中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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期刊论文 [181]
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The Tyrosine Kinase Inhibitor Bafetinib Inhibits PAR2-induced Activation of TRPV4 In Vitro and Pain In Vivo1
期刊论文
OAI收割
出版物, 2111, 页码: 1-44
作者:
1M S Grace
;
T Lieu
;
B Darby
;
F C Abogadie
;
N Veldhuis N W Bunnett
;
P McIntyre
  |  
收藏
  |  
浏览/下载:244/0
  |  
提交时间:2017/07/24
Transient Receptor Potential Ion Channel
Trpv4
Protease Activated Receptor
Par2
Pain
Tyrosine Kinase
Bafetinib
Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1318, 页码: 13
作者:
Tang, Mingze
;
Zhou, Xuan
;
Shen, Qianqian
;
Fang, Chen
;
Peng, Xia
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/08/22
Receptor -interacting protein kinase 1
Histone deacetylases
Inhibitor
Molecular dynamics (MD) simulation
ADMET analysis
Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors
期刊论文
OAI收割
ARCHIV DER PHARMAZIE, 2024, 页码: 16
作者:
An, Yuxiang
;
Peng, Xia
;
Wang, Tianchen
;
Liu, Kaiyuan
;
Feng, Dazhi
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/12/25
inhibitor
pharmacokinetic study
pyridazin-4-one
receptor-interacting protein kinase 1
selectivity
Discovery and optimization of 3-(indolin-5-yloxy)pyridin-2-amine derivatives as potent necroptosis inhibitors
期刊论文
OAI收割
ARCHIV DER PHARMAZIE, 2024, 页码: 21
作者:
Lan, Yaohan
;
Ji, Yinchun
;
Peng, Xia
;
Duan, Wenhu
;
Geng, Meiyu
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/08/22
autoimmune disease
necroptosis inhibitor
pharmacokinetic profile
receptor interacting protein kinase 1 (RIPK1)
structural optimization
Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 16
作者:
Chen, Yun
;
Ning, Yi
;
Chen, Zhiwei
;
Xue, Yaping
;
Wu, Qingyun
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/10/17
Apoptosis
Diffuse large B-Cell lymphoma
Interleukin-1 receptor associated kinase 4
Structure-based drug design
2
3-Dihydrobenzofuran
Baseline anemia predicts a poor prognosis in patients with non-small cell lung cancer with epidermal growth factor receptor mutations: a retrospective study
期刊论文
OAI收割
BMC PULMONARY MEDICINE, 2022, 卷号: 22
作者:
Wei, Jingwen
;
Xiang, Jing
;
Hao, Yue
;
Si, Jinfei
;
Wang, Wenxian
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2022/12/22
Anemia
Epidermal growth factor receptor
Epidermal growth factor receptor tyrosine kinase inhibitors
Non-small cell lung cancer
Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China
期刊论文
OAI收割
THORACIC CANCER, 2022
作者:
Xu, Chunwei
;
Si, Lu
;
Wang, Wenxian
;
Li, Ziming
;
Song, Zhengbo
  |  
收藏
  |  
浏览/下载:66/0
  |  
提交时间:2022/12/22
fusion
precision medicine
solid tumor
targeted therapy
tyrosine receptor kinase
原肌球蛋白受体激酶(TRK)抑制剂的研究进展
期刊论文
OAI收割
有机化学, 2022, 卷号: 42, 期号: 7, 页码: 2055-2069
作者:
杨竣喆
;
许子超
;
李淳朴
;
程远征
;
柳红
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/03/21
tropomyosin receptor kinase
anticancer
inhibitor
Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1 alpha Pathway
期刊论文
OAI收割
PHARMACEUTICALS, 2022, 卷号: 15, 期号: 4, 页码: 18
作者:
Chen, Dandan
;
Duan, Yanan
;
Yu, Shuxiang
;
Zhang, Xinwen
;
Li, Ni
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/06/15
obesity
rutaecarpine
adipocytes
thermogenesis
peroxisome-proliferator-activated receptor gamma co-activator-1 alpha
AMP-activated protein kinase
browning
Discovery of 4-cyclopropyl-3-(2-((1-cyclopropyl-1H-pyrazol-4-yl) amino) quinazolin-6-yl)-N-(3-(trifluoromethyl) phenyl) benzamides as potent discoidin domain receptor inhibitors for the treatment of idiopathic pulmonary fibrosis
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 4, 页码: 1943-1962
作者:
Wang, Qi
;
Tang, Bixi
;
Sun, Dandan
;
Dong, Ying
;
Ji, Yinchun
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2022/08/16
Idiopathic pulmonary fibrosis
Discoidin domain receptor
Kinase
Inhibitor
Docking