中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [5]
大连化学物理研究所 [2]
化学研究所 [1]
采集方式
OAI收割 [8]
内容类型
期刊论文 [8]
发表日期
2025 [1]
2024 [2]
2022 [1]
2018 [1]
2016 [1]
2014 [1]
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学科主题
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Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology
期刊论文
OAI收割
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2025, 卷号: 65, 页码: 191-213
作者:
Zhou, Qingtong
;
Li, Guanyi
;
Hang, Kaini
;
Li, Jie
;
Yang, Dehua
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/04/01
overweight
glucagon-like peptide-1 receptor
unimolecular
polypharmacology
tirzepatide
retatrutide
metabolic diseases
Pharmacologically significant constituents collectively responsible for anti-sepsis action of XueBiJing, a Chinese herb-based intravenous formulation
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 16
作者:
Cheng, Chen
;
Ren, Chao
;
Li, Mu-zi
;
Liu, Yi-hui
;
Yao, Ren-qi
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2024/02/27
Traditional Chinese medicine
XueBiJing
sepsis
mortality
pharmacokinetic compatibility
polypharmacology
KinomeMETA: meta-learning enhanced kinome-wide polypharmacology profiling
期刊论文
OAI收割
BRIEFINGS IN BIOINFORMATICS, 2024, 卷号: 25, 期号: 1, 页码: 15
作者:
Ren, Qun
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2024/05/07
kinome profiling
kinase inhibitors
polypharmacology
deep learning
meta-learning
Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2022, 页码: 13
作者:
Darbalaei, Sanaz
;
Chang, Ru-lue
;
Zhou, Qing-tong
;
Chen, Yan
;
Dai, An-tao
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2022/09/30
glucagon-like peptide-1 receptor
glucagon receptor
dual and triple agonist
cAMP
pERK1/2
unimolecular polypharmacology
Computational chemical biology and drug design: Facilitating protein structure, function, and modulation studies
期刊论文
OAI收割
MEDICINAL RESEARCH REVIEWS, 2018, 卷号: 38, 期号: 3, 页码: 914-950
作者:
Zheng, Mingyue
;
Zhao, Jihui
;
Cui, Chen
;
Fu, Zunyun
;
Li, Xutong
  |  
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
ADMET
chemical biology
drug design
in silico
lead optimization
molecular dynamics
polypharmacology
virtual screening
Label-Free Cell Phenotypic Assays for Assessing Drug Polypharmacology
期刊论文
OAI收割
CURRENT PHARMACEUTICAL DESIGN, 2016, 卷号: 22, 期号: 21, 页码: 3190-3200
作者:
Wang, Jixia
;
Zhang, Xiuli
;
Fang, Ye
;
Liang, Xinmiao
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/06/20
Label-free Cell Phenotypic Assay
Mechanism Of Action
Multi-target Screen
Polypharmacology
Resonant Waveguide Grating Biosensor
Electric Biosensor
A novel systems pharmacology model for herbal medicine injection: a case using reduning injection
期刊论文
OAI收割
bmc complementary and alternative medicine, 2014, 卷号: 14
作者:
Yang, Haixing
;
Zhang, Wenjuan
;
Huang, Chao
;
Zhou, Wei
;
Yao, Yao
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2015/11/17
Systems pharmacology
Reduning injection
Polypharmacology
Mechanism of action
Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus
期刊论文
OAI收割
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2011, 卷号: 35, 期号: 5, 页码: 293-297
作者:
Gu, Jiangyong
;
Zhang, Hu
;
Chen, Lirong
;
Xu, Shun
;
Yuan, Gu
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/04/09
Type Ii Diabetes
Network Analysis
Virtual Screening
Traditional Chinese Medicine
Drug-target Network
Polypharmacology