机构

• 上海药物研究所 [377]
• 化学研究所 [148]
• 上海硅酸盐研究所 [82]
• 昆明植物研究所 [70]
• 深圳先进技术研究院 [68]
• 金属研究所 [62]
• 更多

采集方式

• OAI收割 [1444]
• iSwitch采集 [52]

内容类型

• 期刊论文 [1423]
• 学位论文 [40]
• 会议论文 [32]
• 专利 [1]

发表日期

• 2023 [54]
• 2022 [77]
• 2021 [90]
• 2020 [82]
• 2019 [111]
• 2018 [148]
• 更多

学科主题

• Biochemis... [28]
• Chemistry [18]
• Cell Biol... [15]
• 生命有机化学 [15]
• Pharmacol... [13]
• Chemistry... [10]
• 更多

筛选

浏览/检索结果: 共1496条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Construction of a myoglobin scaffold-based biocatalyst for the biodegradation of sulfadiazine and sulfathiazole 期刊论文  OAI收割 JOURNAL OF HAZARDOUS MATERIALS, 2024, 卷号: 465, 页码: 10 作者:  Zhang, Weikang   |  收藏  |  浏览/下载：13/0  |  提交时间：2024/01/26 Sulfonamides  Myoglobin  Biocatalysis  Biodegradation  Directed evolution   Meta-MolNet: A Cross-Domain Benchmark for Few Examples Drug Discovery 期刊论文  OAI收割 IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS, 2024, 页码: 15 作者:  Lv, Qiujie;  Chen, Guanxing;  Yang, Ziduo;  Zhong, Weihe;  Chen, Calvin Yu-Chian   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/04/09 Benchmark platform  cross-domain meta-learning  drug discovery  few examples  Meta-MolNet  molecular property   Development of Potent MALT1 Inhibitors Featuring a Novel "2-Thioxo-2,3-dihydrothiazolo[4,5-d]pyrimidin-7(6H)-one" Scaffold for the Treatment of B Cell Lymphoma 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 4, 页码: 2884-2906 作者:  Liang, Xuewu;  Yu, Haolan;  Liang, Renwen;  Feng, Zhuanghui;  Saidahmatov, Abdusaid   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/04/09 Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17 作者:  Lan, Yaohan;  Peng, Xia;  Ji, Yinchun;  Su, Yi;  Duan, Wenhu   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/02/27 AXL inhibitor  In vivo antitumor efficacy  6-Naphthyridin-4-one derivatives  Scaffold hopping  Structure-based drug design   A chromosome-level genome assembly of a deep-sea symbiotic Aplacophora mollusc Chaetoderma sp. 期刊论文  OAI收割 SCIENTIFIC DATA, 2024, 卷号: 11, 期号: 1, 页码: 9 作者:  Wang, Yue;  Wang, Minxiao;  Li, Jie;  Zhang, Junlong;  Zhang, Linlin   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/04/07 Synthesis of 2-amino-9H-chromeno[2,3-d]thiazol-9-ones with anti-inflammatory activity via cascade reactions of 2-amino-3 iodochromones with amines and carbon disulfide 期刊论文  OAI收割 RSC ADVANCES, 2024, 卷号: 14, 期号: 5, 页码: 3158-3162 作者:  Tan, Jiangtao;  He, Yifan;  Lin, Yu;  Zhong, Yuanchen;  He, Shijun   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/02/27 Discovery, Optimization, and Evaluation of Novel Pyridin-2(1H)-one Analogues as Potent TRK Inhibitors for Cancer Treatment 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1168-1183 作者:  Xu, Zichao;  Peng, Xia;  Zhang, Renjie;  Ji, Yinchun;  You, Mengke   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/02/27 Discovery of JN122, a Spiroindoline-Containing Molecule that Inhibits MDM2/p53 Protein-Protein Interaction and Exerts Robust In Vivo Antitumor Efficacy 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 24, 页码: 16991-17025 作者:  Cheng, Jing;  Yan, Ziqin;  Jiang, Kailong;  Liu, Chen;  Xu, Dehua   |  收藏  |  浏览/下载：4/0  |  提交时间：2024/02/19 Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933 作者:  Fang, Feifei;  Dai, Yang;  Wang, Hao;  Ji, Yinchun;  Liang, Xuewu   |  收藏  |  浏览/下载：7/0  |  提交时间：2024/01/26 derivatives  Antitumor drug development  Potential AXL inhibitor  Antitumor activity  Structure-based drug design  Fused-pyrazolone carboxamide   Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 22, 页码: 15269-15287 作者:  Hu, Linghao;  Li, Huiyun;  Qin, Junlin;  Yang, Dan;  Liu, Jieming   |  收藏  |  浏览/下载：19/0  |  提交时间：2024/02/27