机构

• 上海药物研究所 [12]
• 金属研究所 [11]
• 过程工程研究所 [2]
• 长春应用化学研究所 [1]

采集方式

• OAI收割 [26]

内容类型

• 期刊论文 [26]

发表日期

• 2024 [1]
• 2021 [2]
• 2020 [1]
• 2018 [2]
• 2017 [1]
• 2016 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共26条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Discovery of novel small molecules targeting hepatitis B virus core protein from marine natural products with HiBiT-based high-throughput screening 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 11, 页码: 4914-4933 作者:  Huang, Chao;  Jin, Yang;  Fu, Panpan;  Hu, Kongying;  Wang, Mengxue   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/01/06 Anti-HBV  HBV core protein  Core protein assembly modulators  Marine natural products  HiBiT  Lead compound  Naamidine J derivative  Bioactivity-driven synthesis   Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 13 作者:  Zhou, Yu;  Li, Xiaoguang;  Chen, Kerong;  Ba, Qian;  Zhang, Xu   |  收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24 Structural optimization  Lead compound  Artemisinin derivatives  Cancer   Structural optimization and biological evaluation for novel artemisinin derivatives against liver and ovarian cancers 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 211, 页码: 13 作者:  Zhou, Yu;  Li, Xiaoguang;  Chen, Kerong;  Ba, Qian;  Zhang, Xu   |  收藏  |  浏览/下载：31/0  |  提交时间：2021/06/11 Structural optimization  Lead compound  Artemisinin derivatives  Cancer   先导化合物结构优化策略七肽类分子结构修饰与改造 期刊论文  OAI收割 药学学报, 2020, 卷号: 55, 期号: 3, 页码: 427 作者:  彭晶晶;  王江;  戴文豪;  谢雄;  柳红   |  收藏  |  浏览/下载：55/0  |  提交时间：2020/07/01 peptide  structure optimization  drug design  lead compound  多肽  结构改造  药物设计  先导化合物   HS218 as an FXR antagonist suppresses gluconeogenesis by inhibiting FXR binding to PGC-1 alpha promoter 期刊论文  OAI收割 METABOLISM-CLINICAL AND EXPERIMENTAL, 2018, 卷号: 85, 页码: 126-138 作者:  Xu, Xin;  Shi, Xiaofan;  Chen, Yidi;  Zhou, Tingting;  Wang, Jiaying   |  收藏  |  浏览/下载：45/0  |  提交时间：2020/07/01 T2DM  Gluconeogenesis  FXR antagonist  PGC-1 alpha  Drug lead compound   Lead compound optimization strategy (6) - improving the plasma stability 期刊论文  OAI收割 Acta Pharmaceutica Sinica, 2018, 卷号: 53, 期号: 2, 页码: 192-201 作者:  Wu Xiaowei;  Wang Jiang;  Liu Hong   |  收藏  |  浏览/下载：48/0  |  提交时间：2019/01/08 plasma stability  structural modification  lead compound  bioisosterism   Aglaiabbrevins A-D, New Prenylated Bibenzyls from the Leaves of Aglaia abbreviata with Potent PTP1B Inhibitory Activity 期刊论文  OAI收割 CHEMICAL & PHARMACEUTICAL BULLETIN, 2017, 卷号: 65, 期号: 3, 页码: 295-299 作者:  Sun, Pan;  Jiang, Chang-Sheng;  Zhang, Yi;  Liu, Ai -Hong;  Liang, Tong -Jun   |  收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 Aglaia abbreviata  prenylated bibenzyl  aglaiabbrevin  protein tyrosine phosphatase-1B inhibitor  potential lead compound   Lead compound optimization strategy (5) - reducing the hERG cardiac toxicity in drug development 期刊论文  OAI收割 Acta Pharmaceutica Sinica, 2016, 卷号: 51, 期号: 10, 页码: 1530-1539 作者:  Zhou Shengbin;  Wang Jiang;  Liu Hong   |  收藏  |  浏览/下载：54/0  |  提交时间：2019/01/08 hERG  lead compound optimization  lipophilicity  basicity  conformation restriction  cardiac toxicity   Emergence of Chinese Drug Discovery Research: Impact of Hit and Lead Identification 期刊论文  OAI收割 JOURNAL OF BIOMOLECULAR SCREENING, 2015, 卷号: 20, 期号: 3, 页码: 318-329 作者:  Zhou, Caihong;  Zhou, Yan;  Wang, Jia;  Zhu, Yue;  Deng, Jiejie   |  收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 review  drug discovery  hit identification  lead generation  compound library   Effect of doping Al on the liquid oxidation of Sn-Bi-Zn solder 期刊论文  OAI收割 Journal of Materials Science-Materials in Electronics, 2014, 卷号: 25, 期号: 5, 页码: 2297-2304 X. J. Wang; Q. S. Zhu; B. Liu; N. Liu; F. J. Wang 收藏  |  浏览/下载：27/0  |  提交时间：2014/07/03 lead-free solder  intermetallic compound growth  corrosion behavior  mechanical-properties  cu substrate  alloy  microstructure  reduction  aluminum  vacuum