机构

• 上海药物研究所 [36]
• 过程工程研究所 [2]
• 上海生物化学与细胞生... [2]
• 武汉病毒研究所 [1]
• 昆明植物研究所 [1]
• 高能物理研究所 [1]
• 更多

采集方式

• OAI收割 [42]
• iSwitch采集 [3]

内容类型

• 期刊论文 [43]
• 学位论文 [2]

发表日期

• 2024 [1]
• 2023 [2]
• 2022 [5]
• 2021 [3]
• 2020 [3]
• 2019 [1]
• 更多

学科主题

• Hematology... [2]
• Biochemica... [1]
• Chemistry,... [1]
• Oncology [1]
• Pharmacolo... [1]

筛选

浏览/检索结果: 共45条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 20 作者:  Yang, Wenjiao;  Gong, Xudong;  Sun, Haiguo;  Wu, Chunhui;  Suo, Jin   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/03/06 CB2R agonist  5-HT1AR agonist  CB1R antagonist  Antidepressant  Anxiolytic   Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor gamma t (ROR gamma t) inverse agonists 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 18 作者:  Lu, Lixue;  Chen, Song;  Yu, Mingcheng;  Zhou, Ronghui;  Guo, Siqi   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/10/17 ROR gamma t  Triazines  Inverse agonist  Psoriasis  Autoimmune diseases   Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115213 作者:  Sun, Nannan;  Yu, Mingcheng;  Jiang, Zhengyuan;  Yang, Feng;  Lu, Lixue   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/03/27 ROR?t agonists  Carbazole carboxamide  Agonistic activity  Metabolic stability  Co-crystallization  Molecular docking   Molecular recognition of morphine and fentanyl by the human mu-opioid receptor 期刊论文  OAI收割 CELL, 2022, 卷号: 185, 期号: 23, 页码: 4361-+ 作者:  Zhuang, Youwen;  Wang, Yue;  He, Bingqing;  He, Xinheng;  Zhou, X. Edward   |  收藏  |  浏览/下载：14/0  |  提交时间：2023/04/10 Structure-Activity relationship study of benzothiophene oxobutanoic acid analogues leading to novel stimulator of interferon gene (STING) agonists 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 241, 页码: 16 作者:  Shen, Ancheng;  Li, Xiyuan;  Zhang, Yan;  Ma, Jing;  Xiao, Ruoxuan   |  收藏  |  浏览/下载：21/0  |  提交时间：2023/04/10 Innate immunity  STING Agonists  Structural modification  Immuno-oncology   PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way 期刊论文  OAI收割 JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 卷号: 10, 期号: 10, 页码: 15 作者:  Yu, Xiaolu;  Long, Yiru;  Chen, Binfan;  Tong, Yongliang;  Shan, Mengwen   |  收藏  |  浏览/下载：35/0  |  提交时间：2022/12/13 PD-L1  TLR7  nanobody-drug-conjugate  cancer immunotherapy   Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13 作者:  Darbalaei, Sanaz;  Chang, Ru-lue;  Zhou, Qing-tong;  Chen, Yan;  Dai, An-tao   |  收藏  |  浏览/下载：20/0  |  提交时间：2022/09/30 glucagon-like peptide-1 receptor  glucagon receptor  dual and triple agonist  cAMP  pERK1/2  unimolecular polypharmacology   Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 16 作者:  Zhao, Fenghui;  Zhou, Qingtong;  Cong, Zhaotong;  Hang, Kaini;  Zou, Xinyu   |  收藏  |  浏览/下载：38/0  |  提交时间：2022/06/15 GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11 作者:  Chen, Yan;  Xu, Ying-na;  Ye, Chen-yu   |  收藏  |  浏览/下载：16/0  |  提交时间：2022/06/15 NAFLD  NASH  GLP-1R  GLP-1 mimetics  dual agonists  triple agonists  GPCR   Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 8 作者:  Wang, Yu-zhe;  Yang, De-hua;  Wang, Ming-wei   |  收藏  |  浏览/下载：27/0  |  提交时间：2021/11/04 glucagon-like peptide-1 receptor  glucose-dependent insulinotropic peptide receptor  peptide 19  LY3298176  heteromerization  type 2 diabetes