机构

• 上海药物研究所 [47]

采集方式

• OAI收割 [47]

内容类型

• 期刊论文 [44]
• 会议论文 [2]
• 学位论文 [1]

发表日期

• 2024 [1]
• 2023 [3]
• 2022 [1]
• 2021 [1]
• 2020 [4]
• 2019 [1]
• 更多

学科主题

• Chemistry [3]
• Biochemist... [1]
• Biotechnol... [1]
• Physics [1]

筛选

浏览/检索结果: 共47条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Selective FRET nano probe based on carbon dots and naphthalimide-isatin for the ratiometric detection of peroxynitrite in drug-induced liver injury 期刊论文  OAI收割 CHEMICAL SCIENCE, 2024, 卷号: 15, 期号: 2, 页码: 757-764 作者:  Wu, Yueci;  Sun, Lu-Lu;  Han, Hai-Hao;  He, Xiao-Peng;  Cao, Weiguo   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/01/26 Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor gamma t (ROR gamma t) inverse agonists 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 18 作者:  Lu, Lixue;  Chen, Song;  Yu, Mingcheng;  Zhou, Ronghui;  Guo, Siqi   |  收藏  |  浏览/下载：15/0  |  提交时间：2023/10/17 ROR gamma t  Triazines  Inverse agonist  Psoriasis  Autoimmune diseases   Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115213 作者:  Sun, Nannan;  Yu, Mingcheng;  Jiang, Zhengyuan;  Yang, Feng;  Lu, Lixue   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/03/27 ROR?t agonists  Carbazole carboxamide  Agonistic activity  Metabolic stability  Co-crystallization  Molecular docking   Discovery and mechanism of action of Thonzonium bromide from an FDA-approved drug library with potent and broad-spectrum inhibitory activity against main proteases of human coronaviruses 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 11 作者:  Wang, Ruyu;  Zhai, Guanglei;  Zhu, Guanghao;  Wang, Mengge;  Gong, Xiaoyi   |  收藏  |  浏览/下载：13/0  |  提交时间：2023/04/10 SARS-CoV-23CLpro  Thonzonium bromide  Mechanism of action  Broad-spectrum inhibitor   Recent progress in assays for GPCR drug discovery 期刊论文  OAI收割 AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2022, 卷号: 323, 期号: 2, 页码: C583-C594 作者:  Guo, Shimeng;  Zhao, Tingting;  Yun, Ying;  Xie, Xin   |  收藏  |  浏览/下载：10/0  |  提交时间：2023/04/10 biased signaling  GPCR  high -throughput screening assays  humanized mouse model  protein  protein interaction   A homogeneous time-resolved fluorometric energy transfer assay for the binding assessment of FcRn with IgG antibodies 期刊论文  OAI收割 JOURNAL OF IMMUNOLOGICAL METHODS, 2021, 卷号: 499, 页码: 6 作者:  Song, Yakai;  Deng, Xiaojie;  Shi, Wei;  Tang, Feng;  Huang, Wei   |  收藏  |  浏览/下载：38/0  |  提交时间：2022/01/04 FcRn  TR-FRET  mAb  ADC  Pharmacokinetics   Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7 作者:     |  收藏  |  浏览/下载：22/0  |  提交时间：2021/05/24 Drug design  CBP  Bromodomain  Inhibitor  Acute myeloid leukemia   Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 11 作者:  Chen, Yu;  Bi, Xiaoyang;  Zhang, Fengcai;  Sun, Zhongya;  Xu, Pan   |  收藏  |  浏览/下载：28/0  |  提交时间：2020/12/24 In silico screening  Drug design  CBP  Bromodomain  Inhibitor  Acute Myeloblastic Leukemia   An in vitro Fo''rster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10 作者:  Wang, Yu-zhe;  Liu, Xiao;  Way, George;  Madarha, Vipul;  Zhou, Qing-tong   |  收藏  |  浏览/下载：25/0  |  提交时间：2020/07/01 SUMOylation inhibitor  WNN0605-F008  high-throughput screening  Ubc9  PIAS1  Fo''rster resonance energy transfer  surface plasmon resonance   Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 2, 页码: 286-292 作者:  Zhang, Feng-cai;  Sun, Zhong-ya;  Liao, Li-ping;  Zuo, Yu;  Zhang, Dan   |  收藏  |  浏览/下载：49/0  |  提交时间：2020/07/01 CBP bromodomain  small-molecule inhibitor  high-throughput screening  TR-FRET  molecular modeling  human leukemia MV4-11 cells