机构

• 上海药物研究所 [34]

采集方式

• OAI收割 [34]

内容类型

• 期刊论文 [34]

发表日期

• 2024 [1]
• 2023 [2]
• 2022 [2]
• 2021 [5]
• 2020 [3]
• 2018 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共34条，第1-10条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Novel imidazo[1,2,4] triazole derivatives: Synthesis, fluorescence, bioactivity for SHP1 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 15 作者:  Yan, Xue;  Zhang, Chun;  Gao, Li-Xin;  Liu, Min -Min;  Yang, Yu-Ting   |  收藏  |  浏览/下载：9/0  |  提交时间：2024/02/27 Imidazo[124] triazole derivatives  Fluorescence property  SHP1  Bioactivity  Cellular imaging   From bench to bedside: current development and emerging trend of KRAS-targeted therapy 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18 作者:  Chen, Yi;  Liu, Qiu-pei;  Xie, Hua;  Ding, Jian   |  收藏  |  浏览/下载：28/0  |  提交时间：2024/01/16 KRAS mutation  KRAS(G12C) inhibitor  Pan-KRAS inhibitor  SHP2 allosteric inhibitor  SOS1 inhibitor  combination therapy   Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors 期刊论文  OAI收割 CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 8, 页码: 6 作者:  Xu, Lei;  Xuyan, Xuyang;  Minmi, Minmin;  Wang, Zhiji;  Shee, Chao   |  收藏  |  浏览/下载：27/0  |  提交时间：2023/10/17 Activator  PTPs  Inhibitor  Thieno[2  b ]quinoline derivatives  Diffuse large B-cell lymphoma   SH2 Domain-Containing Phosphatase 2 Inhibition Attenuates Osteoarthritis by Maintaining Homeostasis of Cartilage Metabolism via the Docking Protein 1/Uridine Phosphorylase 1/Uridine Cascade 期刊论文  OAI收割 ARTHRITIS & RHEUMATOLOGY, 2022, 页码: 12 作者:  Liu, Qianqian;  Zhai, Linhui;  Han, Mingrui;  Shi, Dongquan;  Sun, Ziying   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/06/15 Inhibiting Hvl channel in peripheral sensory neurons attenuates chronic inflammatory pain and opioid side effects 期刊论文  OAI收割 CELL RESEARCH, 2022, 卷号: 32, 期号: 5, 页码: 461 作者:  Zhang Qiansen;  Ren Yimin;  Mo Yiqing;  Guo Peipei;  Liao Ping   |  收藏  |  浏览/下载：10/0  |  提交时间：2023/05/22 Theoretical study and application of 2-phenyl-1,3,4-thiadiazole derivatives with optical and inhibitory activity against SHP1 期刊论文  OAI收割 PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2021, 页码: 14 作者:  Zhang, Chun;  Sun, Yi-Tao;  Gao, Li-Xin;  Feng, Bo;  Yan, Xue   |  收藏  |  浏览/下载：47/0  |  提交时间：2022/01/18 Synthesis and biological evaluation of 2,5-diaryl-1,3,4-oxadiazole derivatives as novel Src homology 2 domain-containing protein tyrosine phosphatase 2 (SHP2) inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 13 作者:  Meng, Xiang-Dong;  Gao, Li-Xin;  Wang, Zhi-Jia   |  收藏  |  浏览/下载：61/0  |  提交时间：2021/12/01 2,5-diphenyl-1,3,4-oxadiazole derivatives  SHP2  Inhibitors  Structure-activity relationships (SAR)   A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies 期刊论文  OAI收割 MOLECULAR CELL, 2021, 卷号: 81, 期号: 19, 页码: 4076-+ 作者:  Liu, Zhiwei;  Liu, Yingluo;  Qian, Lili;  Jiang, Shangwen;  Gai, Xiameng   |  收藏  |  浏览/下载：60/0  |  提交时间：2021/12/01 Synthesis of 5-Phenyl-1,3,4-thiadiazole Derivatives and Their Biochemical Evaluation against Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 1 (SHP1) 期刊论文  OAI收割 CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2021, 卷号: 41, 期号: 8, 页码: 3097-3105 作者:  Yu Lijie;  Feng Bo;  Wang Zhijia;  Gao Lixin;  Zhang Chun   |  收藏  |  浏览/下载：94/0  |  提交时间：2021/11/04 5-phenyl-1,3,4-thiadiazole derivatives  Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP1)  inhibitors  structure-activity relationships   Allosteric Inhibitors of SHP2: An Updated Patent Review (2015-2020) 期刊论文  OAI收割 CURRENT MEDICINAL CHEMISTRY, 2021, 卷号: 28, 期号: 19, 页码: 3825-3842 作者:  Wu, Jingwei;  Zhang, Huan;  Zhao, Guilong;  Wang, Runling   |  收藏  |  浏览/下载：15/0  |  提交时间：2021/08/17 SHP2 inhibitor  PTPN11 gene  allosteric  cancer  combination therapy  clinical trial