机构

• 上海药物研究所 [53]

采集方式

• OAI收割 [53]

内容类型

• 期刊论文 [53]

发表日期

• 2024 [2]
• 2023 [3]
• 2021 [1]
• 2020 [3]
• 2019 [3]
• 2018 [5]
• 更多

学科主题

筛选

浏览/检索结果: 共53条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 144, 页码: 18 作者:  Zhuo, Ning;  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Yin, Jianpeng   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/03/25 Type 2 Diabetes  TGR5 agonist  Betulinic acid  Gut-restricted  Gallbladder-filling effects  Kinetophores   Design and process study of chiral separation of (2S,4S)-1-(tert-butoxy carbonyl)-4-(methoxymethyl) pyrrolidine-2-carboxylic acid for green manufacturing 期刊论文  OAI收割 GREEN CHEMISTRY, 2024, 页码: 11 作者:  Ge, Shuwang;  Fu, Mingwei;  Gu, Dihai;  Wei, Lai;  Qian, Kun   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/02/27 Nanolobatone A, An Unprecedented Diterpenoid and Related New Casbanoids from the Hainan Soft Coral Sinularia nanolobata 期刊论文  OAI收割 CHEMISTRY-A EUROPEAN JOURNAL, 2023, 卷号: 29, 期号: 26 作者:  Liu, Jiao;  Li, Song-Wei;  Zhao, Qing-Min;  Zhang, Zai-Yong;  Yao, Li-Gong   |  收藏  |  浏览/下载：1/0  |  提交时间：2024/03/27 bioactivity  diterpenoid  Sinularia  soft coral  stereochemistry   Unsymmetrical Phosphodiesters as GPR84 Antagonists with High Blood Exposure for the Treatment of Lung Inflammation 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 8, 页码: 5820-5838 作者:  Li, Shao-Xian;  Wang, Si-Wei;  Chen, Lin-Hai;  Zhang, Qing;  Lu, Dan   |  收藏  |  浏览/下载：3/0  |  提交时间：2024/03/27 Development of the novel ACLY inhibitor 326E as a promising treatment for hypercholesterolemia 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 2, 页码: 739-753 作者:  Xie, Zhifu;  Zhang, Mei;  Song, Qian;  Cheng, Long;  Zhang, Xinwen   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/03/27 Hypercholesterolemia  Atherosclerosis  Liver  ATP-Citrate lyase (ACLY)  Lipogenesis  Cholesterol efflux  ACLY inhibitor   Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5(H88Y) Mutant Mice 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12181-12199 作者:  Yun, Ying;  Zhang, Chenlu;  Guo, Shimeng;  Liang, Xiaoying;  Lan, Yuan   |  收藏  |  浏览/下载：42/0  |  提交时间：2021/11/04 Erectsterates A and B, a pair of novel highly degraded steroid derivatives from the South China Sea soft coral Sinularia erecta 期刊论文  OAI收割 STEROIDS, 2020, 卷号: 161, 页码: 5 作者:  Liu, Jiao;  Wu, Xin;  Yang, Min;  Gu, Yu-Cheng;  Yao, Li-Gong   |  收藏  |  浏览/下载：18/0  |  提交时间：2020/12/24 Sinularia erecta  Steroidal derivative  Cytotoxicity  Baeyer-Villiger oxidation   Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 卷号: 41, 期号: 3, 页码: 293-302 作者:  Wang, Jin-tao;  Zheng, Yue-ming;  Chen, Yue-ting;  Gu, Min;  Gao, Zhao-bing   |  收藏  |  浏览/下载：29/0  |  提交时间：2020/07/01 Nav1  7 sodium channel  aryl sulfonamide  maprotiline  compound 10o  electrophysiology  acetic acid-induced visceral pain  analgesic activity   Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12 作者:  Liu, Yi;  Zhu, Ke-xin;  Cao, Lei;  Xie, Zhi-fu;  Gu, Min   |  收藏  |  浏览/下载：20/0  |  提交时间：2020/07/01 berberine  anticancer  membrane permeability  apoptosis  mitochondria   A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer 期刊论文  OAI收割 CELL METABOLISM, 2019, 卷号: 30, 期号: 6, 页码: 1107-+ 作者:  Huang, Ke;  Liang, Qian;  Zhou, Ye;  Jiang, Lu-lu;  Gu, Wei-ming   |  收藏  |  浏览/下载：81/0  |  提交时间：2020/07/01