gong, Xudong
;
Sun, Haiguo
;
Wu, Chunhui
;
Suo, Jin
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/03/06
CB2R agonist
5-HT1AR agonist
CB1R antagonist
Antidepressant
Anxiolytic
Rhodium-Catalyzed Diastereoselective C-H Activation/[4+2] Annulation of
α,β
-Unsaturated Amides with Bicyclic Alkenes
期刊论文
OAI收割
ORGANIC LETTERS, 2024, 卷号: 26, 期号: 2, 页码: 483-487
作者:
Wang, Yan
;
Shi, Sijia
;
Zhang, Wei
;
Nian, Yong
;
Wu, Xiaowei
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/02/27
Targeting NMDA Receptors in Emotional Disorders: Their Role in Neuroprotection
期刊论文
OAI收割
BRAIN SCIENCES, 2022, 卷号: 12, 期号: 10, 页码: 17
作者:
Wang, Siqi
;
Bian, Lihua
;
Yin, Yi
;
Guo, Jianyou
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/11/27
NMDAR
depression
anxiety
neuroprotection
The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 229, 页码: 22
作者:
Li, Xiaokang
;
Li, Jinwen
;
Huang, Yunyuan
;
Gong, Qi
;
Fu, Yan
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/06/15
Alzheimer's disease
Depression
Comorbidity
Multi-target-directed ligands
New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Yong-Mei
;
Ye, Lu-Yu
;
Li, Tian-Yu
;
Guo, Fan
;
Guo, Fei
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/01/04
YL-0919
medial prefrontal cortex
GABAergic neurons
5-HT1A receptor
GAD67-GFP transgenic mice
disinhibition
fluoxetine
electrophysiological recording
Different conformational responses of the beta(2)-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline
期刊论文
OAI收割
NATIONAL SCIENCE REVIEW, 2021, 卷号: 8
作者:
Yang, Fan
;
Ling, Shenglong
;
Zhou, Yingxin
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/11/01
cryo-EM structure
G protein-coupled receptor (GPCR)
partial and full agonists
conformational change
desensitization
Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor
期刊论文
OAI收割
ELIFE, 2021, 卷号: 10, 页码: 20
作者:
Zhao, Fenghui
;
Zhang, Chao
;
Zhou, Qingtong
;
Hang, Kaini
;
Zou, Xinyu
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2021/08/17
TPN672: A Novel Serotonin-Dopamine Receptor Modulator for the Treatment of Schizophrenia
期刊论文
OAI收割
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 卷号: 378, 期号: 1, 页码: 20-30
作者:
Wang, Yu
;
He, Yang
;
Yang, Feipu
;
Abame, Melkamu Alemu
;
Wu, Chunhui
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/11/04
Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations
期刊论文
OAI收割
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, 卷号: 19, 页码: 3978-3989
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Liu, Huanxiang
;
Yao, Xiaojun
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/12/08
hGPR40
Positive binding cooperativity
Partial agonist
AgoPAM
Gaussian accelerated molecular dynamics simulation
Characterization of the GABAergic system in Asian clam Corbicula fluminea: Phylogenetic analysis, tissue distribution, and response to the aquatic contaminant carbamazepine
期刊论文
OAI收割
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2021, 卷号: 239
作者:
Chen, Huihui
;
Gu, Xiaohong
;
Zeng, Qingfei
;
Mao, Zhigang
;
Martyniuk, Christopher J.
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2022/03/10