中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [17]
西北高原生物研究所 [12]
上海营养与健康研究所 [8]
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Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221
作者:
He Yifei
;
Liu Yin
;
Yu Jinghua
;
Cheng Huan
;
Odilov Abdullajon
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/05/22
TPN171
14CTPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Parent and Halogenated Polycyclic Aromatic Hydrocarbons in the Serum of Coal-Fired Power Plant Workers: Levels, Sex Differences, Accumulation Trends, and Risks
期刊论文
OAI收割
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2022, 卷号: 56, 期号: 17, 页码: 12431-12439
作者:
Meng, Lingling
;
Li, Yingming
;
Zhao, Chuxuan
;
Li, An
;
Zhang, Gaoxin
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2022/11/08
MATERNAL SERUM
EXPOSURE
PAHS
LUNG
MIGRATION
SHANGHAI
PLACENTA
INVASION
SAMPLES
BLOOD
TPN171H alleviates pulmonary hypertension via inhibiting inflammation in hypoxia and monocrotaline-induced rats
期刊论文
OAI收割
VASCULAR PHARMACOLOGY, 2022, 卷号: 145, 页码: 11
作者:
Zhao, Congke
;
Hu, Liqing
;
He, Xiangrong
;
Li, Lijun
;
Yin, Minghui
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/08/16
Pulmonary hypertension
Hypoxia
Monocrotaline
Anti-inflammatory effects
NLRP3 inflammasome
Pulmonary artery endothelial cells
Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
He, Yi-fei
;
Liu, Yin
;
Yu, Jing-hua
;
Cheng, Huan
;
Odilov, Abdullajon
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/08/16
TPN171
[C-14]TPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Total flavones from Sceptridium ternatum alleviate pulmonary hypertension through inhibiting the proliferation of vascular endothelial cells
期刊论文
OAI收割
ANNALS OF TRANSLATIONAL MEDICINE, 2022
作者:
Li, Qinglin
;
Xin, Wenxiu
;
Ding, Haiyin
;
Zhang, Yiwen
;
Zheng, Xiaowei
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/12/23
Total flavones
pulmonary hypertension (PH)
HIF-?
JAK2-STAT3
Sceptridium ternatum
Efficacy and safety of anlotinib with and without EGFR-TKIs or immunotherapy in the treatment of elder patients with non-small-cell lung cancer: a retrospective study
期刊论文
OAI收割
BMC PULMONARY MEDICINE, 2022, 卷号: 22
作者:
Wang, Wenxian
;
Shao, Lan
;
Xu, Yibing
;
Song, Zhengbo
;
Lou, Guangyuan
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/12/23
Non-small cell lung cancer
Prognosis
Angiogenesis
Tyrosine kinase inhibitors
A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 10
作者:
Xu, Yingna
;
Feng, Wenbo
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/06/15
Simultaneous determination of monocrotaline and its N-oxide metabolite in rat plasma using LC-MS/MS: Application to a pharmacokinetic study
期刊论文
OAI收割
BIOMEDICAL CHROMATOGRAPHY, 2021, 页码: 7
作者:
Lin, Feifei
;
Pan, Anni
;
Ye, Yang
;
Liu, Jia
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2021/08/17
LC-MS
MS
monocrotaline
monocrotaline N-oxide
pharmacokinetics
A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959
作者:
Qian, Hongjie
;
Chen, Qian
;
Lang, Liyu
;
Zou, Yang
;
Pu, Huahua
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/08/17
TPN171H
PDE5 inhibitor
safety
pharmacokinetics
food effect
healthy subjects
Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 24, 页码: 15153-15186
作者:
Zheng, Wei
;
Wang, Zhen
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24