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浏览/检索结果: 共713条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10 作者:  Chen, Guofeng;  Xie, Hang;  Liu, Jiayuan;  Shao, Qiang;  Li, Minjun   |  收藏  |  浏览/下载：8/0  |  提交时间：2024/01/26 Methyl substitution  Selectivity  FABP4 inhibitor  Anti-inflammation  Metabolic stability   Design, Synthesis, and Biological Evaluation of Potent and Selective PROTAC Degraders of Oncogenic KRASG12D 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 2, 页码: 1147-1167 作者:  Zhou, Chuan;  Fan, Zisheng;  Gu, Yuejiao;  Ge, Zhiming;  Tao, Zhaofan   |  收藏  |  浏览/下载：10/0  |  提交时间：2024/02/27 Unveiling the potential of machine learning in schizophrenia diagnosis: A meta-analytic study of task-based neuroimaging data 期刊论文  OAI收割 PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2023, 页码: 12 作者:  Wang, Xuan;  Yan, Chao;  Yang, Peng-yuan;  Xia, Zheng;  Cai, Xin-lu   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/01/22 attention  machine learning  meta-analysis  schizophrenia  task-based fMRI   A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects 期刊论文  OAI收割 EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9 作者:  Yang, Xin-Mei   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/12/11 COVID-19  Simnotrelvir  Safety  Pharmacokinetics  Healthy subjects   Discovery of PVD-06 as a Subtype-Selective and Efficient PTPN2 Degrader 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 22, 页码: 15269-15287 作者:     |  收藏  |  浏览/下载：20/0  |  提交时间：2024/02/27 The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 12 作者:  Cui, Shi-hao;  Suo, Na;  Yang, Ying;  Wu, Xuan;  Guo, Shi-meng   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/12/11 oligodendrocyte  oligodendrocyte progenitor cell  differentiation  remyelination  U73122   Otilonium Bromide acts as a selective USP28 inhibitor and exhibits cytotoxic activity against multiple human cancer cell lines 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2023, 卷号: 215, 页码: 14 作者:  Xu, Zhuo   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/10/17 Otilonium Bromide  Deubiquitinase  USP28  Selective inhibitor   Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13 作者:  Hua, Chen;  Shena, Lijuan;  Zoua, Fengming;  Wua, Yun;  Wanga, Beilei   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/11/10 Acquired resistance mutations  CDK9 inhibitors  Transcription  Single nucleotide polymorphisms  BAY1251152   TGR5 agonist inhibits intestinal epithelial cell apoptosis via cAMP/PKA/c-FLIP/JNK signaling pathway and ameliorates dextran sulfate sodium-induced ulcerative colitis 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 卷号: 44, 期号: 8, 页码: 1649-1664 作者:  Yang, Wen-ji;  Han, Fang-hui;  Gu, Yi-pei;  Qu, Hui;  Liu, Jia   |  收藏  |  浏览/下载：2/0  |  提交时间：2024/03/27 TGR5 agonist  ulcerative colitis  intestinal epithelial cell  apoptosis  cAMP  PKA signaling pathway  c-FLIP   Discovery of a Novel Bifunctional Steroid Analog, YXG-158, as an Androgen Receptor Degrader and CYP17A1 Inhibitor for the Treatment of Enzalutamide-Resistant Prostate Cancer 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 14, 页码: 9972-9991 作者:  Wang, Ao;  Luo, Xianggang;  Meng, Xin;  Lu, Zhengyu;  Chen, Kaixian   |  收藏  |  浏览/下载：9/0  |  提交时间：2023/10/17