机构

• 上海药物研究所 [19]

采集方式

• OAI收割 [19]

内容类型

• 期刊论文 [19]

发表日期

• 2024 [1]
• 2023 [1]
• 2021 [2]
• 2020 [2]
• 2019 [1]
• 2018 [1]
• 更多

学科主题

• Chemistry [1]
• Pharmacolo... [1]

筛选

浏览/检索结果: 共19条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10 作者:  Chen, Guofeng;  Xie, Hang;  Liu, Jiayuan;  Shao, Qiang;  Li, Minjun   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/01/26 Methyl substitution  Selectivity  FABP4 inhibitor  Anti-inflammation  Metabolic stability   Optimization of potent, selective and orally bioavailable biphenyl scaffold as FABP4 inhibitors for anti-inflammation 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 253, 页码: 16 作者:  He, Yulong;  Li, Shunyi;  Zhu, Yueyue;  Wang, Yujie;  Chen, Yuqi   |  收藏  |  浏览/下载：62/0  |  提交时间：2023/10/17 Structure-activity relationship  FABP4 inhibitor  Biphenyl scaffold  Selectivity  Oral bioavailability  Anti-inflammation   Development of FABP4/5 inhibitors with potential therapeutic effect on type 2 Diabetes Mellitus 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 224, 页码: 14 作者:  He, Yu-Long;  Chen, Meng-Ting;  Wang, Ting   |  收藏  |  浏览/下载：46/0  |  提交时间：2021/11/04 Type 2 diabetes mellitus  Dual FABP4/5 inhibitors  Anti-lipolytic and anti-inflammatory effects  Metabolic stability  Anti-diabetic activities   Combined treatment with FABP4 inhibitor ameliorates rosiglitazone-induced liver steatosis in obese diabetic db/db mice 期刊论文  OAI收割 BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2021, 页码: 10 作者:  Chen, Meng-Ting;  Huang, Jun-Shang;  Gao, Ding-Ding;  Li, Ying-Xia;  Wang, He-Yao   |  收藏  |  浏览/下载：16/0  |  提交时间：2021/08/17 combined treatment  FABP4 inhibitor  liver steatosis  obese type 2 diabetes  rosiglitazone   Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4090-4106 作者:  Su, Haixia;  Zou, Yi;  Chen, Guofeng;  Dou, Huixia;  Xie, Hang   |  收藏  |  浏览/下载：22/0  |  提交时间：2020/07/01 Exogenous FABP4 interferes with differentiation, promotes lipolysis and inflammation in adipocytes 期刊论文  OAI收割 ENDOCRINE, 2020, 卷号: 67, 期号: 3, 页码: 587-596 作者:  Dou, Hui-Xia;  Wang, Ting;  Su, Hai-Xia;  Gao, Ding-Ding;  Xu, Ye-Chun   |  收藏  |  浏览/下载：31/0  |  提交时间：2020/07/01 eFABP4  Adipocyte  Differentiation  Lipolysis  Inflammation   Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 19, 页码: 16 作者:  He, Yulong;  Dou, Huixia;  Gao, Dingding;  Wang, Ting;  Zhang, Mingming   |  收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01 Dual FABP4/5 inhibitor  Structure-based design  Lipolysis inhibition  Anti-inflammatory effects   From hit to lead: Structure-based discovery of naphthalene-1 sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 154, 页码: 44-59 作者:  Gao, Ding-Ding;  Dou, Hui-Xia;  Su, Hai-Xia;  Zhang, Ming-Ming;  Wang, Ting   |  收藏  |  浏览/下载：28/0  |  提交时间：2019/01/08 FABP4 inhibitors  FABP3 sparing  Structure-based design strategy  X-ray crystallography   Combined Virtual Screening and Substructure Search for Discovery of Novel FABP4 Inhibitors 期刊论文  OAI收割 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2017, 卷号: 57, 期号: 9, 页码: 2329-2335 作者:  Cai, Haiyan;  Wang, Ting;  Yang, Zhuo;  Xu, Zhijian;  Wang, Guimin   |  收藏  |  浏览/下载：11/0  |  提交时间：2019/01/08 Novel fatty acid binding protein 4 (FABP4) inhibitors: Virtual screening, synthesis and crystal structure determination 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 卷号: 90, 页码: 241-250 作者:  Cai, Haiyan;  Liu, Qiufeng;  Gao, Dingding;  Wang, Ting;  Chen, Tiantian   |  收藏  |  浏览/下载：23/0  |  提交时间：2019/01/08 FABP4  Inhibitor  Diabetes  Virtual screening  Crystal structure