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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [20]
采集方式
OAI收割 [20]
内容类型
期刊论文 [20]
发表日期
2023 [2]
2022 [2]
2021 [2]
2020 [1]
2018 [1]
2017 [2]
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专题:上海药物研究所
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Discovery of a novel GPR35 agonist with high and equipotent species potency for oral treatment of IBD
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 96, 页码: 12
作者:
Song, Zhaoxiang
;
Lu, Dan
;
Sun, Jun
;
Ye, Yangliang
;
Fang, Jiahui
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/01/16
GPR35
IBD
Lodoxamide
The claustrum-prelimbic cortex circuit through dynorphin/κ-opioid receptor signaling underlies depression-like behaviors associated with social stress etiology
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 17
作者:
Wang, Yu-Jun
;
Zan, Gui-Ying
;
Xu, Cenglin
;
Li, Xue-Ping
;
Shu, Xuelian
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/02/19
Nrf2-mediated liver protection by 18 beta-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K/Akt/GSK3 beta pathway
期刊论文
OAI收割
PHYTOMEDICINE, 2022, 卷号: 102, 页码: 12
作者:
Wang, Zhangting
;
Ma, Jiang
;
He, Yisheng
;
Miu, Kai-Kei
;
Yao, Sheng
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2022/08/30
Pyrrolizidine alkaloids
Herb-induced liver injury
18 beta-glycyrrhetinic acid
Liquorice
Nuclear factor erythroid-2-related factor 2
PI3K/Akt/GSK3 beta
Liquorice Extract and 18 beta-Glycyrrhetinic Acid Protect Against Experimental Pyrrolizidine Alkaloid-Induced Hepatotoxicity in Rats Through Inhibiting Cytochrome P450-Mediated Metabolic Activation
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 页码: 14
作者:
Wang, Zhangting
;
Ma, Jiang
;
Yao, Sheng
;
He, Yisheng
;
Miu, Kai-Kei
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/06/15
18 beta-glycyrrhetinic acid
pyrrolizidine alkaloid
cytochrome P450
metabolic activation
competitive inhibition
A simultaneous identification and quantification strategy for determination of sulfhydryl-containing metabolites in normal- and high-fat diet hamsters using stable isotope labeling combined with LC-MS
期刊论文
OAI收割
ANALYTICA CHIMICA ACTA, 2021, 卷号: 1184, 页码: 13
作者:
Chang, Lu
;
Lin, Feifei
;
Cheng, Kai
;
Li, Jiaomeng
;
Sun, Xiaochu
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2022/01/18
Sulfhydryl-containing metabolites
Stable isotope labeling
Identification
Quantification
Hyperlipidemia
Oxidative stress
Sleeve gastrectomy ameliorated high-fat diet (HFD)-induced non-alcoholic fatty liver disease and upregulated the nicotinamide adenine dinucleotide +/ Sirtuin-1 pathway in mice
期刊论文
OAI收割
ASIAN JOURNAL OF SURGERY, 2021, 卷号: 44, 期号: 1, 页码: 213-220
作者:
Hua, Rong
;
Wang, Guan-Zhen
;
Shen, Qi-Wei
;
Yang, Ye-Ping
;
Wang, Meng
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2021/05/24
NAD
NAFLD
NRK1
SIRT1
Sleeve gastrectomy
Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 卷号: 59, 期号: 6, 页码: 2429-2439
作者:
Gao, Cheng-Long
;
Hou, Gui-Ge
;
Liu, Jin
;
Ru, Tong
;
Xu, Ya-Zhou
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
anti-inflammatory
drug discovery
heterocycles
photoaffinity labeling
proteins
Design, synthesis and structure activity relationship studies of GPR40 agonists containing amide linker
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 175-194
作者:
Chen, Tingting
;
Ning, Mengmeng
;
Ye, Yangliang
;
Wang, Kai
;
Leng, Ying
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
GPR40
FFAR1
Insulin secretion
Type 2 diabetes mellitus
CNS
Orally Administrated Small Molecule Drugs with Intestine Targeted Profile: Recent Development and Prospects
期刊论文
OAI收割
CURRENT MEDICINAL CHEMISTRY, 2017, 卷号: 24, 期号: 35, 页码: 3921-3937
作者:
Cao, Hua
;
Wang, Kai
;
Ye, Yang-Liang
;
Shen, Jian-Hua
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
Intestine targeted drugs
design strategies
lipophilicity
aqueous solubility
molecular weight
soft drugs
prodrugs
efflux transporters
Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 1, 页码: 56-68
作者:
Yang, Li-yun
;
Liu, Xiao-fang
;
Yang, Yang
;
Yang, Lin-lin
;
Liu, Kai-wen
  |  
收藏
  |  
浏览/下载:53/0
  |  
提交时间:2019/01/08
CD97
adhesion GPCR
auto-proteolysis
HeLa cell attachment
N-glycosylation