机构

• 上海药物研究所 [23]
• 生物物理研究所 [1]
• 大连化学物理研究所 [1]
• 合肥物质科学研究院 [1]

采集方式

• OAI收割 [26]

内容类型

• 期刊论文 [26]

发表日期

• 2025 [1]
• 2024 [1]
• 2023 [1]
• 2022 [4]
• 2021 [1]
• 2020 [4]
• 更多

学科主题

• Biochemica... [1]

筛选

浏览/检索结果: 共26条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序作者升序作者降序 Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology 期刊论文  OAI收割 ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2025, 卷号: 65, 页码: 191-213 作者:  Zhou, Qingtong;  Li, Guanyi;  Hang, Kaini;  Li, Jie;  Yang, Dehua   |  收藏  |  浏览/下载：8/0  |  提交时间：2025/04/01 overweight  glucagon-like peptide-1 receptor  unimolecular  polypharmacology  tirzepatide  retatrutide  metabolic diseases   Absence of PNET formation and normal longevity in a mouse model of Mahvash disease 期刊论文  OAI收割 HELIYON, 2024, 卷号: 10, 期号: 15, 页码: 13 作者:  Xu, Yingna;  Liu, Qiaofeng;  Chen, Chuan-Wei;  Wang, Qiuying;  Du, Tianyuan   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/09/26 Glucagon  Glucagon receptor  Amino acid  Metabolism  Mahvash disease   Structural analysis of the dual agonism at GLP-1R and GCGR 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2023, 卷号: 120, 期号: 33, 页码: 12 作者:  Li, Yang;  Zhou, Qingtong;  Dai, Antao;  Zhao, Fenghui;  Chang, Rulue   |  收藏  |  浏览/下载：20/0  |  提交时间：2024/05/07 glucagon-like peptide-1 receptor  glucagon receptor  cryo-electron microscopy  dual agonism   Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13 作者:  Darbalaei, Sanaz;  Chang, Ru-lue;  Zhou, Qing-tong;  Chen, Yan;  Dai, An-tao   |  收藏  |  浏览/下载：33/0  |  提交时间：2022/09/30 glucagon-like peptide-1 receptor  glucagon receptor  dual and triple agonist  cAMP  pERK1/2  unimolecular polypharmacology   Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists 期刊论文  OAI收割 PHARMACEUTICALS, 2022, 卷号: 15 作者:  Sun, Lei;  Zheng, Zhi-Ming;  Shao, Chang-Sheng;  Zhang, Zhi-Yong;  Li, Ming-Wei   |  收藏  |  浏览/下载：27/0  |  提交时间：2022/12/22 glucagon-like peptide-1  GLP-1 receptor agonist  functional protein design  molecular dynamics simulation  long-acting antihyperglycemic   Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24 期刊论文  OAI收割 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2022, 卷号: 119, 期号: 20, 页码: 10 作者:  Cong, Zhaotong;  Zhou, Qingtong;  Li, Yang;  Chen, Li-Nan;  Zhang, Zi-Chen   |  收藏  |  浏览/下载：44/0  |  提交时间：2022/09/30 glucagon-like peptide-1 receptor  type 2 diabetes mellitus  cryoelectron microscopy  peptidomimetic agonism   Modulating effects of RAMPs on signaling profiles of the glucagon receptor family 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2022, 卷号: 12, 期号: 2, 页码: 637-650 作者:  Shao, Lijun;  Chen, Yan;  Zhang, Shikai;  Zhang, Zhihui;  Cao, Yongbing   |  收藏  |  浏览/下载：39/0  |  提交时间：2022/06/15 G protein-coupled receptor  Glucagon receptor family  Receptor activity-modulating protein  Signaling  Allosteric modulation  GPCR-RAMP interaction  Receptor pharmacology  Ligand selectivity   Signaling profiles in HEK 293T cells co-expressing GLP-1 and GIP receptors 期刊论文  OAI收割 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 8 作者:  Wang, Yu-zhe;  Yang, De-hua;  Wang, Ming-wei   |  收藏  |  浏览/下载：33/0  |  提交时间：2021/11/04 glucagon-like peptide-1 receptor  glucose-dependent insulinotropic peptide receptor  peptide 19  LY3298176  heteromerization  type 2 diabetes   Evaluation of biased agonism mediated by dual agonists of the GLP-1 and glucagon receptors 期刊论文  OAI收割 BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 180, 页码: 16 作者:  Darbalaei, Sanaz;  Yuliantie, Elita;  Dai, Antao;  Chang, Rulue;  Zhao, Peishen   |  收藏  |  浏览/下载：35/0  |  提交时间：2020/12/21 G protein-coupled receptor  Glucagon-like peptide-1 receptor  Glucagon receptor  Biased agonism  Unimolecular dual agonist   Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide 期刊论文  OAI收割 JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 卷号: 295, 期号: 28, 页码: 9313-9325 作者:  Chang, Rulue;  Zhang, Xin;  Qiao, Anna;  Dai, Antao;  Belousoff, Matthew J.   |  收藏  |  浏览/下载：55/0  |  提交时间：2020/12/24 glucagon receptor  glucagon-like peptide-1 receptor  dual agonist  cryo-electron microscopy  single particle analysis  structure-function  structural biology  peptide 15 (P15)  metabolic disorder  G protein?coupled receptor (GPCR)  glucagon  GLP-1 receptor