中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [55]
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期刊论文 [195]
学位论文 [6]
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The new direction of drug development: Degradation of undruggable targets through targeting chimera technology
期刊论文
OAI收割
MEDICINAL RESEARCH REVIEWS, 2023, 页码: 54
作者:
Liang, Xuewu
;
Ren, Hairu
;
Han, Fengyang
;
Liang, Renwen
;
Zhao, Jiayan
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/01/16
chimeric design
degradation System
PROTAC
targeted degradation technology
undruggable targets
Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR plus Human Prostate Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 18, 页码: 13280-13303
作者:
Xiang, Weiguo
;
Zhao, Lijie
;
Han, Xin
;
Xu, Tianfeng
;
Kregel, Steven
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/12/08
Developmental regulation of the male urogenital papilla in the male marine teleost black rockfish, Sebastes schlegelii (Hilgendorf, 1880)
期刊论文
OAI收割
BIOLOGY OF REPRODUCTION, 2023, 页码: 13
作者:
Wang, Tao
;
Wang, Xueying
;
Zhao, Ning
;
Liu, Qinghua
;
Song, Zongcheng
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/07
androgen
external genitalia
viviparous
ara/arb/mafb/shha
Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer
期刊论文
OAI收割
CELL REPORTS, 2023, 卷号: 42, 期号: 7, 页码: 24
作者:
Li, Xiao
;
Li, Fei
;
Ye, Fei
;
Guo, Haotian
;
Chen, Wentao
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2023/10/17
Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 14, 页码: 9972-9991
作者:
Wang, Ao
;
Luo, Xianggang
;
Meng, Xin
;
Lu, Zhengyu
;
Chen, Kaixian
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/10/17
Discovery of HyT-Based Degraders of CDK9-Cyclin T1 Complex
期刊论文
OAI收割
CHEMISTRY & BIODIVERSITY, 2023, 页码: 10
作者:
Lin, Rongkun
;
Yang, Jie
;
Liu, Ting
;
Wang, Mingyu
;
Ke, Chongrong
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/10/17
CDK9
cyclin T1
degrader
hydrophobic tag
protein degradation
Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in cancer
期刊论文
OAI收割
CANCER CELL, 2023, 卷号: 41, 期号: 7, 页码: 1345-+
作者:
Wang, Hanling
;
Li, Ni
;
Liu, Qiuli
;
Guo, Jiacheng
;
Pan, Qiang
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/10/17
Design, Synthesis, and Evaluation of (R)-8-((Tetrahydrofuran-2-yl)methyl)pyrido[2,3-d]pyrimidin-7-ones as Novel Selective ACK1 Inhibitors to Combat Acquired Resistance to the Third-Generation EGFR Inhibitor
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 17
作者:
Li, Qian
;
Zhang, Tao
;
Song, Peiran
;
Tong, Linjiang
;
Feng, Fang
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/10/17
Morphology of the urogenital papilla of the male marine teleost Black Rockfish, Sebastes schlegelii (Hilgendorf, 1880), and its role in internal fertilization
期刊论文
OAI收割
JOURNAL OF MORPHOLOGY, 2023, 卷号: 284, 期号: 1, 页码: 10
作者:
Wang, Tao
;
Wang, Xueying
;
Zhao, Ning
;
Liu, Qinghua
;
Song, Zongcheng
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2023/12/13
androgens
external genitalia
fishes
viviparous
Pancreatic lipase-related protein 2 is selectively expressed by peritubular myoid cells in the murine testis and sustains long-term spermatogenesis
期刊论文
OAI收割
CELLULAR AND MOLECULAR LIFE SCIENCES, 2023, 卷号: 80, 期号: 8
作者:
Tao, Hai-Ping
;
Lu, Teng-Fei
;
Li, Shuang
;
Jia, Gong-Xue
;
Zhang, Xiao-Na
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2023/12/01