中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [30]
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Discovery of GPX4 inhibitors through FP-based high-throughput screening
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 14
作者:
Cao, Yu
;
Wu, Bin
;
Xu, Ying
;
Wang, Mingchen
;
Wu, Xinyu
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/02/27
GPX4 inhibitor
HTS assay
Ferroptosis
Fluorescence polarization
Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors
期刊论文
OAI收割
CHEMICO-BIOLOGICAL INTERACTIONS, 2023, 卷号: 378, 页码: 11
作者:
Yang, Yun
;
Xiong, Yuan
;
Zhu, Guanghao
;
Sun, Mengru
;
Zou, Kun
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/10/17
Human carboxylesterase 2 (hCES2A)
Berberine analogues
Structure -activity relationships (SAR)
Inhibition kinetics
Selectivity
Synthesis and Biochemical Evaluation of 8H-Indeno[1,2-d]thiazole Derivatives as Novel SARS-CoV-2 3CL Protease Inhibitors
期刊论文
OAI收割
MOLECULES, 2022, 卷号: 27, 期号: 10, 页码: 11
作者:
Wu, Jing
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/08/16
COVID-19
M-pro inhibitors
drug design and synthesis
structure-activity relationships (SAR)
Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13
作者:
Meng, Xiang-Dong
;
Gao, Li-Xin
;
Wang, Zhi-Jia
;
Feng, Bo
;
Zhang, Chun
  |  
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2021/12/01
2,5-diphenyl-1,3,4-oxadiazole derivatives
SHP2
Inhibitors
Structure-activity relationships (SAR)
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging
期刊论文
OAI收割
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:
Liu, Xiao
;
Jiang, Shuang
;
Kong, Linghui
;
Ye, Rongrong
;
Xiao, Li
  |  
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2021/05/24
Morphinans
arylacetamidyl substituent
kappa opioid receptor modulators
structure-activity relationships
Synthesis and Structure-Activity Relationships of Ring-Opened Bengamide Analogues against Methicillin-Resistant Staphylococcus aureus(dagger)
期刊论文
OAI收割
CHINESE JOURNAL OF CHEMISTRY, 2021, 卷号: 39, 期号: 3, 页码: 671-676
作者:
Yu, Chen-Xi
;
Wei, Bing-Yan
;
Kong, Xue-Qing
;
Yang, Cai-Guang
;
Nan, Fa-Jun
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
Bengamides
Staphylococcus aureus
Antibiotics
Structure‐
activity relationships
Pharmacokinetic
Chemical Synthesis of the Nucleoside Antibiotic Capuramycin
期刊论文
OAI收割
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 2021, 期号: 26, 页码: 3681-3689
作者:
Xiao,Guozhi
;
He,Haiqing
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/04/02
Capuramycin
Chemical synthesis
Glycosyl ortho-(1-phenylvinyl)benzoates
One-pot glycosylation
Tuberculosis
DRUG-RESISTANT TUBERCULOSIS
GLUTAMIC-ACID-DERIVATIVES
MULTIDRUG-RESISTANT
PROTECTING GROUPS
IN-VITRO
GLYCOSYLATION
INHIBITORS
ALCOHOLS
ANALOGS
OXIDATION
Vacancies on 2D transition metal dichalcogenides elicit ferroptotic cell death
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2020, 卷号: 11, 期号: 1, 页码: 1-9
作者:
Xu, Shujuan
;
Zheng, Huizhen
;
Ma, Ronglin
;
Wu, Di
;
Pan, Yanxia
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/09/14
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 11, 页码: 5
作者:
Satheeshkumar, Rajendran
;
Zhu, Rui
;
Feng, Bo
;
Huang, Chao
;
Gao, Ya
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/07/01
Heterocyclic bis-aryl amides
PTP1B
SHP2
Inhibitors
Structure-activity relationships (SAR)
Synthesis of triazolotriazine derivatives as c-Met inhibitors
期刊论文
OAI收割
MOLECULAR DIVERSITY, 2020, 页码: 8
作者:
Guo, Yuting
;
Peng, Xia
;
Ji, Yinchun
;
Zhang, Yitong
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/12/24
Receptor tyrosine kinase
c-Met
Triazolotriazine
SAR
Cellular potency