中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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7-Dehydrocholesterol dictates ferroptosis sensitivity
期刊论文
OAI收割
NATURE, 2024, 卷号: 626, 期号: 7998, 页码: 29
作者:
Li, Yaxu
;
Ran, Qiao
;
Duan, Qiuhui
;
Jin, Jiali
;
Wang, Yanjin
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/04/09
Metabolite characterisation of the peptide-drug conjugate LN005 in liver S9s by UHPLC-Orbitrap-HRMS
期刊论文
OAI收割
XENOBIOTICA, 2024, 页码: 9
作者:
Yuan, Yali
;
Wang, Weiqiang
;
Luo, Jing
;
Tang, Chongzhuang
;
Zheng, Yuandong
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/02/19
peptide-drug conjugate
PDC
LN005
metabolite identification
liver S9s
Absorption, Distribution, Metabolism, and Excretion of [
14
C]BS1801, a Selenium-Containing Drug Candidate, in Rats
期刊论文
OAI收割
MOLECULES, 2023, 卷号: 28, 期号: 24, 页码: 16
作者:
Yang, Cheng
;
Xue, Mingzhen
;
He, Yifei
;
Yin, Hanwei
;
Yang, Chen
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/01/26
[C-14]BS1801
BS1801 (butaselen)
tissue distribution
metabolism
mass balance
selenium
Pharmacokinetic and metabolite profile of orally administered anemoside B4 in rats with an improved exposure in formulations of rectal suppository
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2023, 卷号: 315, 页码: 11
作者:
Ye, Yaqing
;
Xue, Mingzhen
;
Tian, Xiaoting
;
Gao, Hongwei
;
Hu, Pei
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2023/10/17
Anemoside B4
Pulsatilla chinensis
metabolite identification
Pharmacokinetics
Rectal suppository
Metabolic profiling of
Apostichopus japonicus
body wall exposed to a typical type of PBDEs: potential health risks and impact on sea cucumber health
期刊论文
OAI收割
FRONTIERS IN MARINE SCIENCE, 2023, 卷号: 10, 页码: 15
作者:
Ding, Kui
;
Zhuo, Pengji
;
Ge, Meiling
;
Liao, Xiaomei
;
Mo, Jing
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/11/30
sea cucumber
BDE-47
body wall
metabolite
metabolic pathway
EAT-2 attenuates C. elegans development via metabolic remodeling in a chemically defined food environment
期刊论文
OAI收割
CELLULAR AND MOLECULAR LIFE SCIENCES, 2023, 卷号: 80, 期号: 8, 页码: 18
作者:
Cao, Xuwen
;
Xie, Yusu
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2023/12/13
C. elegans maintenance medium CeMM
Development
Acetylcholine receptor
Fatty acid
C17ISO
S-adenosylmethionine SAM
Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221
作者:
He Yifei
;
Liu Yin
;
Yu Jinghua
;
Cheng Huan
;
Odilov Abdullajon
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2023/05/22
TPN171
14CTPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance
Changes in Disposition of Ezetimibe and Its Active Metabolites Induced by Impaired Hepatic Function: The Influence of Enzyme and Transporter Activities
期刊论文
OAI收割
PHARMACEUTICS, 2022, 卷号: 14, 期号: 12, 页码: 22
作者:
Xie, Ningjie
;
Wang, Hong
;
Qin, Hua
;
Guo, Zitao
;
Xue, Hao
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/04/10
hepatic impairment
ezetimibe
active metabolites
phase II enzymes
transporters
first-pass metabolism
inhibitory bile acids
Authentication of herbal medicines from multiple botanical origins with cross-validation mebabolomics, absolute quantification and support vector machine model, a case study of Rhizoma Alismatis
期刊论文
OAI收割
ARABIAN JOURNAL OF CHEMISTRY, 2022, 卷号: 15, 期号: 10, 页码: 8
作者:
Zhang, Jianqing
;
Wang, Cuicui
;
Wu, Wenyong
;
Jin, Qinghao
;
Wu, Jia
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2022/12/13
Rhizoma Alismatis
Alisma plantago-aquatica
Alisma orientale
Botanical origins
UHPLC/Orbitrap-MS
Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
He, Yi-fei
;
Liu, Yin
;
Yu, Jing-hua
;
Cheng, Huan
;
Odilov, Abdullajon
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/08/16
TPN171
[C-14]TPN171
PDE5 inhibitor
pulmonary arterial hypertension
healthy volunteers
pharmacokinetics
metabolite identification
mass balance