机构

• 上海药物研究所 [19]
• 中国科学院大学 [2]
• 上海生物化学与细胞生... [1]

采集方式

• OAI收割 [20]
• iSwitch采集 [2]

内容类型

• 期刊论文 [22]

发表日期

• 2025 [1]
• 2023 [2]
• 2022 [1]
• 2021 [2]
• 2020 [1]
• 2019 [1]
• 更多

学科主题

• Hematology... [1]

筛选

浏览/检索结果: 共22条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Hemodynamic and Pharmacokinetic Interactions of TPN171 with Alcohol in Healthy Male Subjects 期刊论文  OAI收割 CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2025, 卷号: 18, 期号: 2, 页码: 8 作者:  Cheng, Jie;  Qian, Hongjie;  Wang, Yu;  Liang, Liyu   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/04/01 alcohol  healthy subjects  hemodynamics  PDE5 inhibitor  pharmacokinetics  TPN171   Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14 作者:  Liu, Jiayuan;  Zhang, Xianglei;  Chen, Guofeng;  Shao, Qiang   |  收藏  |  浏览/下载：41/0  |  提交时间：2024/01/16 Phosphodiesterase-4 (PDE4)  PDE5  Inhibitor  Drug repurposing  Crystal structure  Structure -guided optimization   Pharmacokinetics,mass balance,and metabolism of 14C TPN171,a novel PDE5 inhibitor,in humans for the treatment of pulmonary arterial hypertension 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 1, 页码: 221 作者:  He Yifei;  Liu Yin;  Yu Jinghua;  Cheng Huan;  Odilov Abdullajon   |  收藏  |  浏览/下载：26/0  |  提交时间：2023/05/22 TPN171  14CTPN171  PDE5 inhibitor  pulmonary arterial hypertension  healthy volunteers  pharmacokinetics  metabolite identification  mass balance   Pharmacokinetics, mass balance, and metabolism of [C-14]TPN171, a novel PDE5 inhibitor, in humans for the treatment of pulmonary arterial hypertension 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13 作者:  He, Yi-fei;  Liu, Yin;  Yu, Jing-hua;  Cheng, Huan;  Odilov, Abdullajon   |  收藏  |  浏览/下载：50/0  |  提交时间：2022/08/16 TPN171  [C-14]TPN171  PDE5 inhibitor  pulmonary arterial hypertension  healthy volunteers  pharmacokinetics  metabolite identification  mass balance   Facile and Cost-Effective Route for the Synthesis of Simmerafil 期刊论文  OAI收割 ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 11, 页码: 2432-2437 作者:  Odilov, Abdullajon;  Liu, Yin;  Hu, Tianwen;  Jiang, Xiangrui;  Suo, Jin   |  收藏  |  浏览/下载：51/0  |  提交时间：2022/01/18 simmerafil  PDE5 inhibitor  salicylamide  synthesis   A Phase I Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of TPN171H, a Novel Phosphodiesterase Type 5 Inhibitor, in Healthy Subjects 期刊论文  OAI收割 DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15, 页码: 2947-2959 作者:  Qian, Hongjie;  Chen, Qian;  Lang, Liyu;  Zou, Yang;  Pu, Huahua   |  收藏  |  浏览/下载：31/0  |  提交时间：2021/08/17 TPN171H  PDE5 inhibitor  safety  pharmacokinetics  food effect  healthy subjects   Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9 作者:  Tian, Qian-qian;  Zhu, Yun-ting;  Diao, Xing-xing;  Zhang, Xiang-lei   |  收藏  |  浏览/下载：44/0  |  提交时间：2020/12/24 PDE5 inhibitor  TPN729  M3  species difference  pharmacokinetics  metabolite identification   Fragment-based drug discovery of triazole inhibitors to block PDE delta-RAS protein-protein interaction 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 163, 页码: 597-609 作者:  Chen, Danqi;  Chen, Yuehong;  Lian, Fulin;  Chen, Liu;  Li, Yanlian   |  收藏  |  浏览/下载：28/0  |  提交时间：2020/07/01 PDE delta-RAS  Fragment-based  Inhibitor  Protein-protein interaction   Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease 期刊论文  OAI收割 ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345 作者:  Mao, Fei;  Wang, Huan;  Ni, Wei;  Zheng, Xinyu;  Wang, Manjiong   |  收藏  |  浏览/下载：64/0  |  提交时间：2019/01/08 Alzheimer's disease  drug repositioning  dual-target inhibitor  AChE inhibition  PDE5 inhibition   Design and optimization of purine derivatives as in vivo active PDE10A inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2017, 卷号: 25, 期号: 13, 页码: 3315-3329 作者:  Chen, Liu;  Chen, Danqi;  Tang, Le;  Ren, Jing;  Chen, Jiaojiao   |  收藏  |  浏览/下载：50/0  |  提交时间：2019/01/08 Phosphodiesterase  PDE10A  Purine  Inhibitor  Anti-psychotic