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The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 229, 页码: 22
作者:  Li, Xiaokang
  |  收藏  |  浏览/下载：31/0  |  提交时间：2022/06/15
Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3 期刊论文  OAI收割
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 10, 页码: 3206-3219
作者:  Lu, Tian;  Li, Yong;  Lu, Wenchao;  Spitters, Twgm;  Fang, Xueyu
  |  收藏  |  浏览/下载：45/0  |  提交时间：2021/12/01
Novel bivalent BET inhibitor N2817 exhibits potent anticancer activity and inhibits TAF1 期刊论文  OAI收割
BIOCHEMICAL PHARMACOLOGY, 2021, 卷号: 185, 页码: 14
作者:  Wu, Qian;  Chen, Dan-Qi;  Sun, Lin;  Huan, Xia-Juan;  Bao, Xu-Bin
  |  收藏  |  浏览/下载：39/0  |  提交时间：2021/05/24
A new BET inhibitor, 171, inhibits tumor growth through cell proliferation inhibition more than apoptosis induction 期刊论文  OAI收割
INVESTIGATIONAL NEW DRUGS, 2020, 卷号: 38, 期号: 3, 页码: 700-713
作者:  Damaneh, Mohammadali Soleimani;  Hu, Jian-Ping;  Huan, Xia-Juan;  Song, Shan-Shan;  Tian, Chang-Qing
  |  收藏  |  浏览/下载：41/0  |  提交时间：2020/07/01
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment 期刊论文  OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:  Liu, Wenwen;  Wang, Huan;  Li, Xiaokang;  Xu, Yixiang;  Zhang, Jian
  |  收藏  |  浏览/下载：37/0  |  提交时间：2019/01/08
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5) 期刊论文  OAI收割
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636
作者:  Ni, Wei;  Wang, Huan;  Li, Xiaokang;  Zheng, Xinyu;  Wang, Manjiong
  |  收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08
Discovery of novel propargylamine-modified 4-aminoalkyl imidazole substituted pyrimidinylthiourea derivatives as multifunctional agents for the treatment of Alzheimer's disease 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 33-47
作者:  Xu, Yi-xiang;  Wang, Huan;  Li, Xiao-kang;  Dong, Sheng-nan;  Liu, Wen-wen
  |  收藏  |  浏览/下载：27/0  |  提交时间：2019/01/08
Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation 期刊论文  OAI收割
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721
作者:  Li, Xiaokang;  Wang, Huan;  Xu, Yixiang;  Liu, Wenwen;  Gong, Qi
  |  收藏  |  浏览/下载：36/0  |  提交时间：2019/01/08
Discovery of potent 2,4-difluoro-linker poly(ADP-ribose) polymerase 1 inhibitors with enhanced water solubility and in vivo anticancer efficacy 期刊论文  OAI收割
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 11, 页码: 1521-1532
作者:  Chen, Wen-hua;  Song, Shan-shan;  Qi, Ming-hui;  Huan, Xia-juan;  Wang, Ying-qing
  |  收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08
Discovery, mechanism and metabolism studies of 2,3-difluorophenyl-linker-containing PARP1 inhibitors with enhanced in vivo efficacy for cancer therapy 期刊论文  OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 138, 页码: 514-531
作者:  Chen, Wenhua;  Guo, Ne;  Qi, Minghui;  Dai, Haiying;  Hong, Minghuang
  |  收藏  |  浏览/下载：29/0  |  提交时间：2019/01/08