机构

• 上海药物研究所 [17]

采集方式

• OAI收割 [17]

内容类型

• 期刊论文 [17]

发表日期

• 2023 [1]
• 2022 [3]
• 2021 [2]
• 2020 [1]
• 2019 [2]
• 2018 [1]
• 更多

学科主题

• Biochemist... [1]
• Biophysics [1]
• Research &... [1]

筛选

浏览/检索结果: 共17条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221 作者:  He Yifei;  Liu Yin;  Yu Jinghua;  Cheng Huan;  Odilov Abdullajon   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/05/22 TPN171  14CTPN171  PDE5 inhibitor  pulmonary arterial hypertension  healthy volunteers  pharmacokinetics  metabolite identification  mass balance   TPN171H alleviates pulmonary hypertension via inhibiting inflammation in hypoxia and monocrotaline-induced rats 期刊论文  OAI收割 VASCULAR PHARMACOLOGY, 2022, 卷号: 145, 页码: 11 作者:  Zhao, Congke;  Hu, Liqing;  He, Xiangrong;  Li, Lijun;  Yin, Minghui   |  收藏  |  浏览/下载：30/0  |  提交时间：2022/08/16 Pulmonary hypertension  Hypoxia  Monocrotaline  Anti-inflammatory effects  NLRP3 inflammasome  Pulmonary artery endothelial cells   Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13 作者:  He, Yi-fei;  Liu, Yin;  Yu, Jing-hua;  Cheng, Huan;  Odilov, Abdullajon   |  收藏  |  浏览/下载：31/0  |  提交时间：2022/08/16 TPN171  [C-14]TPN171  PDE5 inhibitor  pulmonary arterial hypertension  healthy volunteers  pharmacokinetics  metabolite identification  mass balance   A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 10 作者:  Xu, Yingna;  Feng, Wenbo;  Zhou, Qingtong;  Liang, Anyi;  Li, Jie   |  收藏  |  浏览/下载：32/0  |  提交时间：2022/06/15 Simultaneous determination of monocrotaline and its N-oxide metabolite in rat plasma using LC-MS/MS: Application to a pharmacokinetic study 期刊论文  OAI收割 BIOMEDICAL CHROMATOGRAPHY, 2021, 页码: 7 作者:  Lin, Feifei;  Pan, Anni;  Ye, Yang;  Liu, Jia   |  收藏  |  浏览/下载：51/0  |  提交时间：2021/08/17 LC-MS  MS  monocrotaline  monocrotaline N-oxide  pharmacokinetics   A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects 期刊论文  OAI收割 DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959 作者:  Qian, Hongjie;  Chen, Qian;  Lang, Liyu;  Zou, Yang;  Pu, Huahua   |  收藏  |  浏览/下载：17/0  |  提交时间：2021/08/17 TPN171H  PDE5 inhibitor  safety  pharmacokinetics  food effect  healthy subjects   Targeted Drugs for Treatment of Pulmonary Arterial Hypertension: Past, Present, and Future Perspectives 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 24, 页码: 15153-15186 作者:  Zheng, Wei;  Wang, Zhen;  Jiang, Xiangrui;  Zhao, Qingjie;  Shen, Jingshan   |  收藏  |  浏览/下载：27/0  |  提交时间：2021/05/24 Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry 期刊论文  OAI收割 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310 作者:  Pan, Lulu;  Guo, Shuang;  Chen, Xiaoyan;  Jiang, Xiangrui;  Shen, Jingshan   |  收藏  |  浏览/下载：29/0  |  提交时间：2020/07/01 TPNI71  Metabolism  UPLC/Q-TOF MS  High-resolution mass spectrometry  Metabolite identification   Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990 作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei   |  收藏  |  浏览/下载：37/0  |  提交时间：2020/07/01 Pyrrole-protein adducts - A biomarker of pyrrolizidine alkaloid-induced hepatotoxicity 期刊论文  OAI收割 JOURNAL OF FOOD AND DRUG ANALYSIS, 2018, 卷号: 26, 期号: 3, 页码: 965-972 作者:  Ma, Jiang;  Xia, Qingsu;  Fu, Peter P.;  Lin, Ge   |  收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 Pyrrolizidine alkaloids  Pyrrole-protein adducts  Covalent binding  Target protein  Mechanism-based biomarker  Clinical diagnosis