机构

• 上海药物研究所 [43]
• 西北高原生物研究所 [9]
• 自动化研究所 [8]
• 天津工业生物技术研究... [2]
• 兰州化学物理研究所 [2]
• 深圳先进技术研究院 [1]
• 更多

采集方式

• OAI收割 [68]

内容类型

• 期刊论文 [60]
• 会议论文 [8]

发表日期

• 2025 [4]
• 2024 [3]
• 2023 [15]
• 2022 [11]
• 2021 [6]
• 2020 [5]
• 更多

学科主题

筛选

浏览/检索结果: 共68条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Identification of RIPK3 as a target of flavonoids for anti-necroptosis in vitro 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2025, 卷号: 161, 页码: 11 作者:  Xie, Hang;  Li, Wanchen;  Han, Xiaoyu;  Li, Minjun;  Zhao, Qiang   |  收藏  |  浏览/下载：15/0  |  提交时间：2025/07/25 RIPK3  Inhibitors  Flavonoids  Co-crystal structure  Anti-necroptosis effect   De novo design of protein condensation inhibitors by targeting an allosteric site of cGAS 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 20 作者:  Zhao, Wenfeng;  Chen, Guofeng;  He, Jian;  Shen, Xiaofang;  Xiong, Muya   |  收藏  |  浏览/下载：4/0  |  提交时间：2025/08/20 Development of Orally Bioavailable Octahydroindole-Based Peptidomimetic Derivative as a Broad-Spectrum Inhibitor against HCoV-OC43 and SARS-CoV-2 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 11, 页码: 10823-10844 作者:  Hu, Shulei;  Zhang, Yumin;  Wang, Chenchen;  Li, Jian;  Su, Haixia   |  收藏  |  浏览/下载：18/0  |  提交时间：2025/07/25 Dynamic Cap-Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease 期刊论文  OAI收割 ADVANCED SCIENCE, 2025, 页码: 13 作者:  Su, Haixia;  Wu, Guoqing;  Xiong, Muya;  Wang, Yuhang;  Cao, Junyuan   |  收藏  |  浏览/下载：11/0  |  提交时间：2025/05/27 covalent inhibitors  I7L protease  monkeypox virus  protein structures  substrate proteolysis   Potency Prediction of Covalent Inhibitors against SARS-CoV-2 3CL-like Protease and Multiple Mutants by Multiscale Simulations 期刊论文  OAI收割 JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2024, 卷号: 64, 期号: 24, 页码: 9501-9516 作者:  Xiong, Muya;  Nie, Tianqing;  Li, Zhewen;  Hu, Meiyi;  Su, Haixia   |  收藏  |  浏览/下载：18/0  |  提交时间：2025/01/06 Discovery of Novel Nonpeptidic and Noncovalent Small Molecule 3CLpro Inhibitors as anti-SARS-CoV-2 Drug Candidate 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 15, 页码: 12760-12783 作者:  Jiang, Zhidong;  Feng, Bo;  Chen, Lu;  Nie, Tianqing;  Chen, Shizhao   |  收藏  |  浏览/下载：43/0  |  提交时间：2024/09/26 Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10 作者:  Chen, Guofeng;  Xie, Hang;  Liu, Jiayuan;  Shao, Qiang;  Li, Minjun   |  收藏  |  浏览/下载：34/0  |  提交时间：2024/01/26 Methyl substitution  Selectivity  FABP4 inhibitor  Anti-inflammation  Metabolic stability   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang;  Zou, Yi   |  收藏  |  浏览/下载：47/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir 期刊论文  OAI收割 NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15 作者:  Jiang, Xiangrui;  Su, Haixia;  Shang, Weijuan;  Zhou, Feng;  Zhang, Yan   |  收藏  |  浏览/下载：52/0  |  提交时间：2024/03/25 Design, synthesis and biological evaluation of peptidomimetic benzothiazolyl ketones as 3CLpro inhibitors against SARS-CoV-2 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 13 作者:  Yang, Hanxi;  You, Mengyuan;  Shu, Xiaoyang;  Zhen, Jingyao;  Zhu, Mengwei   |  收藏  |  浏览/下载：37/0  |  提交时间：2023/10/17 Peptidomimetics  Benzothiazolyl ketone  3CLpro inhibitor  Pharmacokinetic properties  SARS-CoV-2