中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [138]
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期刊论文 [514]
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Discovery of a potent and selective covalent threonine tyrosine kinase (TTK) inhibitor
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 143, 页码: 16
作者:
Sun, Yaoliang
;
Chen, Zhiwen
;
Liu, Guobin
;
Chen, Xiaoai
;
Shi, Zihan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/03/25
Inhibitor
Cancer
Threonine tyrosine kinase (TTK)
Covalent
SIBP-03, a novel anti-HER3 antibody, exerts antitumor effects and synergizes with EGFR- and HER2-targeted drugs
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 10
作者:
Li, Wen-jing
;
Xie, Cheng-ying
;
Zhu, Xi
;
Tang, Jiao
;
Wang, Lei
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2024/02/19
SIBP-03
HER3
HER3-targeted therapy
neuregulin 1
EGFR
HER2
From bench to bedside: current development and emerging trend of KRAS-targeted therapy
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18
作者:
Chen, Yi
;
Liu, Qiu-pei
;
Xie, Hua
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2024/01/16
KRAS mutation
KRAS(G12C) inhibitor
Pan-KRAS inhibitor
SHP2 allosteric inhibitor
SOS1 inhibitor
combination therapy
Genomic and transcriptomic profiling indicates the prognosis significance of mutational signature for TMB-high subtype in Chinese patients with gastric cancer
期刊论文
OAI收割
JOURNAL OF ADVANCED RESEARCH, 2023, 卷号: 51, 页码: 121-134
作者:
Cheng, Yanan
;
Bu, Dechao
;
Zhang, Qiaoling
;
Sun, Rebecca
;
Lyle, Stephen
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2023/12/04
Gastric cancer
Comprehensive genomic profiling
TMB
Mutational signature
Tumor metabolism
Structural insights into the interaction of three Y- shaped ligands with PI3Kα
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 34, 页码: 9
作者:
Zhou, Qingtong
;
Liu, Xiao
;
Neri, Dario
;
Li, Wenxin
;
Favalli, Nicholas
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/12/08
phosphoinositide 3-kinase
drug target
ligand
binding pocket
chemical scaffold
Pharmacological targeting of Axin2 suppresses cell growth and metastasis in colorectal cancer
期刊论文
OAI收割
BRITISH JOURNAL OF PHARMACOLOGY, 2023, 页码: 21
作者:
Cheng, Li-Zhi
;
Huang, Dan-Ling
;
Tang, Zhang-Rui
;
Zhang, Jia-Hao
;
Xiong, Ting
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
colorectal cancer progression
GSK3 beta-Axin2 interaction
small-molecule inhibitor
Snail
beta-Trcp2
Preclinical Evaluation of 9MW2821, a Site-Specific Monomethyl Auristatin E-based Antibody-Drug Conjugate for Treatment of Nectin-4-expressing Cancers
期刊论文
OAI收割
MOLECULAR CANCER THERAPEUTICS, 2023, 卷号: 22, 期号: 8, 页码: 913-925
作者:
Zhou, Wei
;
Fang, Peng
;
Yu, Dongan
;
Ren, Hongyuan
;
You, Meng
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2023/10/17
ARID3a from the ARID family: structure, role in autoimmune diseases and drug discovery
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 12
作者:
Guo, Cheng-cen
;
Xu, H. Eric
;
Ma, Xiong
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/10/17
transcription factors
ARID
ARID3a
autoimmune diseases
systemic lupus erythematosus
primary biliary cholangitis
Structure-Activity Relationship Study of 1H-Pyrrole-3-carbonitrile Derivatives as STING Receptor Agonists
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2023, 页码: 9
作者:
Shen, Chang
;
Xu, Peijia
;
Zhang, Changfa
;
Su, Zhaoming
;
Shan, Bin
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2023/10/17
cGAS-STING signaling pathway
STING agonists
antitumor immunity
anti-infection immunity
Spatial association of surface water quality and human cancer in China
期刊论文
OAI收割
NPJ CLEAN WATER, 2023, 卷号: 6, 期号: 1, 页码: 9
作者:
Wang, Zixing
;
Gu, Wentao
;
Guo, Xiaobo
;
Xue, Fang
;
Zhao, Jing
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2023/10/09