中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
地理科学与资源研究所 [5]
上海药物研究所 [5]
深圳先进技术研究院 [3]
半导体研究所 [3]
广州生物医药与健康研... [2]
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期刊论文 [22]
会议论文 [1]
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2024 [1]
2023 [2]
2022 [3]
2021 [3]
2020 [1]
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Structure-based design of potent FABP4 inhibitors with high selectivity against FABP3
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 264, 页码: 10
作者:
Chen, Guofeng
;
Xie, Hang
;
Liu, Jiayuan
;
Shao, Qiang
;
Li, Minjun
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2024/01/26
Methyl substitution
Selectivity
FABP4 inhibitor
Anti-inflammation
Metabolic stability
Drug repurposing and structure-based discovery of new PDE4 and PDE5 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 14
作者:
Liu, Jiayuan
;
Zhang, Xianglei
;
Chen, Guofeng
;
Shao, Qiang
;
Zou, Yi
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2024/01/16
Phosphodiesterase-4 (PDE4)
PDE5
Inhibitor
Drug repurposing
Crystal structure
Structure -guided optimization
Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 卷号: 24, 期号: 10, 页码: 15
作者:
Wang, Qian
;
Chen, Guofeng
;
He, Jian
;
Li, Jiameng
;
Xiong, Muya
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2023/10/17
SARS-CoV-2
papain-like protease
covalent inhibitor
co-crystal structure
in vitro assay
Identification of Cysteine 270 as a Novel Site for Allosteric Modulators of SARS-CoV-2 Papain-Like Protease
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 页码: 10
作者:
Hu, Hangchen
;
Wang, Qian
;
Su, Haixia
;
Shao, Qiang
;
Zhao, Wenfeng
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2023/04/10
Allosteric Modulator
Cysteine 270
Drug Design
Papain-Like Protease
SARS-CoV-2
Ecological carrying capacity and sustainability assessment for coastal zones: A novel framework based on spatial scene and three-dimensional ecological footprint model
期刊论文
OAI收割
ECOLOGICAL MODELLING, 2022, 卷号: 466, 页码: 16
作者:
Tang, Yuzhi
;
Wang, Mengdi
;
Liu, Qian
;
Hu, Zhongwen
;
Zhang, Jie
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/09/21
Coastal zone
Ecological carrying capacity
Spatial scene
Three-dimensional ecological footprint
Guangdong-Hong Kong-Macao Greater Bay
Area
Ecological carrying capacity and sustainability assessment for coastal zones: A novel framework based on spatial scene and three-dimensional ecological footprint model
期刊论文
OAI收割
ECOLOGICAL MODELLING, 2022, 卷号: 466, 页码: 16
作者:
Tang, Yuzhi
;
Wang, Mengdi
;
Liu, Qian
;
Hu, Zhongwen
;
Zhang, Jie
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2022/09/21
Coastal zone
Ecological carrying capacity
Spatial scene
Three-dimensional ecological footprint
Guangdong-Hong Kong-Macao Greater Bay
Area
Digital mapping of zinc in urban topsoil using multisource geospatial data and random forest
期刊论文
OAI收割
SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 卷号: 792, 页码: 8
作者:
Shi, Tiezhu
;
Hu, Xianjun
;
Guo, Long
;
Su, Fenzheng
;
Tu, Wei
  |  
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/11/05
Digital soil mapping
Remote sensing data
Social sensing data
Geodetector
Urban functional type
Observations of Forbush Decreases of Cosmic-Ray Electrons and Positrons with the Dark Matter Particle Explorer
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2021, 卷号: 920, 期号: 2, 页码: 10
作者:
Alemanno, Francesca
;
An, Qi
;
Azzarello, Philipp
;
Barbato, Felicia Carla Tiziana
;
Bernardini, Paolo
  |  
收藏
  |  
浏览/下载:119/0
  |  
提交时间:2021/12/08
Solar coronal mass ejections
Forbush effect
Cosmic rays
Mapping lead concentrations in urban topsoil using proximal and remote sensing data and hybrid statistical approaches
期刊论文
OAI收割
ENVIRONMENTAL POLLUTION, 2021, 卷号: 272, 页码: 10
作者:
Shi, Tiezhu
;
Yang, Chao
;
Liu, Huizeng
;
Wu, Chao
;
Wang, Zhihua
  |  
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/04/25
Jenny's state factor model
Visible and near-infrared reflectance spectroscopy
Landsat image
Geographically weighted regression
Regression kriging
Exploration of Fragment Binding Poses Leading to Efficient Discovery of Highly Potent and Orally Effective Inhibitors of FABP4 for Anti-inflammation
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4090-4106
作者:
Su, Haixia
;
Zou, Yi
;
Chen, Guofeng
;
Dou, Huixia
;
Xie, Hang
  |  
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2020/07/01