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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [19]
昆明植物研究所 [2]
上海应用物理研究所 [2]
深圳先进技术研究院 [1]
西北高原生物研究所 [1]
上海营养与健康研究所 [1]
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OAI收割 [29]
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期刊论文 [29]
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2024 [1]
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2022 [1]
2021 [4]
2020 [2]
2019 [1]
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Chemistry [1]
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内容类型:期刊论文
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Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10
作者:
Chen, Guofeng
;
Xie, Hang
;
Liu, Jiayuan
;
Shao, Qiang
;
Li, Minjun
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/01/26
Methyl substitution
Selectivity
FABP4 inhibitor
Anti-inflammation
Metabolic stability
Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 253, 页码: 16
作者:
He, Yulong
;
Li, Shunyi
;
Zhu, Yueyue
;
Wang, Yujie
;
Chen, Yuqi
  |  
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2023/10/17
Structure-activity relationship
FABP4 inhibitor
Biphenyl scaffold
Selectivity
Oral bioavailability
Anti-inflammation
2,2 ',4,4 '-Tetrabromodiphenyl Ether (PBDE 47) Selectively Stimulates Proatherogenic PPAR gamma Signatures in Human THP-1 Macrophages to Contribute to Foam Cell Formation
期刊论文
OAI收割
CHEMICAL RESEARCH IN TOXICOLOGY, 2022, 卷号: 35, 期号: 6, 页码: 1023-1035
作者:
Ren, Qidong
;
Xie, Xinni
;
Zhao, Chuanfang
;
Wen, Qing
;
Pan, Ruiying
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2022/11/08
ACTIVATED-RECEPTOR-GAMMA
BROMINATED FLAME RETARDANTS
ACID-BINDING PROTEIN
GENE-EXPRESSION
LIGAND-BINDING
DIPHENYL ETHERS
INDOOR DUST
EXPOSURE
CD36
ACCUMULATION
Aurora Kinase A as a Diagnostic and Prognostic Marker of Malignant Mesothelioma
期刊论文
OAI收割
FRONTIERS IN ONCOLOGY, 2021, 卷号: 11
作者:
Guo, Zhenying
;
Shen, Li
;
Li, Ningning
;
Wu, Xiaoxiao
;
Wang, Canming
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2022/01/25
malignant mesothelioma
bioinformatics
biomarkers
tissue microarray
Aurora kinase A
Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14
作者:
He, Yu-Long
;
Chen, Meng-Ting
;
Wang, Ting
;
Zhang, Ming-Ming
;
Li, Ying-Xia
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/11/04
Type 2 diabetes mellitus
Dual FABP4/5 inhibitors
Anti-lipolytic and anti-inflammatory effects
Metabolic stability
Anti-diabetic activities
Combined treatment with FABP4 inhibitor ameliorates rosiglitazone-induced liver steatosis in obese diabetic db/db mice
期刊论文
OAI收割
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2021, 页码: 10
作者:
Chen, Meng-Ting
;
Huang, Jun-Shang
;
Gao, Ding-Ding
;
Li, Ying-Xia
;
Wang, He-Yao
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/08/17
combined treatment
FABP4 inhibitor
liver steatosis
obese type 2 diabetes
rosiglitazone
FPR2-based anti-inflammatory and anti-lipogenesis activities of novel meroterpenoid dimers from Ganoderma
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 105338
作者:
Peng,Xing-Rong
;
Wang,Qian
;
Wang,Hui-Rong
;
Hu,Kun
;
Xiong,Wen-Yong
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/04/02
Ganoderma applanatum
Meroterpenoid dimers
Molecular docking
Anti-lipogenesis
FPR2-based inflammation
INDUCED INSULIN-RESISTANCE
ADIPOCYTE DIFFERENTIATION
OBESITY
INFLAMMATION
DEFICIENCY
MACROPHAGES
ACTIVATION
EXPRESSION
LIGAND
MICE
Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4090-4106
作者:
Su, Haixia
;
Zou, Yi
;
Chen, Guofeng
;
Dou, Huixia
;
Xie, Hang
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2020/07/01
Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes
期刊论文
OAI收割
ENDOCRINE, 2020, 卷号: 67, 期号: 3, 页码: 587-596
作者:
Dou, Hui-Xia
;
Wang, Ting
;
Su, Hai-Xia
;
Gao, Ding-Ding
;
Xu, Ye-Chun
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
eFABP4
Adipocyte
Differentiation
Lipolysis
Inflammation
Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 19, 页码: 16
作者:
He, Yulong
;
Dou, Huixia
;
Gao, Dingding
;
Wang, Ting
;
Zhang, Mingming
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Dual FABP4/5 inhibitor
Structure-based design
Lipolysis inhibition
Anti-inflammatory effects