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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [58]
采集方式
OAI收割 [58]
内容类型
期刊论文 [58]
发表日期
2024 [2]
2023 [2]
2022 [6]
2019 [3]
2017 [4]
2015 [2]
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Biochemist... [1]
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内容类型:期刊论文
专题:上海药物研究所
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Discovery of novel SOS1 inhibitors using machine learning
期刊论文
OAI收割
RSC MEDICINAL CHEMISTRY, 2024, 卷号: 15, 期号: 4, 页码: 1392-1403
作者:
Duo, Lihui
;
Chen, Yi
;
Liu, Qiupei
;
Ma, Zhangyi
;
Farjudian, Amin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Development and Validation of an ADA-Tolerant Assay for Quantification of an Exatecan-Based ADC in Monkey Plasma
期刊论文
OAI收割
MOLECULES, 2024, 卷号: 29, 期号: 3, 页码: 14
作者:
Tao, Yimin
;
Lu, Wei
;
Gao, Jinli
;
Yang, Shuangshuang
;
Ruan, Chaoyi
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/03/13
antibody-drug conjugate (ADC)
bioanalysis
anti-drug antibody (ADA)
ligand binding assay (LBA)
ADA-tolerant assay
Exploring the mechanism of the PTP1B inhibitors by molecular dynamics and experimental study
期刊论文
OAI收割
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 2023, 卷号: 125, 页码: 12
作者:
Zhao, Tian-Tian
;
Hu, Hao-Jie
;
Gao, Li-Xin
;
Zhou, Yu-Bo
;
Zhu, Yun-Long
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
Protein tyrosine phosphatases inhibitors
PTP1B inhibitors
Mechanism study
Molecular dynamics
Design, Synthesis and Bioactivity of [3.3.3]Propellane-Based Voltage-Gated Calcium Channel alpha 2 delta Subunit Ligands
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2023, 卷号: 43, 期号: 6, 页码: 2226-2238
作者:
He Jinyan
;
Tian Fuyun
;
Wu Qingqing
;
Zheng Yueming
;
Chen Yuting
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2023/10/17
propellane
voltage-gated calcium channel
alpha 2 delta subunit
synthesis
bioactivity
structure-activity relationship
Current Analytical Strategies for Antibody-Drug Conjugates in Biomatrices
期刊论文
OAI收割
MOLECULES, 2022, 卷号: 27, 期号: 19, 页码: 17
作者:
Qin, Qiuping
;
Gong, Likun
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/11/11
ADC
antibody
payload
LBA
LC-MS
bioanalysis
immunogenicity
interference
Antinociceptive activities and mechanism of action of Cepharanthine
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2022, 卷号: 614, 页码: 219-224
作者:
Wei, Xiang-Yan
;
Long, Jian-Dong
;
Chai, Jing-Rui
;
Chen, Jing
;
Gao, Jian-Ping
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/08/16
Cepharanthine
Antinociception
mu opioid receptors
Constipation
Development and validation of a ligand-binding assay for quantification of the F(ab')(2) antivenom of Daboia russelii siamensis in human serum and its application to a phase I clinical study
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022, 卷号: 212, 页码: 8
作者:
Gui, Yuzhou
;
Yu, Chengyin
;
Zhou, Jiaye
;
Xin, Liang
;
Chen, Ze
  |  
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2022/06/15
F(ab')(2) antivenom
Daboia russelii siamensis
Ligand-binding assay
Method validation
Clinical trial
Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 13
作者:
Duan, Jia
;
Shen, Dan-Dan
;
Zhao, Tingting
;
Guo, Shimeng
;
He, Xinheng
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2022/08/16
In silico screening-based discovery of novel covalent inhibitors of the SARS-CoV-2 3CL protease
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 231, 页码: 8
作者:
Xiong, Muya
;
Nie, Tianqing
;
Shao, Qiang
;
Li, Minjun
;
Su, Haixia
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2022/06/15
SARS-CoV-2 3C-Like protease
Covalent inhibitor
Virtual screening
Crystal structure
Efficient discovery of potential inhibitors for SARS-CoV-2 3C-like protease from herbal extracts using a native MS-based affinity-selection method
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2022, 卷号: 209, 页码: 8
作者:
Zhu, Dafu
;
Su, Haixia
;
Ke, Changqiang
;
Tang, Chunping
;
Witt, Matthias
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2022/06/15
SARS-CoV-2
3CL protease
Native MS
Traditional Chinese medicine
Natural product