中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [56]
昆明植物研究所 [8]
化学研究所 [7]
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期刊论文 [120]
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The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches
期刊论文
OAI收割
BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2023, 卷号: 23, 期号: 1, 页码: 17
作者:
Sultan, Rida
;
Ahmed, Abrar
;
Wei, Li
;
Saeed, Hamid
;
Islam, Muhammad
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/19
CDK2
ER+ Breast cancer
Molecular Docking
MM-GBSA
Molecular Dynamic Simulations
MTT assay
Moringa oleifera
Phytoconstituents
Chlorogenic acid
Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 7069
作者:
Zhou, Lin-Lin
;
Zhang, Tao
;
Xue, Yun
;
Yue, Chuan
;
Pan, Yihui
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2024/03/27
Discovery, Structure-Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein-Protein Interactions between AF9/ENL and AF4 or DOT1L
期刊论文
OAI收割
CANCERS, 2023, 卷号: 15, 期号: 21, 页码: 28
作者:
Li, Xin
;
Wu, Xiaowei
;
Nie, Shenyou
;
Zhao, Jidong
;
Yao, Yuan
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2023/12/19
MLL-rearranged leukemia
super elongation complexes
small-molecule inhibitor
protein-protein interaction
cancer therapeutics
Investigation of targets and anticancer mechanisms of covalently acting natural products by functional proteomics
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 8, 页码: 1701-1711
作者:
Zhao, Wen-si
;
Chen, Kai-feng
;
Liu, Man
;
Jia, Xing-long
;
Huang, Yu-qi
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/03/27
natural products
proteomics
ABPP
eriocalyxin B
parthenolide
Combined inhibition of PARP and ATR synergistically potentiates the antitumor activity of HER2-targeting antibody-drug conjugate in HER2-positive cancers
期刊论文
OAI收割
AMERICAN JOURNAL OF CANCER RESEARCH, 2023, 卷号: 13, 期号: 1, 页码: 161-+
作者:
Li, Yongpeng
;
Li, Lin
;
Fu, Haoyu
;
Yao, Qing
;
Wang, Lei
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/17
Antibody-drug conjugate
DS-8201
PARP
ATR
synergy
DNA damage
Design and development of a novel series of oral bivalent BET inhibitors with potent anticancer activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 239, 页码: 13
作者:
Luo, Menglan
;
Wu, Qian
;
Yang, Yueyue
;
Sun, Lin
;
Huan, Xiajuan
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/08/30
BET inhibitor
BRD4
Bivalent inhibitor
Anticancer
Integrating UPLC-HR-MS/MS, Network Pharmacology, and Experimental Validation to Uncover the Mechanisms of Jin?gan Capsules against Breast Cancer br
期刊论文
OAI收割
ACS OMEGA, 2022, 卷号: 7, 期号: 32, 页码: 28003-28015
作者:
Qiu, Jianfei
;
Zhang, Zhiyin
;
Hu, Anling
;
Zhao, Peng
;
Wei, Xuenai
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/09/30
Integrating UPLC-HR-MS/MS, Network Pharmacology, and Experimental Validation to Uncover the Mechanisms of Jin'gan Capsules against Breast Cancer
期刊论文
OAI收割
ACS OMEGA, 2022, 页码: 13
作者:
Qiu, Jianfei
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2022/09/30
Controlling the Shrinkage of 3D Hot Spot Droplets as a Microreactor for Quantitative SERS Detection of Anticancer Drugs in Serum Using a Handheld Raman Spectrometer
期刊论文
OAI收割
ANALYTICAL CHEMISTRY, 2022, 卷号: 94
作者:
Zhou, Guoliang
;
Li, Pan
;
Ge, Meihong
;
Wang, Junping
;
Chen, Siyu
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2022/05/16
Efficient Synthesis and Biological Evaluation of 6-Trifluoroethoxy Functionalized Pteridine Derivatives as EGFR Inhibitors
期刊论文
OAI收割
MEDICINAL CHEMISTRY, 2022, 卷号: 18, 期号: 3, 页码: 353-363
作者:
Lin, Jin
;
Zhang, Zemin
;
Lin, Xiongqiang
;
Chen, Zhendong
;
Luc, Tian
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2022/06/15
Pteridine
derivatives
EGFR
inhibitor
2,2,2-trifluoroethoxy
antitumor activity