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浏览/检索结果: 共231条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery and exploration of novel somatostatin receptor subtype 5 (SSTR5) antagonists for the treatment of cholesterol gallstones 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 16 作者:  Han, Fanghui;  Zhao, Tingting;  Zhang, Yanglong;  Yun, Ying;  Xu, Yuanyuan   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/02/19 SSTR5 antagonist  Gallbladder emptying  Cholesterol gallstones   Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua   |  收藏  |  浏览/下载：5/0  |  提交时间：2024/02/19 From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Physiological and Pathological Functions of TRPM7 Channel and Its Small-molecule Modulators 期刊论文  OAI收割 PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2023, 卷号: 50, 期号: 12, 页码: 2856-2868 作者:  Wang, Yun-Qi;  Guan, Zi-Yue;  Gao, Zhao-Bing;  Zheng, Yue-Ming   |  收藏  |  浏览/下载：11/0  |  提交时间：2024/04/09 TRPM7  ion channel  physiological function  disease  small molecule modulators   C-terminal modification and functionalization of proteins via a self-cleavage tag triggered by a small molecule 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 13 作者:  Zeng, Yue;  Shi, Wei;  Liu, Zhi;  Xu, Hao;  Liu, Liya   |  收藏  |  浏览/下载：6/0  |  提交时间：2024/02/19 Discovery of novel cGAS inhibitors based on natural flavonoids 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 14 作者:  Li, Jiameng;  Xiong, Muya;  Liu, Jiayuan;  Zhang, Fengping;  Li, Minjun   |  收藏  |  浏览/下载：8/0  |  提交时间：2023/12/08 Cyclic GMP-AMP synthase  Inhibitor  Flavonoids  Crystal structure  Virtual screening   Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 8, 页码: 6 作者:     |  收藏  |  浏览/下载：27/0  |  提交时间：2023/10/17 Activator  PTPs  Inhibitor  Thieno[2  b ]quinoline derivatives  Diffuse large B-cell lymphoma   Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells 期刊论文  OAI收割 SCIENCE ADVANCES, 2023, 卷号: 9, 期号: 35, 页码: 17 作者:  Bao, Weilian;  You, Yan;  Ni, Jiahui;  Hou, Hui;  Lyu, Jiaren   |  收藏  |  浏览/下载：6/0  |  提交时间：2023/12/08 Conserved class B GPCR activation by a biased intracellular agonist 期刊论文  OAI收割 NATURE, 2023, 页码: 25 作者:  Zhao, Li-Hua;  He, Qian;  Yuan, Qingning;  Gu, Yimin;  He, Xinheng   |  收藏  |  浏览/下载：10/0  |  提交时间：2023/10/17 Discovery of LL-K8-22: A Selective, Durable, and Small-Molecule Degrader of the CDK8-Cyclin C Complex 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 7, 页码: 4932-4951 作者:  Wang, Mingyu;  Lin, Rongkun;  Li, Jiacheng;  Suo, Yuying;  Gao, Jing   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17