机构

• 上海药物研究所 [6]
• 化学研究所 [2]
• 大连化学物理研究所 [1]

采集方式

• OAI收割 [9]

内容类型

• 期刊论文 [9]

发表日期

• 2024 [2]
• 2023 [1]
• 2019 [1]
• 2017 [1]
• 2014 [1]
• 2010 [1]
• 更多

学科主题

• 物理化学 [1]

筛选

浏览/检索结果: 共9条，第1-9条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Design, synthesis and evaluation of thieno[3,2-d]pyrimidine derivatives as novel potent CDK7 inhibitors 期刊论文  OAI收割 BIOORGANIC CHEMISTRY, 2024, 卷号: 148, 页码: 15 作者:  Zhang, Hongjin;  Lin, Guohao;  Jia, Suyun;  Wu, Jianbo;  Zhang, Ying   |  收藏  |  浏览/下载：16/0  |  提交时间：2024/09/26 Cyclin-dependent kinase 7  Small molecular inhibitor  Triple negative breast cancer  Thieno[3,2-d]pyrimidine derivative   Discovery and optimization of thieno[3,2-d]pyrimidine derivatives as highly selective inhibitors of cyclin-dependent kinase 7 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 263, 页码: 21 作者:  Zhang, Hongjin;  Lin, Guohao;  Jia, Suyun;  Zhang, Ying;  Wu, Jianbo   |  收藏  |  浏览/下载：15/0  |  提交时间：2024/01/26 Thieno[3  d ]pyrimidine derivative  Cyclin-dependent kinase 7  Small molecule inhibitor  Kinome selectivity  Triple negative breast cancer   Application of deep generative model for design of Pyrrolo[2,3-d] pyrimidine derivatives as new selective TANK binding kinase 1 (TBK1) inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 247, 页码: 115034 作者:  Song, Shukai;  Tang, Haotian;  Ran, Ting;  Fang, Feng;  Tong, Linjiang   |  收藏  |  浏览/下载：12/0  |  提交时间：2024/03/27 SyntaLinker  Generative modelling  TBK1 inhibitor  pyrrolo[2  3-d]pyrimidine  Structure-activity relationship   Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors 期刊论文  OAI收割 CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022 作者:  Yang, Xiuyan;  Deng, Meng;  Zhang, Xi;  Wang, Yi;  Song, Kun   |  收藏  |  浏览/下载：46/0  |  提交时间：2020/07/01 PI3K alpha inhibitors  proliferation inhibition  thieno[3  2-d]pyrimidine derivatives   Synthesis and structure-activity relationship study of pyrazolo[3,4-d]pyrimidines as tyrosine kinase RET inhibitors 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 11, 页码: 2544-2548 作者:  Wang, Chengyan;  Liu, Hongchun;  Song, Zilan;  Ji, Yinchun;  Xing, Li   |  收藏  |  浏览/下载：42/0  |  提交时间：2019/01/08 Tyrosine kinase RET  Pyrazolo[3,4-d]pyrimidine  Anticancer  Cell proliferation  Structure-activity relationship   Insight into the binding mode and the structural features of the pyrimidine derivatives as human A(2A) adenosine receptor antagonists 期刊论文  OAI收割 biosystems, 2014, 卷号: 115, 期号: 1, 页码: 13-22 作者:  Zhang, Lihui;  Liu, Tianjun;  Wang, Xia;  Wang, Jinan;  Li, Guohui 收藏  |  浏览/下载：30/0  |  提交时间：2015/11/16 Pyrimidine derivatives  Human A(2A) adenosine receptor  Molecular docking  Molecular dynamics  Thermodynamic analysis  3D-QSAR   One-pot Synthesis of 2,4-Diamino-substituted Thieno[3,2-d]pyrimidines 期刊论文  OAI收割 CHINESE JOURNAL OF CHEMISTRY, 2010, 卷号: 28, 期号: 8, 页码: 1437-1440 作者:  Li Xiaoying;  Zhang Yangming;  Tang Jie;  Yang Fan;  Nan Fajun   |  收藏  |  浏览/下载：14/0  |  提交时间：2019/01/08 privileged structure  2,4-dichlorothieno[3,2-d]pyrimidine  one-pot   Synthesis of trifluoromethyl-promoted functional pyrazolo [1,5-a]pyrimidine and pyrazolo [5,1-d] [1,2,3,5]tetrazine-4(3H)-ones 期刊论文  OAI收割 JOURNAL OF FLUORINE CHEMISTRY, 2006, 卷号: 127, 期号: 3, 页码: 409-416 作者:  Wu, YC;  Chen, YJ;  Li, HJ;  Zou, XM;  Hu, FZ   |  收藏  |  浏览/下载：15/0  |  提交时间：2019/04/09 Fluorine  Pyrazole  Inhibitor  Pyrazolo[1  Pyrazolo[5  5-a]Pyrimidine  1-d][1  2  3  5]Tetrazine-4(3h)-one   Synthesis of novel dipyrazolopyrimidine fused heterotricyclic compounds 期刊论文  OAI收割 CHINESE JOURNAL OF CHEMISTRY, 2005, 卷号: 23, 期号: 2, 页码: 182-184 作者:  Liu, Y;  Zhang, XH;  Jin, GY   |  收藏  |  浏览/下载：14/0  |  提交时间：2019/04/09 1h-pyrazole-4-carboxamide  Synthesis  1h-dipyrazolo[1  1h-dipyrazolo[1  5-a : 3 '  5-a : 4 '  4 '-d]Pydmidine-4(9h)-one  3 '-e]Pyrimidine-4(5h)-one