机构

• 上海药物研究所 [39]
• 西北高原生物研究所 [9]
• 自动化研究所 [8]
• 天津工业生物技术研究... [2]
• 兰州化学物理研究所 [2]
• 深圳先进技术研究院 [1]
• 更多

采集方式

• OAI收割 [64]

内容类型

• 期刊论文 [56]
• 会议论文 [8]

发表日期

• 2024 [3]
• 2023 [15]
• 2022 [11]
• 2021 [6]
• 2020 [5]
• 2018 [2]
• 更多

学科主题

筛选

浏览/检索结果: 共64条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Potency Prediction of Covalent Inhibitors against SARS-CoV-2 3CL-like Protease and Multiple Mutants by Multiscale Simulations 期刊论文  OAI收割 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2024, 卷号: 64, 期号: 24, 页码: 9501-9516 作者:  Xiong, Muya;  Nie, Tianqing;  Li, Zhewen;  Hu, Meiyi;  Su, Haixia   |  收藏  |  浏览/下载：4/0  |  提交时间：2025/01/06 Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CLpro Inhibitors as anti-SARS-CoV-2 Drug Candidate 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 15, 页码: 12760-12783 作者:  Jiang, Zhidong;  Feng, Bo;  Chen, Lu;  Nie, Tianqing;  Chen, Shizhao   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/09/26 Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10 作者:  Chen, Guofeng;  Xie, Hang;  Liu, Jiayuan;  Shao, Qiang;  Li, Minjun   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/01/26 Methyl substitution  Selectivity  FABP4 inhibitor  Anti-inflammation  Metabolic stability   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：32/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15 作者:  Jiang, Xiangrui;  Su, Haixia;  Shang, Weijuan;  Zhou, Feng;  Zhang, Yan   |  收藏  |  浏览/下载：35/0  |  提交时间：2024/03/25 Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 13 作者:  Yang, Hanxi;  You, Mengyuan;  Shu, Xiaoyang;  Zhen, Jingyao;  Zhu, Mengwei   |  收藏  |  浏览/下载：25/0  |  提交时间：2023/10/17 Peptidomimetics  Benzothiazolyl ketone  3CLpro inhibitor  Pharmacokinetic properties  SARS-CoV-2   Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 18 作者:  Ren, Pengxuan;  Li, Hui;  Nie, Tianqing;  Jian, Xiaoqin;  Yu, Changyue   |  收藏  |  浏览/下载：17/0  |  提交时间：2023/10/17 Multi-omics for COVID-19: driving development of therapeutics and vaccines 期刊论文  OAI收割 NATIONAL SCIENCE REVIEW, 2023, 卷号: 10, 期号: 9, 页码: 30 作者:  Guo, Mengyu;  Xiong, Muya;  Peng, Jinying;  Guan, Tong;  Su, Haixia   |  收藏  |  浏览/下载：12/0  |  提交时间：2023/12/19 COVID-19  SARS-CoV-2  multi-omics  antibodies  small-molecule drugs  vaccines   Discovery of novel non-peptidic and non-covalent small-molecule 3CL(pro) inhibitors as potential candidate for COVID-19 treatment 期刊论文  OAI收割 SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 卷号: 8, 期号: 1, 页码: 4 作者:  Jiang, Zhidong;  Feng, Bo;  Zhang, Yumin;  Nie, Tianqing;  Liu, Hong   |  收藏  |  浏览/下载：16/0  |  提交时间：2023/10/17 Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease 期刊论文  OAI收割 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 10, 页码: 15 作者:  Wang, Qian;  Chen, Guofeng;  He, Jian;  Li, Jiameng;  Xiong, Muya   |  收藏  |  浏览/下载：31/0  |  提交时间：2023/10/17 SARS-CoV-2  papain-like protease  covalent inhibitor  co-crystal structure  in vitro assay