中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [25]
昆明植物研究所 [17]
过程工程研究所 [12]
烟台海岸带研究所 [4]
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期刊论文 [84]
CNKI期刊论文 [1]
会议论文 [1]
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2024 [5]
2023 [6]
2022 [7]
2021 [8]
2020 [4]
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Design, synthesis and activity evaluation of novel quinazolinone compounds as TRPC5 inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 155, 页码: 20
作者:
Bai, Longhui
;
Xiang, Yu
;
Shen, Meiling
;
Han, Yujun
;
Li, Penghua
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/04/01
TRPC5
Inhibitors
Structural modifications and optimizing
Synthesis
Quinazolinone compounds
Activity evaluation
Design, synthesis and biological evaluation of Alisol B derivatives for potential treatment of non-alcoholic steatohepatitis
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 155, 页码: 15
作者:
Yu, Nai-Rong
;
Huang, Suling
;
Deng, Zhen-Tao
;
Wang, Jiayue
;
Shen, Yu
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/04/01
Non-alcoholic steatohepatitis (NASH)
Alisol B
Structural modification
Structure-activity relationship
HFD+CCl4-induced NASH mice model
Cytotoxic diterpenoids from
Croton
kongensis
inhibiting tumor proliferation and migration
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 152, 页码: 15
作者:
Zhu, Qiong
;
Li, Ying
;
Wang, Chenglei
;
Yu, Jinhai
;
Yue, Jianmin
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/10/21
Croton kongensis
ent-Kauranes
Structural elucidation
Structure-activity relationship
Anticancer mechanism
Intriguing steroid glycosides for cancer therapy by suppressing the DNA damage response and mTOR/S6K signaling pathways
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 151, 页码: 14
作者:
An, Pei-Pei
;
Huang, Hui
;
Ru, Su-Jie
;
Gao, Yuan
;
Ren, Yu-Hao
  |  
收藏
  |  
浏览/下载:91/0
  |  
提交时间:2024/09/26
Strophanthus divaricatus
Steroid glycosides
Structural elucidation
Structure-activity relationship
Anticancer mechanism
Discovery and characterization of novel potent non-covalent small molecule inhibitors targeting papain-like protease from SARS-CoV-2
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 7, 页码: 3286-3290
作者:
Zheng, Miao
;
Feng, Bo
;
Zhang, Yumin
;
Liu, Xin
;
Zhao, Na
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/08/22
Non-covalent PLpro inhibitors
Antiviral activity
Structural-based drug design
Imidazo[4,5-b]pyridine scaffold
Highly Aromatic Norditerpenoid Heterodimers and Monomers from
Trigonostemon fragilis
期刊论文
OAI收割
ENGINEERING, 2024, 卷号: 38, 页码: 144-154
作者:
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/10/21
Norditerpenoid heterodimer
Trigonostemon fragilis
Euphorbiaceae
Trigofragiloid
Structural revision
Adenosine triphosphate-citrate lyase (ACLY)
inhibitory activity
A novel approach to exploit Small-Molecule glucagon-like Peptide-1 receptor agonists with high potency
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 107, 页码: 19
作者:
Wang, Xiaoyan
;
Yun, Ying
;
Chen, Lili
;
Guo, Shimeng
;
Niu, Buying
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/07/12
Diabetes
GLP-1 receptor
Agonist
Structural optimization
Water molecule replacement
Structure activity relationship
Docking simulation
Oxygenated Cembrane Diterpenes from the South China Sea Soft Coral Sinularia tumulosa
期刊论文
OAI收割
CHEMISTRY & BIODIVERSITY, 2023, 页码: 5
作者:
Zhu, Sheng-Hui
;
Yu, Dan-Dan
;
Su, Ming-Zhi
;
Luo, Hui
;
Yao, Li-Gong
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2023/10/17
antibacterial activity
cembrane diterpene
Sinularia tumulosa
soft coral
structural elucidation
Structural Characterization and Anticoagulant Activities of a Keratan Sulfate-like Polysaccharide from the Sea Cucumber Holothuria fuscopunctata
期刊论文
OAI收割
MARINE DRUGS, 2023, 卷号: 21, 期号: 12, 页码: 632
作者:
Chen,Ru
;
Wang,Weili
;
Yin,Ronghua
;
Pan,Ying
;
Xu,Chen
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/05/09
aminoglycan
structural features
keratan sulfate
depolymerization
oligosaccharides
anticoagulant activity
INTRINSIC-FACTOR XASE
GLYCOSAMINOGLYCAN
OLIGOSACCHARIDES
DEPOLYMERIZATION
ELUCIDATION
DERIVATIVES
HEPARIN
Discovery of diverse sesquiterpenoids from Magnolia grandiflora with cytotoxic activities by inducing cell apoptosis
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 139, 页码: 106707
作者:
Xu,Shuangyu
;
Tang,Yunyan
;
Li,Yanan
;
Yang,Jue
;
Gu,Wei
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/07/22
Magnolia grandiflora
Sesquiterpenoids
Isolation and structural modification
Cytotoxic activity
Apoptosis
LACTONES
DERIVATIVES
LEAVES
AGENTS