机构

• 上海药物研究所 [11]
• 金属研究所 [2]
• 福建物质结构研究所 [1]
• 大连化学物理研究所 [1]
• 昆明植物研究所 [1]

采集方式

• OAI收割 [16]

内容类型

• 期刊论文 [16]

发表日期

• 2023 [2]
• 2022 [2]
• 2021 [1]
• 2020 [1]
• 2019 [2]
• 2017 [1]
• 更多

学科主题

筛选

浏览/检索结果: 共16条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序发表日期升序发表日期降序题名升序题名降序作者升序作者降序 Discovery, Structure-Activity Relationship and In Vitro Anticancer Activity of Small-Molecule Inhibitors of the Protein-Protein Interactions between AF9/ENL and AF4 or DOT1L 期刊论文  OAI收割 CANCERS, 2023, 卷号: 15, 期号: 21, 页码: 28 作者:  Li, Xin;  Wu, Xiaowei   |  收藏  |  浏览/下载：7/0  |  提交时间：2023/12/19 MLL-rearranged leukemia  super elongation complexes  small-molecule inhibitor  protein-protein interaction  cancer therapeutics   Discovery of a highly potent NPAS3 heterodimer inhibitor by covalently modifying ARNT 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2023, 卷号: 139, 页码: 10 作者:  Li, Peizhuo;  Tian, Yucheng;  Shang, Qinghong;  Tang, Cailing;  Hou, Zeng   |  收藏  |  浏览/下载：22/0  |  提交时间：2023/10/17 NPAS3  Covalent inhibitor  Protein -protein interaction  5-nitrothiazole warhead   A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243, 页码: 31 作者:  Lou, Jianfeng;  Lu, Yuhang;  Cheng, Jing;  Zhou, Feilong;  Yan, Ziqin   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/12/13 TEAD  YAP  Palmitoylation  Protein-protein interaction  Covalent inhibitor   Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 236, 页码: 114327 作者:  Feng, Xuexin;  Yan, Ziqin;  Zhou, Feilong;  Lou, Jianfeng;  Lyu, Xilin   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/03/21 BFL-1  Apoptosis  Covalent inhibitor  Cytochrome c  BCL-2  Protein-Protein interaction   Discovery of pseudolaric acid A as a new Hsp90 inhibitor uncovers its potential anticancer mechanism 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2021, 卷号: 112, 页码: 104963 作者:  Liu,Jiangxin;  Wu,Xing-De;  Li,Wenyan;  Yuan,Zaifeng;  Yang,Kun   |  收藏  |  浏览/下载：15/0  |  提交时间：2022/04/02 Pseudolaric acid A  Hsp90 inhibitor  Apoptosis  NMR  Structure-activity relationship  Photoaffinity-based probe  Protein-ligand interaction  MOLECULAR CHAPERONE  PROTEIN  TARGET  CANCER  KINASE  NMR  IDENTIFICATION  SELECTIVITY  BINDING  DESIGN   A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP-Protein Interactions in Kidney Cancer Cells 期刊论文  OAI收割 CHINESE JOURNAL OF CHEMISTRY, 2020, 页码: 274-280 作者:  Wang, Zhen;  Zhang, Hao;  Chen, Baoen;  Ouyang, Sisheng;  Zheng, Tong   |  收藏  |  浏览/下载：122/0  |  提交时间：2021/05/24 SPOP  Protein‐  protein interaction  Clear cell Renal Cell Carcinomas  Crystal structure  Peptide inhibitor   Tranylcypromine and 6-trifluoroethyl thienopyrimidine hybrid as LSD1 inhibitor 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 844-847 作者:  Wang, Xiaowen;  Su, Mingbo;  Li, You;  Liu, Tongchao;  Wang, Yujie   |  收藏  |  浏览/下载：13/0  |  提交时间：2020/07/01 LSD1 inhibitor  Tranylcypromine  Menin-MLL1 protei n-protein interaction inhibitor  MV4-11 antiproliferative activity  Structure activity relationship   Fragment-based drug discovery of triazole inhibitors to block PDE delta-RAS protein-protein interaction 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 163, 页码: 597-609 作者:  Chen, Danqi;  Chen, Yuehong;  Lian, Fulin;  Chen, Liu;  Li, Yanlian   |  收藏  |  浏览/下载：16/0  |  提交时间：2020/07/01 PDE delta-RAS  Fragment-based  Inhibitor  Protein-protein interaction   Inhibition of human catechol-O-methyltransferase-mediated dopamine O-methylation by daphnetin and its Phase II metabolites 期刊论文  OAI收割 XENOBIOTICA, 2017, 卷号: 47, 期号: 6, 页码: 498-504 作者:  Tu, Cai-Xia;  Liang, Si-Cheng;  Ge, Guang-Bo;  Xia, Yang-Liu;  Dong, Pei-Pei 收藏  |  浏览/下载：20/0  |  提交时间：2017/10/29 Daphnetin  COMT inhibitor  8-O-methyldaphnetin  ligand-protein interaction  Phase II metabolite  structural modification   Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 卷号: 291, 期号: 21, 页码: 11083-11093 作者:  Li, Qi;  Huang, Yue;  Liu, Xichun;  Gan, Jianhua;  Chen, Hao   |  收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08 bacteria  cancer therapy  chemical biology  DNA repair  DNA-protein interaction  enzyme inhibitor  enzyme structure