中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Design, synthesis and biological evaluation of novel pyrrolo[1,2-b]pyridazin-2(1
H
)-ones as selective PARP1 inhibitors for cancer therapy
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2026, 卷号: 307, 页码: 16
作者:
He, Qiaolin
;
He, Jing
;
Huan, Xiajuan
;
Song, Shanshan
;
Zhang, Xiaofei
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2026/04/01
PARP1 inhibitor
Subtype selectivity
Synthetic lethality
In vitro cytotoxicity
Dimeric alkenyl α-pyrones from Cryptocarya calcicola with their cytotoxicity
期刊论文
OAI收割
PHYTOCHEMISTRY, 2026, 卷号: 243, 页码: 7
作者:
Liu, Yu
;
Li, Wei
;
Su, Yu
;
Rao, Li
;
He, Qian
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2026/01/29
Cryptocarya calcicola
Lauraceae
alpha-pyrone dimers
X-ray crystallography
Biosynthetic pathway proposal
Cytotoxicity
Synthesis and characterization of selenourea-functionalized chitosan derivatives with enhanced antioxidant activity
期刊论文
OAI收割
CARBOHYDRATE RESEARCH, 2025, 卷号: 557, 页码: 12
作者:
Wang, Linqing
;
Han, Xiangru
;
Tian, Liguang
;
Yuan, Yuting
;
Zhang, Jingjing
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2025/10/13
Selenourea
Chitosan derivatives
Antioxidant activity
Cytotoxicity
Metabolic activation and cytotoxicity of bavachin mediated by CYP3A in mice
期刊论文
OAI收割
CHEMICO-BIOLOGICAL INTERACTIONS, 2025, 卷号: 419, 页码: 10
作者:
Ye, Tingmin
;
Tang, Chunping
;
Yang, Dandan
;
Zhang, Qing
;
Liao, Yufen
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/09/09
Bavachin
metabolic activation
Quinone
Cytotoxicity
Glutathione
Psoraleae fructus
Biotransformation of artemisinin by human intestinal fungi and cytotoxicity against breast cancer cells of its metabolites
期刊论文
OAI收割
PHYTOCHEMISTRY, 2025, 卷号: 238, 页码: 7
作者:
He, Xin
;
Wei, Xuemei
;
He, Zhong
;
Yao, Changliang
;
Nie, Min
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2025/08/20
Artemisinin
Biotransformation
Intestinal fungi
Cytotoxicity
New tetrahydrobenzocyclooctabenzofuranone and dibenzocyclooctadiene lignans from
Kadsura jaonica
期刊论文
OAI收割
FITOTERAPIA, 2025, 卷号: 186, 页码: 8
作者:
Su, Yu
;
Shen, Jingjing
;
Yao, Shuang
;
Miao, Lei
;
Zhang, Yu
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/12/04
Kadsura jaonica
Tetrahydrobenzocyclooctabenzofuranone
lignans
Dibenzocyclooctadiene lignans
Epoxy moiety
Cytotoxicity
Antioxidant activity
New Phenanthrene Derivatives and a Flavonoid Glycoside Dihexanoate From
Malpighia glabra
期刊论文
OAI收割
CHEMISTRY & BIODIVERSITY, 2025, 页码: 8
作者:
Fan, Enqi
;
Yao, Shuang
;
Zhang, Yu
;
Zhang, Yinan
;
Zhang, Chuan Rui
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/12/04
configuration determination
cytotoxicity
flavonoid glycoside
Malpighia glabra
phenanthrene derivatives
Synthesis, Characterization, Antioxidant Activity, Antibacterial Activity, and Cytotoxicity of Quaternized Inulin Derivatives Bearing Aromatic Amides
期刊论文
OAI收割
ANTIOXIDANTS, 2025, 卷号: 14, 期号: 9, 页码: 18
作者:
Chen, Yuan
;
Mi, Yingqi
;
Guo, Zhanyong
;
Zhang, Hongwu
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/11/03
antioxidant activity
antibacterial activity
cytotoxicity
Enhanced antibody-mediated cellular cytotoxicity of germline-like anti-HER2 antibodies through a point mutation in complementarity-determining regions
期刊论文
OAI收割
JOURNAL OF IMMUNOLOGY, 2025, 页码: 11
作者:
Zhou, Guangyu
;
Zhang, Yunsen
;
Gu, Yuheng
;
Cao, Bihui
;
Fan, Xin
  |  
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2025/06/23
affinity maturation
antibody-mediated cellular cytotoxicity
gremlin-like antibody
HER2
in silicon
Pentacyclic triterpenoids with cytotoxic activity from the stems of
Syzygium
jambos
(L.) Alston
期刊论文
OAI收割
FITOTERAPIA, 2025, 卷号: 181, 页码: 7
作者:
Liu, Zhilong
;
Huang, Yuepei
;
Chen, Jieting
;
Peng, Lihua
;
Qiao, Weilin
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2025/04/01
Syzygium jambos
Pentacyclic triterpenoids
Oleanane
Ursane
Cytotoxicity