中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [34]
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期刊论文 [65]
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Design, Synthesis, and Structure-Activity Relationship of Novel Potent and Highly Selective Cysteinyl Leukotriene Receptor 1 (CysLT1R) Antagonists
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 44, 期号: 1, 页码: 259-276
作者:
Wang Jingyi
;
Liu Jinyu
;
Chen Dongsheng
;
Chen Huayan
;
Xie Xin
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/05/07
cysteinyl leukotriene
cysteinyl leukotriene receptor 1 (CysLT1R)
selective antagonists
Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR & gamma; antagonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 15
作者:
Mei, Lianghe
;
Xu, Lansong
;
Wu, Sanan
;
Wang, Yafang
;
Xu, Chao
  |  
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2023/10/17
Betulinic acid
ROR & gamma
Target identification
Rationale structure optimization
Anti-tumor effects
antagonists
11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E-2/ER beta signaling pathways
期刊论文
OAI收割
PHYTOTHERAPY RESEARCH, 2023, 页码: 17
作者:
Lyu, Yan
;
Wei, Xiaojia
;
Yang, Xue
;
Li, Jiayuan
;
Wan, Guohui
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/10/09
11-ethoxyviburtinal
antagonists
anxiety disorder
estrogen receptor beta
PI3K-Akt signaling pathway
the male and female mice
Simulating androgen receptor selection in designer yeast
期刊论文
OAI收割
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022, 卷号: 7
作者:
Zhang, Haoran
;
Zhang, Lu
;
Xu, Yipeng
;
Chen, Shaoyong
;
Ma, Zhenyi
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2022/12/23
Androgen receptor mutations
Androgen receptor antagonists
Prostate cancer
Saccharomyces cerevisiae
Glycan Epitopes and Potential Glycoside Antagonists of DC-SIGN Involved in COVID-19: In Silico Study
期刊论文
OAI收割
BIOMOLECULES, 2021, 卷号: 11, 期号: 11, 页码: 16
作者:
Gao, Meina
;
Li, Hui
;
Ye, Chenghao
;
Chen, Kaixian
;
Jiang, Hualiang
  |  
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2022/01/04
DC-SIGN
glycan epitopes
carbohydrate recognition mechanism
natural glycoside antagonists
molecular dynamics simulations
COVID-19
Supramolecular Antagonists Promote Mitochondrial Dysfunction
期刊论文
OAI收割
NANO LETTERS, 2021, 卷号: 21, 期号: 13, 页码: 5730-5737
作者:
Li, Mingming
;
Song, Yanqiu
;
Song, Na
;
Wu, Guangyao
;
Zhou, Hao
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/08/17
Self-Assembly
Peptides
Drug Delivery
Mitochondrion-Targeting
Antagonists
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 31, 页码: 13
作者:
Wang, Ao
;
Wang, Yawan
;
Meng, Xin
;
Yang, Yushe
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
Androgen receptor
Novel thiohydantoin derivatives
Androgen receptor antagonists
Prostate cancer
Label-free cell phenotypic study of opioid receptors and discovery of novel mu opioid ligands from natural products
期刊论文
OAI收割
JOURNAL OF ETHNOPHARMACOLOGY, 2021, 卷号: 270, 页码: 113872
作者:
Hou,Tao
;
Xu,Fangfang
;
Peng,Xingrong
;
Zhou,Han
;
Zhang,Xiuli
  |  
收藏
  |  
浏览/下载:68/0
  |  
提交时间:2022/04/02
Opioid receptors
Dynamic mass redistribution
Natural products
Antagonist
Selectivity
IDENTIFICATION
ANTAGONISTS
SUBSTANCES
NALOXEGOL
AGONISTS
SAFETY
MACA
Identification of SARS-CoV-2 entry inhibitors among already approved drugs
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 7
作者:
Yang, Li
;
Pei, Rong-juan
;
Li, Heng
;
Ma, Xin-na
;
Zhou, Yu
  |  
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2020/12/24
COVID-19
SARS-CoV-2
virus entry inhibitors
high throughput screening assay
approved drug library
histamine receptor antagonists
clemastine
Ligand-based pharmacophore model for the discovery of novel CXCR2 antagonists as anti-cancer metastatic agents
期刊论文
OAI收割
ROYAL SOCIETY OPEN SCIENCE, 2018, 卷号: 5, 期号: 7
作者:
Che, Jinxin
;
Wang, Zhilong
;
Sheng, Haichao
;
Huang, Feng
;
Dong, Xiaowu
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/01/08
pharmacophore model
CXCR2
antagonists
anti-cancer metastasis