机构

• 上海药物研究所 [27]
• 大连化学物理研究所 [1]
• 过程工程研究所 [1]
• 合肥物质科学研究院 [1]

采集方式

• OAI收割 [30]

内容类型

• 期刊论文 [29]
• 学位论文 [1]

发表日期

• 2025 [1]
• 2024 [1]
• 2023 [1]
• 2022 [4]
• 2021 [2]
• 2020 [3]
• 更多

学科主题

筛选

浏览/检索结果: 共30条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology 期刊论文  OAI收割 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2025, 卷号: 65, 页码: 191-213 作者:  Zhou, Qingtong;  Li, Guanyi;  Hang, Kaini;  Li, Jie;  Yang, Dehua   |  收藏  |  浏览/下载：8/0  |  提交时间：2025/04/01 overweight  glucagon-like peptide-1 receptor  unimolecular  polypharmacology  tirzepatide  retatrutide  metabolic diseases   Oral peptide therapeutics for diabetes treatment: State-of-the-art and future perspectives 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 5, 页码: 2006-2025 作者:  Ding, Bingwen;  Zhu, Zhu;  Guo, Cong;  Li, Jiaxin;  Gan, Yong   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/09/26 Oral peptides  Diabetes  Delivery platforms  Insulin  Glucagon-like peptide-1  Biodistribution  Biological barriers  Targeted delivery   Structural analysis of the dual agonism at GLP-1R and GCGR 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 33, 页码: 12 作者:  Li, Yang;  Zhou, Qingtong;  Dai, Antao;  Zhao, Fenghui;  Chang, Rulue   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/05/07 glucagon-like peptide-1 receptor  glucagon receptor  cryo-electron microscopy  dual agonism   Dimeric styrylpyrones with stimulating GLP-1 secretion activities from Alpinia kwangsiensis 期刊论文  OAI收割 TETRAHEDRON, 2022, 卷号: 120, 页码: 7 作者:  Wu, Meng-Zhen;  GongPan, Pian-Chou;  Dai, Meng -Yuan;  Sun, Peng;  Xiao, Chun-Fen   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/12/13 Glucagon-like peptide-1  Type 2 diabetes  Alpinia kwangsiensis  Dimeric styrylpyrones   Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13 作者:  Darbalaei, Sanaz;  Chang, Ru-lue;  Zhou, Qing-tong;  Chen, Yan;  Dai, An-tao   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/09/30 glucagon-like peptide-1 receptor  glucagon receptor  dual and triple agonist  cAMP  pERK1/2  unimolecular polypharmacology   Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists 期刊论文  OAI收割 PHARMACEUTICALS, 2022, 卷号: 15 作者:  Sun, Lei;  Zheng, Zhi-Ming;  Shao, Chang-Sheng;  Zhang, Zhi-Yong;  Li, Ming-Wei   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/12/22 glucagon-like peptide-1  GLP-1 receptor agonist  functional protein design  molecular dynamics simulation  long-acting antihyperglycemic   Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 20, 页码: 10 作者:  Cong, Zhaotong;  Zhou, Qingtong;  Li, Yang;  Chen, Li-Nan;  Zhang, Zi-Chen   |  收藏  |  浏览/下载：42/0  |  提交时间：2022/09/30 glucagon-like peptide-1 receptor  type 2 diabetes mellitus  cryoelectron microscopy  peptidomimetic agonism   Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 8 作者:  Wang, Yu-zhe;  Yang, De-hua;  Wang, Ming-wei   |  收藏  |  浏览/下载：33/0  |  提交时间：2021/11/04 glucagon-like peptide-1 receptor  glucose-dependent insulinotropic peptide receptor  peptide 19  LY3298176  heteromerization  type 2 diabetes   Secretion of glucagon-like peptide-1 induced by Cynanchum pregnane derivatives: Preliminary hypotheses regarding key structural elements 期刊论文  OAI收割 PHYTOCHEMISTRY LETTERS, 2021, 卷号: 41, 页码: 88-91 作者:  Huguet, Clement;  Real, Eleonore;  Zhao, Wei-Min;  Urbain, Aurelie   |  收藏  |  浏览/下载：27/0  |  提交时间：2021/11/04 Pregnanes  Cynanchum  Apocynaceae  Diabetes  Glucagon-like peptide-1  Structure-activity relationships   Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16 作者:  Darbalaei, Sanaz;  Yuliantie, Elita;  Dai, Antao;  Chang, Rulue;  Zhao, Peishen   |  收藏  |  浏览/下载：35/0  |  提交时间：2020/12/21 G protein-coupled receptor  Glucagon-like peptide-1 receptor  Glucagon receptor  Biased agonism  Unimolecular dual agonist