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Targeting ST8SIA6-AS1 counteracts KRAS
G12C
inhibitor resistance through abolishing the reciprocal activation of PLK1/c-Myc signaling
期刊论文
OAI收割
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2023, 卷号: 12, 期号: 1, 页码: 22
作者:
Wang, Yafang
;
Yao, Mingyue
;
Li, Cheng
;
Yang, Kexin
;
Qin, Xiaolong
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2024/01/26
KRAS(G12C)
c-Myc
PLK1
LncRNA
ST8SIA6-AS1
Drug resistance
From bench to bedside: current development and emerging trend of KRAS-targeted therapy
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18
作者:
Chen, Yi
;
Liu, Qiu-pei
;
Xie, Hua
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2024/01/16
KRAS mutation
KRAS(G12C) inhibitor
Pan-KRAS inhibitor
SHP2 allosteric inhibitor
SOS1 inhibitor
combination therapy
Design, synthesis and biological evaluation of KRASG12C-PROTACs
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2023, 卷号: 78, 页码: 14
作者:
Zhang, Xiaoyi
;
Zhao, Tong
;
Sun, Minghao
;
Li, Pei
;
Lai, Mengzhen
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/04/10
KRASG12C
PROTAC
Covalent inhibitors
Structure-activity relationships (SARs)
Anticancer
In situ Raman spectroscopic measurement of the 13C/12C ratio in CO2: Experimental calibrations on the effects of fluid pressure, temperature and composition
期刊论文
OAI收割
Chemical Geology, 2023, 卷号: 615, 期号: 2023, 页码: 121201
作者:
Wenwen Lu
;
Xiaolin Wang
;
Qian Wan
;
Wenxuan Hu
;
I-Ming Chou
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/01/05
Raman spectroscopy
13C
12C ratio
CO2
Experimental calibration
T-P-x influences
Targeting PI3K alpha overcomes resistance to KRas(G12C) inhibitors mediated by activation of EGFR and/or IGF1R
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 12
作者:
Qi, Wei-liang
;
Li, Hui-yu
;
Wang, Yi
;
Xu, Lan
;
Deng, Jie-ting
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2023/04/10
AMG510
KRas(G12C)
PI3K
drug resistance
combination therapy
Safety and Efficacy of D-1553 in Patients with KRAS G12C Mutated Non-Small Cell Lung Cancer: A Phase 1 Trial
期刊论文
OAI收割
JOURNAL OF THORACIC ONCOLOGY, 2022, 卷号: 17
作者:
Lu, S.
;
Jian, H.
;
Zhang, Y.
;
Song, Z.
;
Zhao, Y.
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/12/23
Non-small cell lung cancer
KRAS G12C mutation
Small molecular inhibitor
Hepatic RACK1 deletion disturbs lipid and glucose homeostasis independently of insulin resistance
期刊论文
OAI收割
JOURNAL OF ENDOCRINOLOGY, 2022, 卷号: 254, 期号: 3, 页码: 151-165
作者:
Qin, Wanying
;
Zhang, Ting
;
Ge, Mingxia
;
Zhou, Huimin
;
Xu, Yuhui
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/04/30
RACK1
bile acid
glucose metabolism
insulin sensitivity
ENDOPLASMIC-RETICULUM STRESS
C-KINASE 1
HEPATOCELLULAR-CARCINOMA
STEROL 12-ALPHA-HYDROXYLASE
DOWN-REGULATION
ER STRESS
KAPPA-B
RECEPTOR
ACTIVATION
GROWTH
Studying the heavy-ion fusion reactions at stellar energies using Time Projection Chamber
期刊论文
OAI收割
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2021, 卷号: 1016, 页码: 12
作者:
Zhang, Z. C.
;
Wang, X. Y.
;
Pu, T. L.
;
Lu, C. G.
;
Zhang, N. T.
  |  
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2021/12/08
Heavy-ion fusion reactions
C-12+C-12
Time Projection Chamber
Gas Electron Multiplier
Tracking
Background
Nuclear matter distributions in the neutron-rich carbon isotopes C14-17 from intermediate-energy proton elastic scattering in inverse kinematics
期刊论文
OAI收割
NUCLEAR PHYSICS A, 2021, 卷号: 1008, 页码: 19
作者:
Dobrovolsky, A., V
;
Korolev, G. A.
;
Tang, S.
;
Alkhazov, G. D.
;
Colo, G.
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2022/01/07
C-12,C- 14,C- 15,C- 16,C- 17
Nuclear matter distribution
Nuclear matter radii
Proton-nucleus elastic scattering
Efficient interfacial charge transfer of 2D/2D porous carbon nitride/bismuth oxychloride step-scheme heterojunction for boosted solar-driven CO2 reduction
期刊论文
OAI收割
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2021, 卷号: 585
作者:
Huo, Yao
;
Zhang, Jinfeng
;
Wang, Zhongliao
;
Dai, Kai
;
Pan, Chengsi
  |  
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/03/15
Step-scheme heterojunction
Bi12O17Cl2
g-C3N4
Build-in electric field
Photocatalytic CO2 reduction