中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [15]
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Design, Synthesis, and Structure-Activity Relationship of Novel Potent and Highly Selective Cysteinyl Leukotriene Receptor 1 (CysLT1R) Antagonists
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 44, 期号: 1, 页码: 259-276
作者:
Wang Jingyi
;
Liu Jinyu
;
Chen Dongsheng
;
Chen Huayan
;
Xie Xin
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/05/07
cysteinyl leukotriene
cysteinyl leukotriene receptor 1 (CysLT1R)
selective antagonists
11-Ethoxyviburtinal improves chronic restraint stress-induced anxiety-like behaviors in gender-specific mice via PI3K/Akt and E-2/ER beta signaling pathways
期刊论文
OAI收割
PHYTOTHERAPY RESEARCH, 2023, 页码: 17
作者:
Lyu, Yan
;
Wei, Xiaojia
;
Yang, Xue
;
Li, Jiayuan
;
Wan, Guohui
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2023/10/09
11-ethoxyviburtinal
antagonists
anxiety disorder
estrogen receptor beta
PI3K-Akt signaling pathway
the male and female mice
Simulating androgen receptor selection in designer yeast
期刊论文
OAI收割
SYNTHETIC AND SYSTEMS BIOTECHNOLOGY, 2022, 卷号: 7
作者:
Zhang, Haoran
;
Zhang, Lu
;
Xu, Yipeng
;
Chen, Shaoyong
;
Ma, Zhenyi
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2022/12/23
Androgen receptor mutations
Androgen receptor antagonists
Prostate cancer
Saccharomyces cerevisiae
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 31, 页码: 13
作者:
Wang, Ao
;
Wang, Yawan
;
Meng, Xin
;
Yang, Yushe
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
Androgen receptor
Novel thiohydantoin derivatives
Androgen receptor antagonists
Prostate cancer
Identification of SARS-CoV-2 entry inhibitors among already approved drugs
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 7
作者:
Yang, Li
;
Pei, Rong-juan
;
Li, Heng
  |  
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2020/12/24
COVID-19
SARS-CoV-2
virus entry inhibitors
high throughput screening assay
approved drug library
histamine receptor antagonists
clemastine
The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 149, 页码: 148-169
作者:
Peng, Dian
;
Cao, Bin
;
Zhou, Ying-Jun
;
Long, Ya-Qiu
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2019/01/08
CXC chemokine receptor 4
Small molecule antagonists
Structure-based optimization
HIV-1 entry
Tumor metastasis
Inflammation
Ischemia-reperfusion
Autoimmune
High yield and efficient expression and purification of the human 5-HT_(3A) receptor
期刊论文
OAI收割
Acta Pharmacologica Sinica, 2015, 卷号: 36, 期号: 8, 页码: 1024
作者:
Wu Zhongshan
;
Cui Zhicheng
;
Cheng Hao
;
Fan Chen
;
Melcher Karsten
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
GATED ION-CHANNEL
CYS-LOOP RECEPTOR
X-RAY-STRUCTURE
STRUCTURAL BASIS
SYSTEM
PHARMACOLOGY
RECOGNITION
CONDUCTANCE
ANTAGONISTS
PREVENTION
human 5-HT3A receptor
BacMam
expression and purification
negative stain electron microscopy
receptor structure
Nanoscale Organization of Human GnRH-R on Human Bladder Cancer Cells
期刊论文
OAI收割
analytical chemistry, 2014, 卷号: 86, 期号: 5, 页码: 2458-2464
Zhang, Jing
;
Chtcheglova, Lilia A.
;
Zhu, Rong
;
Hinterdorfer,Peter
;
Zhang,Bailin
;
Tang,Jilin
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2015/06/10
GONADOTROPIN-RELEASING-HORMONE
ATOMIC-FORCE MICROSCOPY
SIMULTANEOUS TOPOGRAPHY
RECOGNITION EVENTS
ENDOTHELIAL-CELLS
LOCALIZATION
RECEPTOR
ANTAGONISTS
DELIVERY
TISSUES
On-line focusing of 5-hydroxy-tryptamine type 3 receptor antagonists via the combination of field-enhanced sample injection and dynamic pH junction in capillary electrophoresis with amperometric detection
期刊论文
OAI收割
journal of chromatography a, 2014, 卷号: 331, 期号: 3, 页码: 117-122
Li, Libo
;
Xu, Lei
;
Huang, Jianshe
;
You,Tianyan
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2015/10/19
Capillary electrophoresis
Amperometric detection
Field-enhanced sample injection
Dynamic pH junction
5-HT3 receptor antagonists
[5C+1N] Annulation of 2,4-pentadienenitriles with hydroxylamine: a synthetic route to multi-substituted 2-aminopyridines
期刊论文
OAI收割
organic & biomolecular chemistry, 2013, 卷号: 11, 期号: 6, 页码: 1001-1006
Xin XQ
;
Huang P
;
Xiang DX
;
Zhang R
;
Zhao FY
;
Zhang N
;
Dong DW
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2014/04/18
SUBSTITUTED PYRIDINE-DERIVATIVES
ONE-POT SYNTHESIS
RECEPTOR ANTAGONISTS
EFFICIENT METHOD
DIRECT ACCESS
MILD
HETEROCYCLES
INHIBITORS
DISCOVERY
CYCLOADDITION