中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [38]
合肥物质科学研究院 [2]
心理研究所 [1]
武汉植物园 [1]
植物研究所 [1]
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OAI收割 [43]
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期刊论文 [41]
会议论文 [2]
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2024 [3]
2023 [4]
2022 [6]
2021 [5]
2020 [2]
2019 [4]
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Oncogenic KRAS Induces Arginine Auxotrophy and Confers a Therapeutic Vulnerability to SLC7A1 Inhibition in Non-Small Cell Lung Cancer
期刊论文
OAI收割
CANCER RESEARCH, 2024, 卷号: 84, 期号: 12, 页码: 1963-1977
作者:
Gai, Xiameng
;
Liu, Yingluo
;
Lan, Xiaojing
;
Chen, Luoyi
;
Yuan, Tao
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/08/20
Structure-based discovery of a new series of nucleoside-derived ring-opening PRMT5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 267, 页码: 19
作者:
Chen, Yuting
;
Wang, Zekun
;
Zhang, Junjie
;
Shi, Qiongyu
;
Yang, Hong
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/05/07
PRMT5
Nucleoside derivatives
Methyltransferases
Structure -activity relationship
The Design of the Multimodal-Based Educational Support Platform for Music and Reading in Elementary Schools
会议论文
OAI收割
2024 IEEE 4th International Conference on Electronic Communications, Internet of Things and Big Data, ICEIB, 不详, 2024
作者:
Mengzhe,Lin
;
Meiyu,Hong
;
Ye,Liu
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/09/02
Structure-based drug discovery of novel fused- pyrazolone carboxamide derivatives as potent and selective AXL inhibitors
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4918-4933
作者:
Fang, Feifei
;
Dai, Yang
;
Wang, Hao
;
Ji, Yinchun
;
Liang, Xuewu
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2024/01/26
derivatives
Antitumor drug development
Potential AXL inhibitor
Antitumor activity
Structure-based drug design
Fused-pyrazolone carboxamide
Tetrandrine synergizes with MAPK inhibitors in treating KRAS-mutant pancreatic ductal adenocarcinoma via collaboratively modulating the TRAIL-death receptor axis
期刊论文
OAI收割
PHARMACOLOGICAL RESEARCH, 2023, 卷号: 197, 页码: 12
作者:
Tang, Shuai
;
Duan, Yichen
;
Yuan, Tao
;
Hu, Yutinh
;
Yuan, Liang
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2023/12/11
KRAS
Pancreatic ductal adenocarcinoma
MAPK pathway
Tetrandrine
TRAIL
Death receptors
Structural Optimization of Fibroblast Growth Factor Receptor Inhibitors for Treating Solid Tumors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 5, 页码: 3226-3249
作者:
Li, Chunpu
;
Dai, Yang
;
Kong, Xiangtai
;
Wang, Bao
;
Peng, Xia
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/03/27
Structural Modification and Pharmacological Evaluation of Substituted Quinoline-5,8-diones as Potent NSD2 Inhibitors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2023, 页码: 18
作者:
Tang, Hairong
;
Yu, Aisong
;
Xing, Li
;
Chen, Xiaoyu
;
Ding, Huaqian
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2023/04/10
Chinese expert consensus on the multidisciplinary management of pneumonitis associated with immune checkpoint inhibitor
期刊论文
OAI收割
THORACIC CANCER, 2022
作者:
Wang, Wenxian
;
Wang, Qian
;
Xu, Chunwei
;
Li, Ziming
;
Song, Zhengbo
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2022/12/23
checkpoint inhibitor pneumonitis
Chinese experts consensus
immune checkpoint inhibitor-related adverse effects
Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China
期刊论文
OAI收割
THORACIC CANCER, 2022
作者:
Xu, Chunwei
;
Si, Lu
;
Wang, Wenxian
;
Li, Ziming
;
Song, Zhengbo
  |  
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2022/12/22
fusion
precision medicine
solid tumor
targeted therapy
tyrosine receptor kinase
Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 239, 页码: 18
作者:
Sun, Yaoliang
;
Zhang, Ying
;
Chen, Xiaoai
;
Yu, Aisong
;
Du, Wenhao
  |  
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2022/08/30
NSD3
PROTAC
Degrader
Methyltransferase