中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [7]
化学研究所 [1]
昆明植物研究所 [1]
采集方式
OAI收割 [9]
内容类型
期刊论文 [9]
发表日期
2023 [1]
2021 [2]
2020 [1]
2017 [1]
2013 [1]
2012 [1]
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学科主题
Chemistry,... [1]
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Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 247, 页码: 115034
作者:
Song, Shukai
;
Tang, Haotian
;
Ran, Ting
;
Fang, Feng
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/03/27
SyntaLinker
Generative modelling
TBK1 inhibitor
pyrrolo[2
3-d]pyrimidine
Structure-activity relationship
Temperature-Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2-a]indole Derivatives via Iridium Catalysis
期刊论文
OAI收割
ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 页码: 14
作者:
Liu, Siyu
;
Mao, Hui
;
Qiao, Jin
;
Zhang, Xiaoning
;
Lu, Yangbin
  |  
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2021/11/04
Iridium
C-H activation
[3+2] annulation
Tetrasubstituted alkene
pyrrolo[1,2-a]indole
Identification of methyl (5-(6-((4-(methylsulfonyl)piperazin-1-yl)methyl)-4-morpholinopyrrolo[2,1-f][1,2,4]triazin-2-yl)-4-(trifluoromethyl)pyridin-2-yl)carbamate (CYH33) as an orally bioavailable, highly potent, PI3K alpha inhibitor for the treatment of advanced solid tumors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 209, 页码: 10
作者:
Xiang, Hao-Yue
;
Wang, Xiang
;
Chen, Yan-Hong
;
Zhang, Xi
;
Tan, Cun
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/05/24
PI3K
Pyrrolo[2,1-f][1,2,4]triazine
Anti-cancer
Target therapy
Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo [2,1-f] [1,2,4] triazine derivatives
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 12, 页码: 4
作者:
Xiang, Hao-Yue
;
Chen, Yan-Hong
;
Wang, Yi
;
Zhang, Xi
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2020/07/01
Antiproliferative
Cancer
Therapy
PI3K inhibitors
Pyrrolo [2,1-f][1,2,4] triazine
Kinase
Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 8, 期号: 8, 页码: 875-880
作者:
Yang, Chengbin
;
Zhang, Xi
;
Wang, Yi
;
Yang, Yongtai
;
Liu, Xiaofeng
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
PI3K
PI3K/mTOR
oncology
1H-pyrrolo[2,3-b] pyridine
cancer therapy
A tandem copper (II)-promoted synthesis of 2-substituted pyrrolo [2,1-f][1,2,4] triazin-4(3H)-ones
期刊论文
OAI收割
TETRAHEDRON, 2013, 卷号: 69, 期号: 13, 页码: 2714-2719
作者:
Chen, Yanhong
;
Xiang, Haoyue
;
Tan, Cun
;
Xie, Yuyuan
;
Yang, Chunhao
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Tandem annulation
Cupric chloride
1-Amino-1H-pyrrole-2-amides
Privileged structure
Pyrrolo[2,1-f][1,2,4]triazin-4(3H)-ones
Synthesis and characterization of thieno[3,4-c]pyrrole-4,6-dione and pyrrolo [3,4-c]pyrrole-1,4-dione-based random polymers for photovoltaic applications
期刊论文
OAI收割
POLYMER, 2012, 卷号: 53, 期号: 20, 页码: 4407-4412
作者:
Zhang, Guobing
;
Fu, Yingying
;
Qiu, Longzhen
;
Xie, Zhiyuan
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/04/09
Random Polymer
Thieno[3
Pyrrolo[3
4-c]Pyrrole-4
4-c]Pyrrole-1
6-dione
4-dione
Molecular docking-based 3D-QSAR studies of pyrrolo[3,4-c]pyrazole derivatives as Aurora-A inhibitors
期刊论文
OAI收割
MOLECULAR SIMULATION, 2011, 卷号: 37, 期号: 1, 页码: 31-42
He, G.
;
Qiu, M. H.
;
Li, R.
;
Song, X. R.
;
Zheng, X.
;
Shi, J. Y.
;
Xu, G. B.
;
Han, J.
;
Yu, L. T.
;
Yang, S. Y.
;
Chen, L. J.
;
Wei, Y. Q.
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2012/10/12
pyrrolo[3
4-c]pyrazole derivatives
3D-QSAR
molecular docking
CoMFA
CoMSIA
KINASE INHIBITORS
PROTEIN-KINASE
PHARMACOPHORE MODEL
SIMILARITY INDEXES
ANALYSIS COMSIA
POTENT
IDENTIFICATION
BINDING
PROFILE
COMFA
Gold(I)-Catalyzed One-Pot Tandem Coupling/Cyclization: An Efficient Synthesis of Pyrrolo-/Pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones
期刊论文
OAI收割
ADVANCED SYNTHESIS & CATALYSIS, 2010, 卷号: 352, 期号: 2-3, 页码: 373-378
作者:
Zhou, Yu
;
Zhai, Yun
;
Ji, Xun
;
Liu, Guannan
;
Feng, Enguang
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
alkynes
gold
pyrrolo-/pyrido[2,1-b]benzo[d][1,3]oxazin-1-ones
tandem reactions